| Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A2. | Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).
Koganesawa M, Yamaguchi M, Samuchiwal SK, Balestrieri B., Free PMC Article | 09/11/2021 |
| Lysosome-mediated autophagy pathway contributes to gVPLA2 clearance from lung endothelial cells. | Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.
Meliton LN, Zhu X, Brown M, Epshtein Y, Kawasaki T, Letsiou E, Dudek SM., Free PMC Article | 07/25/2020 |
| This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2. | Hydrolysis of Phosphatidylcholine-Isoprostanes (PtdCho-IP) by Peripheral Human Group IIA, V and X Secretory Phospholipases A(2) (sPLA(2)).
Kuksis A, Pruzanski W. | 03/10/2018 |
| Low GV-PLA2 expression is associated with cancer. | Epigenetic control of group V phospholipase A2 expression in human malignant cells.
Menschikowski M, Hagelgans A, Nacke B, Jandeck C, Mareninova OA, Asatryan L, Siegert G. | 02/18/2017 |
| Data show that phospholipase A2 group IIA, V and X have different target/function related activity. | Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X.
Pruzanski W, Kopilov J, Kuksis A. | 12/17/2016 |
| The clinical findings in this family suggest a diagnosis of benign familial fleck retina with excellent prognosis, in which the PLA2G5 gene may play a role. | Phospholipase A2 group v in benign familial fleck retina in a set of triplets.
Bin NJ, Heng HM, Poh R, Noor SM, Subrayan V. | 11/7/2015 |
| sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation. | Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo.
Tamayo I, Velasco SE, Puy C, Esmon CT, Dichiara MG, Montes R, Hermida J. | 10/17/2015 |
| results demonstrate that EPCR is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2 | Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.
Xue M, Shen K, McKelvey K, Li J, Chan YK, Hatzis V, March L, Little CB, Tonkin M, Jackson CJ., Free PMC Article | 09/26/2015 |
| expression of PLA2s-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves | The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.
Suzuki K, Takahashi S, Watanabe K, Fujioka D, Nakamura T, Obata JE, Kawabata K, Katoh R, Matsumoto M, Kugiyama K. | 09/5/2015 |
| Summarizing, Der p1 and Fel d1 involve phospholipase A2 enzymes in their action. | The step further to understand the role of cytosolic phospholipase A2 alpha and group X secretory phospholipase A2 in allergic inflammation: pilot study.
Pniewska E, Sokolowska M, Kupryś-Lipińska I, Przybek M, Kuna P, Pawliczak R., Free PMC Article | 06/20/2015 |
| There is no association between rs525380 polymorphism of PLA2G5 and coronary heart disease. | Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.
Holmes MV, Exeter HJ, Folkersen L, Nelson CP, Guardiola M, Cooper JA, Sofat R, Boekholdt SM, Khaw KT, Li KW, Smith AJ, Van't Hooft F, Eriksson P, Franco-Cereceda A, Asselbergs FW, Boer JM, Onland-Moret NC, Hofker M, Erdmann J, Kivimaki M, Kumari M, Reiner AP, Keating BJ, Humphries SE, Hingorani AD, Mallat Z, Samani NJ, Talmud PJ, CARDIoGRAM Consortium., Free PMC Article | 03/21/2015 |
| Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD. In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD and hypertension. | The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study.
Vargas-Alarcón G, Posadas-Romero C, Villarreal-Molina T, Alvarez-León E, Angeles-Martinez J, Soto ME, Monroy-Muñoz I, Juárez JG, Sánchez-Ramírez CJ, Ramirez-Bello J, Ramírez-Fuentes S, Fragoso JM, Rodríguez-Pérez JM., Free PMC Article | 02/14/2015 |
| Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillindependent pathway. | Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin‑dependent pathway.
Rhee HJ, Ji L, Kim SH, Lee J. | 05/10/2014 |
| Our studies identified a unique function of gV-sPLA2 in activation of macrophages | Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Ohta S, Imamura M, Xing W, Boyce JA, Balestrieri B., Free PMC Article | 08/31/2013 |
| The effects of acidic pH on the activity of recombinant human group V secreted phospholipase A(2) (sPLA(2)-V) toward small VLDL (sVLDL), IDL, and LDL, on the binding of these apoB-100-containing lipoproteins to human aortic proteoglycans, were examined. | Acidity and lipolysis by group V secreted phospholipase A(2) strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans.
Lähdesmäki K, Öörni K, Alanne-Kinnunen M, Jauhiainen M, Hurt-Camejo E, Kovanen PT. | 04/14/2012 |
| Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina | Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina.
Sergouniotis PI, Davidson AE, Mackay DS, Lenassi E, Li Z, Robson AG, Yang X, Kam JH, Isaacs TW, Holder GE, Jeffery G, Beck JA, Moore AT, Plagnol V, Webster AR., Free PMC Article | 02/4/2012 |
| Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro | Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro.
Dudek SM, Muñoz NM, Desai A, Osan CM, Meliton AY, Leff AR., Free PMC Article | 04/30/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, Saxena S, Kapur S. | 04/7/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.
Wootton PT, Arora NL, Drenos F, Thompson SR, Cooper JA, Stephens JW, Hurel SJ, Hurt-Camejo E, Wiklund O, Humphries SE, Talmud PJ, Wootton PT, Arora NL, Drenos F, Thompson SR, Cooper JA, Stephens JW, Hurel SJ, Hurt-Camejo E, Wiklund O, Humphries SE, Talmud PJ. | 03/13/2008 |
| PLA2G5 tSNP haplotypes demonstrate an association with total and LDL cholesterol and oxLDL/LDL. | Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.
Wootton PT, Arora NL, Drenos F, Thompson SR, Cooper JA, Stephens JW, Hurel SJ, Hurt-Camejo E, Wiklund O, Humphries SE, Talmud PJ, Wootton PT, Arora NL, Drenos F, Thompson SR, Cooper JA, Stephens JW, Hurel SJ, Hurt-Camejo E, Wiklund O, Humphries SE, Talmud PJ. | 01/21/2010 |
| group V PLA2 released from neighboring cells may function in triggering the activation of inflammatory cells under physiological conditions | Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells.
Wijewickrama GT, Kim JH, Kim YJ, Abraham A, Oh Y, Ananthanarayanan B, Kwatia M, Ackerman SJ, Cho W. | 01/21/2010 |
| Group V phospholipase A2, endogenously secreted from activated epithelial cells, promotes secretion of leukotriene C4 from cocultured eosinophils. | Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils.
Muñoz NM, Meliton AY, Lambertino A, Boetticher E, Learoyd J, Sultan F, Zhu X, Cho W, Leff AR. | 01/21/2010 |
| sPLA2-V expression in hepatocytes is induced by viral infection, fibrosis, and circulatory disturbance. Immunostaining using sPLA2-V antibody is useful for the detection of injured hepatocytes in patients with liver diseases. | Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease.
Ito M, Ishikawa Y, Kiguchi H, Komiyama K, Murakami M, Kudo I, Akasaka Y, Ishii T. | 01/21/2010 |
| foam cell formation is promoted by a SR-A- and CD36-independent process that involves cellular proteoglycans and Group V secretory phospholipase A2-modified low density lipoprotein | Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans.
Boyanovsky BB, van der Westhuyzen DR, Webb NR. | 01/21/2010 |