| PKNOX1 acts as a transcription factor of DHH and promotes the progression of stomach adenocarcinoma by regulating the Hedgehog signalling pathway. | PKNOX1 acts as a transcription factor of DHH and promotes the progression of stomach adenocarcinoma by regulating the Hedgehog signalling pathway.
Liu B, Zhao S, Liu L., Free PMC Article | 11/8/2023 |
| Polyunsaturated fatty acids ameliorate renal stone-induced renal tubular damage via miR-93-5p/Pknox1 axis. | Polyunsaturated fatty acids ameliorate renal stone-induced renal tubular damage via miR-93-5p/Pknox1 axis.
Liu Q, Tang J, Chen Z, Wei L, Chen J, Xie Z. | 12/17/2022 |
| Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis. | Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis.
Bruckmann C, Tamburri S, De Lorenzi V, Doti N, Monti A, Mathiasen L, Cattaneo A, Ruvo M, Bachi A, Blasi F., Free PMC Article | 01/9/2021 |
| These data implicate the upregulated hepatic expression of Pknox1 in type 2 diabetes mellitus (T2DM) complicated with nonalcoholic fatty liver disease (NAFLD) may be caused by the reduced expression of miR-17 family, indicating that developing miRNA-mediated regulation strategies on Pknox1 may provide new therapeutic options for metabolic disease | MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling.
Ye D, Lou G, Zhang T, Dong F, Liu Y., Free PMC Article | 11/2/2019 |
| the replication timing of a specific fraction of the human genome is affected by PREP1 tumor suppressor | PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry.
Palmigiano A, Santaniello F, Cerutti A, Penkov D, Purushothaman D, Makhija E, Luzi L, di Fagagna FD, Pelicci PG, Shivashankar V, Dellino GI, Blasi F., Free PMC Article | 10/19/2019 |
| PREP1 modulates the cellular sensitivity to TGF-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation. | Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.
Risolino M, Mandia N, Iavarone F, Dardaei L, Longobardi E, Fernandez S, Talotta F, Bianchi F, Pisati F, Spaggiari L, Harter PN, Mittelbronn M, Schulte D, Incoronato M, Di Fiore PP, Blasi F, Verde P., Free PMC Article | 04/25/2015 |
| High levels of MEIS1 and PREP1, and low levels of PBX4 expression were founded in samples of patients with ALL. | MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.
Rosales-Aviña JA, Torres-Flores J, Aguilar-Lemarroy A, Gurrola-Díaz C, Hernández-Flores G, Ortiz-Lazareno PC, Lerma-Díaz JM, de Celis R, González-Ramella Ó, Barrera-Chaires E, Bravo-Cuellar A, Jave-Suárez LF., Free PMC Article | 08/18/2012 |
| Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia | Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.
Bol SM, Booiman T, van Manen D, Bunnik EM, van Sighem AI, Sieberer M, Boeser-Nunnink B, de Wolf F, Schuitemaker H, Portegies P, Kootstra NA, van 't Wout AB., Free PMC Article | 08/4/2012 |
| The tumor suppressor role of Prep1 is associated with the maintenance of genomic stability. | Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.
Iotti G, Longobardi E, Masella S, Dardaei L, De Santis F, Micali N, Blasi F., Free PMC Article | 10/8/2011 |
| analysis of the regulatory region of the zebrafish Prep1.1 gene and the promoter of human PREP1 | Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.
Bernardi E, Deflorian G, Pezzimenti F, Diaz VM, Mione M, Blasi F., Free PMC Article | 07/9/2011 |
| Immunohistochemistry on tissue micrroarrays (TMA) generated from three distinct human cohorts comprising a total of some 1000 human tumors revealed that 70% of the tumors express no or extremely low levels of Prep1, unlike normal tissues. | Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1.
Longobardi E, Iotti G, Di Rosa P, Mejetta S, Bianchi F, Fernandez-Diaz LC, Micali N, Nuciforo P, Lenti E, Ponzoni M, Doglioni C, Caniatti M, Di Fiore PP, Blasi F., Free PMC Article | 06/28/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of biochemical traits in Korcula Island, Croatia.
Zemunik T, Boban M, Lauc G, Janković S, Rotim K, Vatavuk Z, Bencić G, Dogas Z, Boraska V, Torlak V, Susac J, Zobić I, Rudan D, Pulanić D, Modun D, Mudnić I, Gunjaca G, Budimir D, Hayward C, Vitart V, Wright AF, Campbell H, Rudan I., Free PMC Article | 03/25/2009 |
| Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. | Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.
Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X., Free PMC Article | 01/21/2010 |
| PKNOX1 gene-dosage imbalance is associated with overexpression of FABP7 in Down syndrome fetal brains. | Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance.
Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G., Free PMC Article | 01/21/2010 |
| PREP-1 has a role in F9 teratocarcinoma cells: it causes an increase of PBX-2 by preventing its degradation | Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation.
Longobardi E, Blasi F. | 01/21/2010 |
| PREP1 regulates PF4 gene expression. | PREP1, MEIS1 homolog protein, regulates PF4 gene expression.
Okada Y, Matsuura E, Nagai R, Sato T, Watanabe A, Morita I, Doi T. | 01/21/2010 |