| Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis. | Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis.
Urbaniak A, Jablonska K, Suchanski J, Partynska A, Szymczak-Kulus K, Matkowski R, Maciejczyk A, Ugorski M, Dziegiel P., Free PMC Article | 04/26/2023 |
| Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients. | Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients.
Chivasso C, Nesverova V, Järvå M, Blanchard A, Rose KL, Öberg FK, Wang Z, Martin M, Lhotellerie F, Zindy E, Junqueira B, Leroy K, Vanhollebeke B, Delforge V, Bolaky N, Perret J, Soyfoo MS, Moscato S, Baldini C, Chaumont F, Mattii L, Schey KL, Myal Y, Törnroth-Horsefield S, Delporte C., Free PMC Article | 11/22/2021 |
| Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells. | Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells.
Lee HW, Shin J, Wilson BS, Oh JW., Free PMC Article | 10/23/2021 |
| results suggest that PIP-positive and PIP-negative columnar cell lesions are likely to represent biologically distinct conditions and that apocrine changes might occur earlier than ER activation in the natural history of breast precursor lesions | Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N. | 05/9/2020 |
| Efficacy of GATA3 Versus BRST2 for the Identification of Metastatic Breast Carcinoma in the Upper GI Tract. | Efficacy of GATA3 Versus BRST2 for the Identification of Metastatic Breast Carcinoma in the Upper GI Tract: Which Performs Better?
Salagean D, Streutker C, Faragalla H, Jakate K. | 05/9/2020 |
| The increased vascular wall thickness in pulmonary hypertension secondary to pulmonary fibrosis patients is concomitant with a significantly increased expression of the transcription factor Slug within the macrophages and its target prolactin-induced protein. | Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis.
Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Cunningham CM, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M., Free PMC Article | 04/11/2020 |
| Conclusively, our results show that PIP levels are reduced in all three human biological fluids tested, and may independently or in combination with current imaging techniques aid in screening and diagnosis of keratoconus. | Prolactin-Induced Protein is a novel biomarker for Keratoconus.
Sharif R, Bak-Nielsen S, Sejersen H, Ding K, Hjortdal J, Karamichos D., Free PMC Article | 04/20/2019 |
| GATA-3 expression was the highest in luminal breast carcinomas, and showed higher sensitivity than GCDFP-15 and MGB. However, in the poorly differentiated IBC, its utility was still limited. One should be aware of the possible GATA-3 expression in lung carcinomas. | GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer.
Ni YB, Tsang JYS, Shao MM, Chan SK, Cheung SY, Tong J, To KF, Tse GM. | 03/2/2019 |
| Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin. | Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin.
Sung YN, Park CS, Roh J, Choi JW, Choi SH, Lee Y, Cho KJ. | 01/26/2019 |
| Unusual N-type glycosylation of salivary prolactin-inducible protein (PIP): multiple Lewis(Y) epitopes generate highly-fucosylated glycan structures. | Unusual N-type glycosylation of salivary prolactin-inducible protein (PIP): multiple Lewis(Y) epitopes generate highly-fucosylated glycan structures.
Wiegandt A, Behnken HN, Meyer B. | 12/22/2018 |
| that GATA3 is a very sensitive marker for primary genital extramammary Paget diseases and is more sensitive than gross cystic disease fluid protein 15 | GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15.
Zhao M, Zhou L, Sun L, Song Y, Guo Y, Zhang X, Zhao F, Wang P, Yue J, Niu D, Li Z, Huang X, Kang Q, Jia L, Lai J, Cao D., Free PMC Article | 04/14/2018 |
| monoclonal antibodies to GATA-3 are very sensitive reagents for the identification of breast CA, surpassing antibodies to GCDFP-15 and mammaglobin A, and offer a significant improvement in identifying TNBCs | Comparative Sensitivities and Specificities of Antibodies to Breast Markers GCDFP-15, Mammaglobin A, and Different Clones of Antibodies to GATA-3: A Study of 338 Tumors Using Whole Sections.
Kandalaft PL, Simon RA, Isacson C, Gown AM. | 08/5/2017 |
| good coincidence was observed between primary and metastatic tumor GATA3 expression (kappa value = 0.826 >0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75) and mammaglobin (kappa value =0.593 <0.75) | GATA3 expression in clinically useful groups of breast carcinoma: a comparison with GCDFP15 and mammaglobin for identifying paired primary and metastatic tumors.
Yang Y, Lu S, Zeng W, Xie S, Xiao S. | 03/11/2017 |
| High expression of GCDFP-15 is associated with molecular apocrine breast cancer. | Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer.
Liu X, Feng C, Liu J, Zhao L, Liu J, Zhang W, Liu N, Niu Y. | 02/18/2017 |
| While highly expressed under pathological conditions of the mammary gland, including breast cancers, PIP is expressed in very few other cancers. Although the function of PIP is not well elucidated, numerous studies suggest that its primary role may be related to host defense and immune modulation. Studies in Pip null mice suggest that PIP may play a similar immune-regulatory role in breast cancer. [Review] | Prolactin-Inducible Protein: From Breast Cancer Biomarker to Immune Modulator-Novel Insights from Knockout Mice.
Ihedioha OC, Shiu RP, Uzonna JE, Myal Y. | 12/31/2016 |
| novel marker GATA3 stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples | The Novel Marker GATA3 is Significantly More Sensitive Than Traditional Markers Mammaglobin and GCDFP15 for Identifying Breast Cancer in Surgical and Cytology Specimens of Metastatic and Matched Primary Tumors.
Sangoi AR, Shrestha B, Yang G, Mego O, Beck AH., Free PMC Article | 12/17/2016 |
| In summary, this study suggests that PIP expression regulates the process of cell adhesion in breast cancer. | Prolactin-Induced Protein regulates cell adhesion in breast cancer.
Vanneste M, Naderi A. | 04/23/2016 |
| GCDFP15 in stratum corneum is a potential marker for dysregulated sweating in atopic dermatitis. | Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.
Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y., Free PMC Article | 04/9/2016 |
| The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome. | GATA-binding protein 3, gross cystic disease fluid protein-15 and mammaglobin have distinct prognostic implications in different invasive breast carcinoma subgroups.
Ni YB, Tsang JY, Chan SK, Tse GM. | 03/19/2016 |
| Data indicate the potential role of Gross cystic disease fluid protein-15/prolactin-inducible protein (GCDFP-15/PIP) as a biomarker for keratoconus (KC)disease. | Gross cystic disease fluid protein-15/prolactin-inducible protein as a biomarker for keratoconus disease.
Priyadarsini S, Hjortdal J, Sarker-Nag A, Sejersen H, Asara JM, Karamichos D., Free PMC Article | 01/23/2016 |
| Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. | Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer.
Naderi A, Meyer M., Free PMC Article | 06/27/2015 |
| GCDFP-15 expression is higher in tumors with favorable prognostic features. GCDFP-15 expression is further a frequent feature of androgen receptor positive tumors and the molecular apocrine subtype. | Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes.
Darb-Esfahani S, von Minckwitz G, Denkert C, Ataseven B, Högel B, Mehta K, Kaltenecker G, Rüdiger T, Pfitzner B, Kittel K, Fiedler B, Baumann K, Moll R, Dietel M, Eidtmann H, Thomssen C, Loibl S., Free PMC Article | 04/11/2015 |
| PIP is a breast cancer-related protein that is expressed in a majority of breast tumors and has a significant function in the biology of this disease. [review] | Prolactin-induced protein in breast cancer.
Naderi A. | 04/11/2015 |
| we found that HER2 or GCDFP15 protein overexpression is a sensitive and specific tool to differentiate MA from BL in the context of ER negative tumors. | Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.
Lehmann-Che J, Hamy AS, Porcher R, Barritault M, Bouhidel F, Habuellelah H, Leman-Detours S, de Roquancourt A, Cahen-Doidy L, Bourstyn E, de Cremoux P, de Bazelaire C, Albiter M, Giacchetti S, Cuvier C, Janin A, Espié M, de Thé H, Bertheau P., Free PMC Article | 03/21/2015 |
| The roles of PIP in the related T47D breast cancer cell line, were investigated. | Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner.
Baniwal SK, Chimge NO, Jordan VC, Tripathy D, Frenkel B., Free PMC Article | 01/31/2015 |