PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers.
Daneshvar G, Boostani S, Moghanibashi M, Mohamadynejad P.

Lnc-PIK3R1, transcriptionally suppressed by YY1, inhibits hepatocellular carcinoma progression via the Lnc-PIK3R1/miR-1286/GSK3β axis.
Lyu P, Li F, Deng R, Wei Q, Lin B, Cheng L, Zhao B, Lu Z.

A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism.
Thapa N, Chen M, Cryns VL, Anderson R., Free PMC Article

Comparative genomic analysis of PIK3R1-mutated and wild-type breast cancers.
Cobleigh MA, Layng KV, Mauer E, Mahon B, Hockenberry AJ, Abukhdeir AM.

Clinicopathological analysis of rosette-forming glioneuronal tumors.
Liu J, Lin F, Sun Y, Liu X., Free PMC Article

Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
Miao Y, Liu J.

SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Xu K, Fei W, Gao W, Fan C, Li Y, Hong Y, Cui R.

FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Dobish KK, Wittorf KJ, Swenson SA, Bean DC, Gavile CM, Woods NT, Ghosal G, Hyde RK, Buckley SM., Free PMC Article

Role of PI3K/Akt/mTOR pathway-mediated macrophage autophagy in affecting the phenotype transformation of lung fibroblasts induced by silica dust exposure.
DU Y, Huang F, Guan L, Zeng M., Free PMC Article

The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.
Tsay A, Wang JC., Free PMC Article

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2.
Nguyen T, Lau A, Bier J, Cooke KC, Lenthall H, Ruiz-Diaz S, Avery DT, Brigden H, Zahra D, Sewell WA, Droney L, Okada S, Asano T, Abolhassani H, Chavoshzadeh Z, Abraham RS, Rajapakse N, Klee EW, Church JA, Williams A, Wong M, Burkhart C, Uzel G, Croucher DR, James DE, Ma CS, Brink R, Tangye SG, Deenick EK., Free PMC Article

PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy.
Tharin Z, Richard C, Derangère V, Ilie A, Arnould L, Ghiringhelli F, Boidot R, Ladoire S., Free PMC Article

The Impact of PIK3R1 Mutations and Insulin-PI3K-Glycolytic Pathway Regulation in Prostate Cancer.
Chakraborty G, Nandakumar S, Hirani R, Nguyen B, Stopsack KH, Kreitzer C, Rajanala SH, Ghale R, Mazzu YZ, Pillarsetty NVK, Lee GM, Scher HI, Morris MJ, Traina T, Razavi P, Abida W, Durack JC, Solomon SB, Vander Heiden MG, Mucci LA, Wibmer AG, Schultz N, Kantoff PW., Free PMC Article

Clinical and immunological assessment of APDS2 with features of the SHORT syndrome related to a novel mutation in PIK3R1 with reduced penetrance.
Szczawińska-Popłonyk A, Bernat-Sitarz K, Schwartzmann E, Piechota M, Badura-Stronka M.

Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants.
Hargreaves CE, Dhalla F, Patel AM, de Oteyza ACG, Bateman E, Miller J, Anzilotti C, Ayers L, Grimbacher B, Patel SY.

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors.
Liu Y, Wang D, Li Z, Li X, Jin M, Jia N, Cui X, Hu G, Tang T, Yu Q., Free PMC Article

Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer.
Ma L, Zhang D, Huang Z, Zheng R, Du M, Lv Q, Qin C, Chu H, Yuan L, Zhang Z.

Exosomal miR-21-5p derived from bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion by targeting PIK3R1.
Qi J, Zhang R, Wang Y., Free PMC Article

Association with Longevity of Phosphatidylinositol 3-Kinase Regulatory Subunit 1 Gene Variants Stems from Protection against Mortality Risk in Men with Cardiovascular Disease.
Donlon TA, Chen R, Masaki KH, Willcox BJ, Morris BJ.

Malignant transformation of salivary gland pleomorphic adenoma: proof of principle.
Valstar MH, Mast H, Ten Hove I, Moonen LR, Balm AJ, Smeele LE, Koljenović S, Dinjens WN, van Velthuysen MF., Free PMC Article

miR-92a promotes cervical cancer cell proliferation, invasion, and migration by directly targeting PIK3R1.
Wang Y, Chen A, Zheng C, Zhao L., Free PMC Article

Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases.
Li X, Lau AYT, Ng ASN, Aldehaiman A, Zhou Y, Ng PKS, Arold ST, Cheung LWT., Free PMC Article

Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation.
He S, Zhang W, Li X, Wang J, Chen X, Chen Y, Lai R., Free PMC Article

Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth.
Cottrell CE, Bender NR, Zimmermann MT, Heusel JW, Corliss M, Evenson MJ, Magrini V, Corsmeier DJ, Avenarius M, Dudley JN, Johnston JJ, Lindhurst MJ, Vigh-Conrad K, Davies OMT, Coughlin CC, Frieden IJ, Tollefson M, Zaenglein AL, Ciliberto H, Tosi LL, Semple RK, Biesecker LG, Drolet BA., Free PMC Article

PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits.
Wang Q, Zhang P, Zhang W, Zhang X, Chen J, Ding P, Li L, Lv X, Li L, Hu W., Free PMC Article