| SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs. | SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs.
Guo L, Zhang C. | 07/21/2023 |
| Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages. | Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Masui O, Corbel C, Nagao K, Endo TA, Kezuka F, Diabangouaya P, Nakayama M, Kumon M, Koseki Y, Obuse C, Koseki H, Heard E. | 02/4/2023 |
| Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis. | Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis.
Zhan Y, Zhang Y, Zhang S, Coughlan H, Baldoni PL, Jacquelot N, Cao WHJ, Preston S, Louis C, Rautela J, Pellegrini M, Wicks IP, Alexander WS, Harrison LC, Lew AM, Smyth GK, Nutt SL, Chopin M. | 03/5/2022 |
| INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes. | INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.
Chakraborty P, Magnuson T., Free PMC Article | 02/12/2022 |
| Here we show that CRISPR/Cas9-mediated inactivation of Suz12 cooperates with mutant JAK3 to drive T-cell transformation and T-cell acute lymphoblastic leukemia development | Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.
Broux M, Prieto C, Demeyer S, Vanden Bempt M, Alberti-Servera L, Lodewijckx I, Vandepoel R, Mentens N, Gielen O, Jacobs K, Geerdens E, Vicente C, de Bock CE, Cools J., Free PMC Article | 02/8/2020 |
| SUZ12 binds to CpG islands and this stable recruitment to genomic loci is essential for correct H3K27 methylation patterns. | Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K., Free PMC Article | 07/27/2019 |
| Nsd1 is a key modulator of PRC2 function required for regulating the demarcation of genome-wide H3K27me2 and H3K27me3 domains in embryonic stem cells. | The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.
Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G. | 02/9/2019 |
| we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes | MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.
Graham B, Marcais A, Dharmalingam G, Carroll T, Kanellopoulou C, Graumann J, Nesterova TB, Bermange A, Brazauskas P, Xella B, Kriaucionis S, Higgs DR, Brockdorff N, Mann M, Fisher AG, Merkenschlager M., Free PMC Article | 11/25/2017 |
| Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement. | The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.
Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V., Free PMC Article | 10/28/2017 |
| lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program. | lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.
He D, Wang J, Lu Y, Deng Y, Zhao C, Xu L, Chen Y, Hu YC, Zhou W, Lu QR., Free PMC Article | 07/29/2017 |
| in the skin epithelium, EED, Suz12, and Ezh1/2 function largely as subunits of the PRC2 complex and have roles in skin development | Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development.
Dauber KL, Perdigoto CN, Valdes VJ, Santoriello FJ, Cohen I, Ezhkova E., Free PMC Article | 07/22/2017 |
| Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells. | Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.
Lee SC, Miller S, Hyland C, Kauppi M, Lebois M, Di Rago L, Metcalf D, Kinkel SA, Josefsson EC, Blewitt ME, Majewski IJ, Alexander WS. | 10/10/2015 |
| Suz12-dependent recruitment of Tet1 contributes to epigenetic plasticity throughout cell differentiation. | Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.
Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S., Free PMC Article | 04/4/2015 |
| PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2. | Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.
Lee SC, Phipson B, Hyland CD, Leong HS, Allan RS, Lun A, Hilton DJ, Nutt SL, Blewitt ME, Smyth GK, Alexander WS, Majewski IJ. | 12/7/2013 |
| PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. | The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.
Shi J, Wang E, Zuber J, Rappaport A, Taylor M, Johns C, Lowe SW, Vakoc CR., Free PMC Article | 04/13/2013 |
| The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma. | Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein.
Studach LL, Menne S, Cairo S, Buendia MA, Hullinger RL, Lefrançois L, Merle P, Andrisani OM., Free PMC Article | 01/26/2013 |
| polycomb proteins BMI1 and SUZ12 are required for cell transformation induced by organic arsenic exposure | Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.
Kim HG, Kim DJ, Li S, Lee KY, Li X, Bode AM, Dong Z., Free PMC Article | 12/8/2012 |
| Data indicate that binding of EZH2, SUZ12 and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin. | Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers.
Abraham CG, Kulesza CA., Free PMC Article | 07/14/2012 |
| identify polycomb-like 2 and Polycomb Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb Repressive Complex 2 and polycomb-like 2] | Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.
Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL., Free PMC Article | 05/10/2011 |
| Data show that RARgamma is required for deposition of H2A.Z and Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand. | RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.
Amat R, Gudas LJ., Free PMC Article | 01/8/2011 |
| Quantitative mass spectrometry was used to investigate the effects of Suz12 deficiency on H3.2 and H3.3 from mouse embryonic stem cells. | Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.
Jung HR, Pasini D, Helin K, Jensen ON., Free PMC Article | 08/9/2010 |
| Suz12 are significantly downregulated during murine skin repair. | Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes.
Shaw T, Martin P., Free PMC Article | 01/21/2010 |
| Suz12 haploinsufficiency results in diverse malformations of the brain and neural tube | Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube.
Miró X, Zhou X, Boretius S, Michaelis T, Kubisch C, Alvarez-Bolado G, Gruss P. | 01/21/2010 |
| These results demonstrate that Snail1 recruits PRC2 component Suz12 to the CDH1 promoter and requires the activity of this complex to repress E-cadherin expression. | Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.
Herranz N, Pasini D, Díaz VM, Francí C, Gutierrez A, Dave N, Escrivà M, Hernandez-Muñoz I, Di Croce L, Helin K, García de Herreros A, Peiró S., Free PMC Article | 01/21/2010 |
| loss of Suz12 function enhances hematopoietic stem cell (HSC) activity | Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
Majewski IJ, Blewitt ME, de Graaf CA, McManus EJ, Bahlo M, Hilton AA, Hyland CD, Smyth GK, Corbin JE, Metcalf D, Alexander WS, Hilton DJ., Free PMC Article | 01/21/2010 |