| Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages. | Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages.
Zhang D, Wang M, Ma S, Liu M, Yu W, Zhang X, Liu T, Liu S, Ren X, Sun Q. | 08/19/2024 |
| RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1. | RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1.
Qiu Z, Wang C, Huang P, Yuan Y, Shi Y, Lin Z, Huang Z, Zuo D, Qiu J, He W, Shen J, Niu Y, Yuan Y, Li B., Free PMC Article | 12/20/2023 |
| PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti-PD-1 Immunotherapy. | PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti-PD-1 Immunotherapy.
Zheng Y, Wang Y, Lu Z, Wan J, Jiang L, Song D, Wei C, Gao C, Shi G, Zhou J, Fan J, Ke A, Zhou L, Cai J., Free PMC Article | 10/25/2023 |
| Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1. | Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1.
Luo JQ, Yang TW, Wu J, Lai HH, Zou LB, Chen WB, Zhou XM, Lv DJ, Cen SR, Long ZN, Mao YY, Zheng PX, Su XH, Xian ZY, Shu FP, Mao XM., Free PMC Article | 08/9/2023 |
| MicroRNA-324-3p inhibits osteosarcoma progression by suppressing PGAM1-mediated aerobic glycolysis. | MicroRNA-324-3p inhibits osteosarcoma progression by suppressing PGAM1-mediated aerobic glycolysis.
Weng Y, Duan W, Yu X, Wu F, Yang D, Jiang Y, Wu J, Wang M, Wang X, Shen Y, Zhang Y, Xu H., Free PMC Article | 06/7/2023 |
| Matrine induces hepatocellular carcinoma apoptosis and represses EMT and stemness through microRNA-299-3p/PGAM1 axis. | Matrine induces hepatocellular carcinoma apoptosis and represses EMT and stemness through microRNA-299-3p/PGAM1 axis.
Wang B, Wang H, Zhao Q, Lu F, Yan Z, Zhou F, Su Q. | 12/3/2022 |
| PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells. | PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells.
Feng Y, Zhang X, Zhang S, Xu S, Chen X, Zhou C, Xi Y, Xie X, Lu W. | 10/22/2022 |
| PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway. | PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway.
Liu M, Li R, Wang M, Liu T, Zhou Q, Zhang D, Wang J, Shen M, Ren X, Sun Q., Free PMC Article | 08/13/2022 |
| Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway. | Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway.
Zhang C, Li Y, Zhao W, Liu G, Yang Q., Free PMC Article | 09/4/2021 |
| T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. | T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.
Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A, Yorozuya T, Yamada T, Soga T, Shiraishi A, Yamashita M., Free PMC Article | 06/19/2021 |
| PGAM1, regulated by miR-3614-5p, functions as an oncogene by activating transforming growth factor-beta (TGF-beta) signaling in the progression of non-small cell lung carcinoma. | PGAM1, regulated by miR-3614-5p, functions as an oncogene by activating transforming growth factor-β (TGF-β) signaling in the progression of non-small cell lung carcinoma.
Li F, Yang H, Kong T, Chen S, Li P, Chen L, Cheng J, Cui G, Zhang G., Free PMC Article | 04/24/2021 |
| The aim of this review is to update scientific research network with cancer-specific role of PGAM1 to elucidate its capability as bonafide therapeutic target for cancer therapy. | Phosphoglycerate mutase 1 in cancer: A promising target for diagnosis and therapy.
Sharif F, Rasul A, Ashraf A, Hussain G, Younis T, Sarfraz I, Chaudhry MA, Bukhari SA, Ji XY, Selamoglu Z, Ali M. | 05/16/2020 |
| PGAM1 is thus a downstream effector of mTOR signaling pathway and mTOR-PGAM1 signaling cascade may contribute to the development of Warburg effect observed in cancer. | Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis.
Sun Q, Li S, Wang Y, Peng H, Zhang X, Zheng Y, Li C, Li L, Chen R, Chen X, Bai W, Jiang X, Liu L, Wei F, Wang B, Zhang Y, Li H, Ren X, Zhang H., Free PMC Article | 09/21/2019 |
| Knockdown of PGAM1 by siRNA in PC-3 and 22Rv1 prostate cancer cell lines inhibited cell proliferation, migration, and invasion and enhanced cancer cell apoptosis. In a nude mouse xenograft model, PGAM1 knockdown markedly suppressed tumor growth. Deletion of PGAM1 resulted in decreased expression of Bcl-2, enhanced expression of Bax, caspases-3 and inhibition of MMP-2 and MMP-9 expression. | Phosphoglycerate mutase 1 knockdown inhibits prostate cancer cell growth, migration, and invasion.
Wen YA, Zhou BW, Lv DJ, Shu FP, Song XL, Huang B, Wang C, Zhao SC., Free PMC Article | 05/18/2019 |
| High PGAM1 expression is associated with Pancreatic Ductal Adenocarcinoma Metastasis. | Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Liu X, Tan X, Liu P, Wu Y, Qian S, Zhang X., Free PMC Article | 11/10/2018 |
| conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1 | Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1.
Liu SE, Hu JC, Zhang H, Xu P, Wan W, Zheng MY, Yu KQ, Ding H, Jiang HL, Zhou L, Luo C., Free PMC Article | 07/28/2018 |
| When BPGM is knocked out, 1,3-BPG can directly phosphorylate PGAM1. In this case, PGAM1 phosphorylation and activity are decreased, but nevertheless sufficient to maintain normal glycolytic flux and cellular growth rate. | Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate.
Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD., Free PMC Article | 10/14/2017 |
| study provided the first evidence revealing a non-metabolic function of PGAM1 in promoting cell migration, and gained new insights into the role of PGAM1 in cancer progression. | Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity.
Zhang D, Jin N, Sun W, Li X, Liu B, Xie Z, Qu J, Xu J, Yang X, Su Y, Tang S, Han H, Chen D, Ding J, Tan M, Huang M, Geng M. | 09/16/2017 |
| Data show that tyrosine 26 phosphorylation enhances the binding of phosphoglycerate mutase 1 (PGAM1) to its substrates through generating electrostatic environment and structural features that are advantageous to the binding. | Molecular dynamics simulation reveals how phosphorylation of tyrosine 26 of phosphoglycerate mutase 1 upregulates glycolysis and promotes tumor growth.
Wang Y, Cai WS, Chen L, Wang G., Free PMC Article | 08/12/2017 |
| PGAM1 in promoting homologous recombination repair in tumor cell lines. Suggest potential therapeutic opportunity for PGAM1 inhibitors in combination with PARP inhibitors in cancer treatment. | Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M., Free PMC Article | 06/3/2017 |
| PGAM1 may be associated with the grade of glioma and be involved in the biological behavior of glioma cells. PGAM1 might be a novel therapeutic target in glioma. | The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma.
Xu Z, Gong J, Wang C, Wang Y, Song Y, Xu W, Liu Z, Liu Y. | 03/11/2017 |
| PGAM1 correlates with spermatogenic dysfunction and affects the function of cell proliferation, apoptosis and migration. | PGAM1 is Involved in Spermatogenic Dysfunction and Affects Cell Proliferation, Apoptosis, and Migration.
Zhang S, Zhao Y, Lei B, Li C, Mao X. | 10/8/2016 |
| Our finding showed that PGAM1 might serve as a promising therapeutic target for UBC. | Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer.
Peng XC, Gong FM, Chen Y, Qiu M, Cheng K, Tang J, Ge J, Chen N, Zeng H, Liu JY. | 10/1/2016 |
| PGAM1 is highly expressed in clear cell renal cell carcinoma and correlated with clinicalpathological features, which may contribute to tumor formation and progression. | Expression of PGAM1 in renal clear cell carcinoma and its clinical significance.
Li C, Shu F, Lei B, Lv D, Zhang S, Mao X., Free PMC Article | 08/20/2016 |
| PGAM is acetylated at lysines 100/106/113/138 in its central region, and a member of the Sirtuin family (class III deacetylase), SIRT2, is responsible for its deacetylation. | Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.
Tsusaka T, Guo T, Yagura T, Inoue T, Yokode M, Inagaki N, Kondoh H. | 05/16/2015 |