| Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis. | Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.
Jin M, Yuan T, Tian K, Li J, Huang Q, Chi Y, Huang G., Free PMC Article | 04/1/2024 |
| ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation. | ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.
Li S, Lv J, Zhang X, Zhang Q, Li Z, Lu J, Huo X, Guo M, Liu X, Gao R, Gong J, Li C, Li W, Zhang T, Wang J, Chen Z, Du X. | 09/8/2023 |
| MiR-200b-3p is upregulated in the placental tissues from patients with preeclampsia and promotes the development of preeclampsia via targeting profilin 2. | MiR-200b-3p is upregulated in the placental tissues from patients with preeclampsia and promotes the development of preeclampsia via targeting profilin 2.
Liu H, Wang X., Free PMC Article | 09/3/2022 |
| OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer. | OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer.
Obinata D, Funakoshi D, Takayama K, Hara M, Niranjan B, Teng L, Lawrence MG, Taylor RA, Risbridger GP, Suzuki Y, Takahashi S, Inoue S., Free PMC Article | 04/30/2022 |
| [Profilin 2 is highly expressed in gastric cancer and promotes tumor cell proliferation and migration]. | [Profilin 2 is highly expressed in gastric cancer and promotes tumor cell proliferation and migration].
Hu S, Shi L., Free PMC Article | 04/16/2022 |
| ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy. | ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
Lu L, Zhong Z, Gu J, Nan K, Zhu M, Miao C., Free PMC Article | 01/15/2022 |
| Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells. | Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells.
Ling Y, Cao Q, Liu Y, Zhao J, Zhao Y, Li K, Chen Z, Du X, Huo X, Kang H, Chen Z. | 10/9/2021 |
| Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes. | Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes.
Cao Q, Liu Y, Wu Y, Hu C, Sun L, Wang J, Li C, Guo M, Liu X, Lv J, Huo X, Yue J, Du X, Chen Z., Free PMC Article | 05/29/2021 |
| PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin. | PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin.
Ree R, Kind L, Kaziales A, Varland S, Dai M, Richter K, Drazic A, Arnesen T., Free PMC Article | 05/8/2021 |
| Long non-coding RNA TUG1 regulates the progression and metastasis of osteosarcoma cells via miR-140-5p/PFN2 axis. | Long non-coding RNA TUG1 regulates the progression and metastasis of osteosarcoma cells via miR-140-5p/PFN2 axis.
Zhao ZY, Zhao YC, Liu W. | 12/26/2020 |
| MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis. | MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.
Sangokoya C, Blelloch R., Free PMC Article | 10/31/2020 |
| Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics. | Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics.
Walter LM, Franz P, Lindner R, Tsiavaliaris G, Hensel N, Claus P. | 10/3/2020 |
| Results suggest that PFN2 promotes the proliferation and metastasis of HNSC by activating the PI3K/Akt/beta-catenin signaling pathway. | Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-Catenin Signaling Pathway.
Zhou K, Chen J, Wu J, Xu Y, Wu Q, Yue J, Song Y, Li S, Zhou P, Tu W, Yang G, Jiang S., Free PMC Article | 03/21/2020 |
| hPIV-2 V protein promotes F-actin formation by affecting actin-profilin2 interaction through its binding to profilin2. | Profilin2 is required for filamentous actin formation induced by human parainfluenza virus type 2.
Ohta K, Matsumoto Y, Nishio M. | 11/9/2019 |
| We unveil PFN2 and GAMT as molecular determinants of Charcot-Marie-Tooth type 2 neuropathy, with possible indications of the role of PFN2 in the pathogenesis and disease progression. | PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease.
Juneja M, Azmi A, Baets J, Roos A, Jennings MJ, Saveri P, Pisciotta C, Bernard-Marissal N, Schneider BL, Verfaillie C, Chrast R, Seeman P, Hahn AF, de Jonghe P, Maudsley S, Horvath R, Pareyson D, Timmerman V. | 10/5/2019 |
| Profilin 2 (PFN2) expression is significantly upregulated in Breast cancer (BC) tissues. The abnormal upregulation of PFN2 is associated with poor prognosis in patients with BC. Long noncoding RNA FOXD2 adjacent opposite strand RNA 1 and PFN2 expression is positively correlated. | Long non‑coding RNA FOXD2‑AS1/miR‑150‑5p/PFN2 axis regulates breast cancer malignancy and tumorigenesis.
Jiang M, Qiu N, Xia H, Liang H, Li H, Ao X. | 05/25/2019 |
| Pfn2 levels, regulated by cIAP1, affected intracellular levels of reactive oxygen species. | Ubiquitin-proteasome dependent regulation of Profilin2 (Pfn2) by a cellular inhibitor of apoptotic protein 1 (cIAP1).
Jeong DH, Choi YN, Seo TW, Lee JS, Yoo SJ. | 05/25/2019 |
| Study indicated that PFN2 may function as a negative regulator of colorectal cancer (CRC) metastasis and, thus, may represent a potential target for CRC therapy. | Loss of profilin 2 contributes to enhanced epithelial-mesenchymal transition and metastasis of colorectal cancer.
Zhang H, Yang W, Yan J, Zhou K, Wan B, Shi P, Chen Y, He S, Li D., Free PMC Article | 12/1/2018 |
| High PFN2 expression might serve as a valuable predictor for poor overall survival of HNSC. DNA amplification and hypomethylation might be two mechanisms of PFN2 dysregulation. | Bioinformatic analysis of PFN2 dysregulation and its prognostic value in head and neck squamous carcinoma.
Liu J, Wu Y, Wang Q, Liu X, Liao X, Pan J. | 08/18/2018 |
| PFN2 gene, related to regulation of actin cytoskeleton in protein complex F, might play momentous roles in the initiation and development of consecutive Trauma-Induced Sepsis. | Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis.
Dong L, Li H, Zhang S, Su L., Free PMC Article | 04/28/2018 |
| PFN2 has a novel role in promoting Esophageal squamous cell carcinoma progression and metastasis. | PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma.
Cui XB, Zhang SM, Xu YX, Dang HW, Liu CX, Wang LH, Yang L, Hu JM, Liang WH, Jiang JF, Li N, Li Y, Chen YZ, Li F., Free PMC Article | 10/21/2017 |
| Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression. | The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms.
Joy M, Gau D, Castellucci N, Prywes R, Roy P., Free PMC Article | 08/5/2017 |
| Study demonstrated that miR30a inhibits epithelial-mesenchymal transition (EMT) and invasion in highly invasive non-small cell lung cancer (NSCLC) cell lines via targeting PFN2 suggesting that miR30a with PFN2 may play an essential role in the development of NSCLC by modulating EMT and cell invasion. | MicroRNA-30a-5p suppresses epithelial-mesenchymal transition by targeting profilin-2 in high invasive non-small cell lung cancer cell lines.
Yan J, Ma C, Gao Y. | 05/13/2017 |
| Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. | Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.
Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI., Free PMC Article | 10/22/2016 |
| Therefore, this study indicates that profilin 2 affects the metastatic potential and stemness of colorectal CSCs by regulating EMT- and stemness-related proteins. | Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells.
Kim MJ, Lee YS, Han GY, Lee HN, Ahn C, Kim CW. | 05/7/2016 |