| The selenoprotein methionine sulfoxide reductase B1 (MSRB1). | The selenoprotein methionine sulfoxide reductase B1 (MSRB1).
Tarrago L, Kaya A, Kim HY, Manta B, Lee BC, Gladyshev VN. | 10/8/2022 |
| In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors. | Methionine sulfoxide reductase B1 regulates proliferation and invasion by affecting mitogen-activated protein kinase pathway and epithelial-mesenchymal transition in u2os cells.
Li H, He Q, Meng F, Feng X, Chen J, Li L, Liu J. | 02/24/2018 |
| FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention. | Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease.
Chen P, Wang C, Ma X, Zhang Y, Liu Q, Qiu S, Liu Q, Tian J, Ni J., Free PMC Article | 10/7/2017 |
| MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption. | Effect of methionine sulfoxide reductase B1 (SelR) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells.
Jia Y, Zhou J, Liu H, Huang K. | 05/8/2017 |
| findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells. | Selenoprotein X Gene Knockdown Aggravated H2O2-Induced Apoptosis in Liver LO2 Cells.
Tang J, Cao L, Li Q, Wang L, Jia G, Liu G, Chen X, Cai J, Shang H, Zhao H. | 01/28/2017 |
| Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress | Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Dai J, Liu H, Zhou J, Huang K., Free PMC Article | 11/5/2016 |
| Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. | Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.
Ugarte N, Ladouce R, Radjei S, Gareil M, Friguet B, Petropoulos I. | 07/25/2015 |
| MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS. | Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells.
Li Y, Jia Y, Zhou J, Huang K. | 03/30/2013 |
| The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress. | Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-induced apoptosis in human lens epithelial cells.
Jia Y, Li Y, Du S, Huang K. | 09/22/2012 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| Strong candidate gene for schizophrenia; upregulated in lymphoblastoid cells of monozygotic twins. | Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia.
Kakiuchi C, Ishiwata M, Nanko S, Ozaki N, Iwata N, Umekage T, Tochigi M, Kohda K, Sasaki T, Imamura A, Okazaki Y, Kato T. | 01/21/2010 |
| The neutrophils expressed the highest activity Msrs. Msrs are important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage. | Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes.
Achilli C, Ciana A, Rossi A, Balduini C, Minetti G. | 01/21/2010 |
| The studies in mouse show that MsrB is a selenoprotein that exhibits high specificity for reduction of the R forms of free and protein-bound methionine sulfoxide. | Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity.
Moskovitz J, Singh VK, Requena J, Wilkinson BJ, Jayaswal RK, Stadtman ER. | 03/4/2004 |