| CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway. | CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Gao D, Wang R, Gong Y, Yu X, Niu Q, Yang E, Fan G, Ma J, Chen C, Tao Y, Lu J, Wang Z. | 11/3/2023 |
| miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. | miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.
Zhuang Y, Wang S, Fei H, Ji F, Sun P., Free PMC Article | 03/13/2021 |
| MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. | MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
Liang Y, Zhu D, Hou L, Wang Y, Huang X, Zhou C, Zhu L, Wang Y, Li L, Gu Y, Luo M, Wang J, Meng X., Free PMC Article | 10/24/2020 |
| miR-1265 suppresses gastric cancer progression and oncogenic autophagy by reducing CAB39 expression and regulating the AMPK-mTOR signaling pathway. | MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.
Xu Z, Li Z, Wang W, Xia Y, He Z, Li B, Wang S, Huang X, Sun G, Xu J, Wang L, Zhang Q, Li Q, Lv J, Wang L, Zhang L, Zhang D, Xu H, Xu Z. | 02/8/2020 |
| The MO25 binding to SPAK and OSR1 is enhanced by serine phosphorylation in their highly conserved WEWS motif, which is located in their C-terminal domains. | C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.
Mehellou Y, Alamri MA, Dhiani BA, Kadri H. | 04/6/2019 |
| Upregulation of miR-451 expression suppressed the growth and invasion of glioma cells in vitro and in vivo by targeting CAB39 and modulating the mTOR/HIF-1a/VEGF signaling pathway. | MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39.
Nan Y, Guo H, Guo L, Wang L, Ren B, Yu K, Huang Q, Zhong Y. | 03/2/2019 |
| plays very important oncogenic roles in hepatocellular carcinoma pathogenesis and progression by activating the ERK signaling pathway | Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.
Jiang L, Yan Q, Fang S, Liu M, Li Y, Yuan YF, Li Y, Zhu Y, Qi J, Yang X, Kwong DLW, Guan XY. | 11/4/2017 |
| These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases. | Structural insights into the activation of MST3 by MO25.
Mehellou Y, Alessi DR, Macartney TJ, Szklarz M, Knapp S, Elkins JM., Free PMC Article | 08/31/2013 |
| Authors conclude that miR-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K/AKT pathway indirectly. | MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma.
Tian Y, Nan Y, Han L, Zhang A, Wang G, Jia Z, Hao J, Pu P, Zhong Y, Kang C., Free PMC Article | 09/1/2012 |
| MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. | MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR., Free PMC Article | 07/9/2011 |
| study describes structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 function | Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM., Free PMC Article | 01/25/2010 |
| ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. | ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM., Free PMC Article | 01/21/2010 |
| These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet separate from other polarity events. | Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H. | 01/21/2010 |
| STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 | C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
Fogarty S, Hardie DG., Free PMC Article | 01/21/2010 |