| PADI3 inhibits epithelial-mesenchymal transition by targeting CKS1-induced signal transduction in colon cancer. | PADI3 inhibits epithelial-mesenchymal transition by targeting CKS1-induced signal transduction in colon cancer.
Chai Z, Zhu C, Wang X, Zheng Y, Han F, Xie Q, Liu C. | 09/6/2024 |
| Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures. | Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.
Uysal-Onganer P, D'Alessio S, Mortoglou M, Kraev I, Lange S., Free PMC Article | 09/11/2021 |
| Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. | Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
Funabashi K, Sawata M, Nagai A, Akimoto M, Mashimo R, Takahara H, Kizawa K, Thompson PR, Ite K, Kitanishi K, Unno M. | 09/11/2021 |
| Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation. | Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
Coassolo S, Davidson G, Negroni L, Gambi G, Daujat S, Romier C, Davidson I., Free PMC Article | 04/13/2021 |
| Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines. | Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Uysal-Onganer P, MacLatchy A, Mahmoud R, Kraev I, Thompson PR, Inal JM, Lange S., Free PMC Article | 12/5/2020 |
| Mutations in PADI3, which encodes a protein that is essential to proper hair-shaft formation, were associated with Central Centrifugal Cicatricial Alopecia. | Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E. | 03/9/2019 |
| The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation. | Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.
Ü Basmanav FB, Cau L, Tafazzoli A, Méchin MC, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJP, Oprisoreanu AM, Wehner M, Thiele H, Altmüller J, Nürnberg P, Swan D, Houniet D, Büchner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC., Free PMC Article | 05/27/2017 |
| Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination. | Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.
Méchin MC, Cau L, Galliano MF, Daunes-Marion S, Poigny S, Vidaluc JL, Bessou-Touya S, Takahara H, Serre G, Duplan H, Simon M. | 12/17/2016 |
| We identified the presence of PADI3 mRNA expression in synovial tissue and PADI2 and PADI4 mRNA expressions in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.
Olivares-Martínez E, Hernández-Ramírez DF, Núñez-Álvarez CA, Cabral AR, Llorente L. | 10/8/2016 |
| The prevalence and extent of ILD was markedly higher among RA patients with anti-PAD3/4 cross-reactive antibodies, even after accounting for relevant confounders, particularly among ever smokers. | Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.
Giles JT, Darrah E, Danoff S, Johnson C, Andrade F, Rosen A, Bathon JM., Free PMC Article | 08/8/2015 |
| Crystals of PAD3 obtained using polyethylene glycol 400 as a precipitant diffracted to 2.95 A resolution using synchrotron radiation | Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase type III.
Unno M, Kizawa K, Ishihara M, Takahara H., Free PMC Article | 09/15/2012 |
| These results reveal the molecular bases of the expression specificity of PADI1 and PADI3 during keratinocyte differentiation through a long-range enhancer and support a model of PADI gene regulation depending on c-Jun-JunD competition. | Long-range enhancer differentially regulated by c-Jun and JunD controls peptidylarginine deiminase-3 gene in keratinocytes.
Adoue V, Chavanas S, Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. | 01/21/2010 |
| Peptidylarginine deiminase Intergenic Enhancer is a strong enhancer of the PADI3 promoter in Ca2+-differentiated epidermal keratinocytes, and requires bound | Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
Chavanas S, Adoue V, Méchin MC, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M., Free PMC Article | 01/21/2010 |
| cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) | Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle.
Kizawa K, Takahara H, Troxler H, Kleinert P, Mochida U, Heizmann CW. | 01/21/2010 |
| peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13 | Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.
Iida A, Nakamura Y. | 01/21/2010 |
| PAD3 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. | The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.
Méchin MC, Enji M, Nachat R, Chavanas S, Charveron M, Ishida-Yamamoto A, Serre G, Takahara H, Simon M., Free PMC Article | 01/21/2010 |
| PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region | NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.
Dong S, Kanno T, Yamaki A, Kojima T, Shiraiwa M, Kawada A, Méchin MC, Chavanas S, Serre G, Simon M, Takahara H., Free PMC Article | 01/21/2010 |
| PAD1 and 3 are able to modify filaggrin | Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.
Nachat R, Méchin MC, Takahara H, Chavanas S, Charveron M, Serre G, Simon M. | 01/21/2010 |