| MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells. | MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells.
Dai Y, Xu Y, Shen J, Hu C, Li X, Chen Y, Liu Y, Hu D. | 06/27/2024 |
| Reduced Ca[2+] mobilization in neonatal human platelets involves SARAF and pannexin-1. | Reduced Ca(2+) mobilization in neonatal human platelets involves SARAF and pannexin-1.
Rosado JA. | 03/15/2024 |
| Bidirectional regulation of calcium release-activated calcium (CRAC) channel by SARAF. | Bidirectional regulation of calcium release-activated calcium (CRAC) channel by SARAF.
Zomot E, Achildiev Cohen H, Dagan I, Militsin R, Palty R., Free PMC Article | 12/25/2021 |
| Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment. | Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment.
Uslu M, Albayrak E, Kocabaş F. | 04/13/2021 |
| Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca(2+) entry-mediated turnover of focal adhesions. | Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca(2+) entry-mediated turnover of focal adhesions.
Huang HK, Lin YH, Chang HA, Lai YS, Chen YC, Huang SC, Chou CY, Chiu WT., Free PMC Article | 08/15/2020 |
| Y316F mutation altered the pattern of interaction between STIM1 and SARAF under resting conditions and upon Ca(2+) store depletion. Expression of the STIM1 Y316F mutant enhanced slow Ca(2+)-dependent inactivation (SCDI) as compared to STIM1 WT, an effect that was abolished by SARAF knockdown. | STIM1 phosphorylation at Y(316) modulates its interaction with SARAF and the activation of SOCE and I(CRAC).
Lopez E, Frischauf I, Jardin I, Derler I, Muik M, Cantonero C, Salido GM, Smani T, Rosado JA, Redondo PC. | 07/25/2020 |
| Described is the X-ray crystal structure of the SARAF luminal domain, SARAFL. This domain forms a novel 10-stranded beta-sandwich fold that includes a set of three conserved disulfide bonds, denoted the "SARAF-fold." The structure reveals a domain-swapped dimer in which the last two beta-strands (beta9 and beta10) are exchanged forming a region denoted the "SARAF luminal switch" that is essential for dimerization. | SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.
Kimberlin CR, Meshcheriakova A, Palty R, Raveh A, Karbat I, Reuveny E, Minor DL Jr., Free PMC Article | 06/20/2020 |
| Study shows that SARAF interacted with STIM1 to limit Ca2+ influx during physiological stimulation, but interaction of SARAF with STIM1 was transient during pathological stimulation of acinar cells, resulting in sustained, toxic Ca2+ influx. Transgenic expression of SARAF in mouse pancreatic acini reduced pathologic Ca2+ influx, prevented inflammation, and reduced tissue damage in mouse models of severe pancreatitis. | Ca(2+) Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis.
Son A, Ahuja M, Schwartz DM, Varga A, Swaim W, Kang N, Maleth J, Shin DM, Muallem S. | 01/4/2020 |
| EFHB is a new store-operated Ca2+ entry regulator that modulates STIM1-SARAF interaction. | EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction.
Albarran L, Lopez JJ, Jardin I, Sanchez-Collado J, Berna-Erro A, Smani T, Camello PJ, Salido GM, Rosado JA. | 01/26/2019 |
| SARAF also interacts with Orai1 and TRPC1 in cells endogenously expressing STIM1 and cells with a low STIM1 expression and modulates channel function. This review focuses on the modulation by SARAF of SOCE and other forms of Ca(2+) influx mediated by Orai1 and TRPC1 in order to provide spatio-temporally regulated Ca(2+) signals. | Fine-tuning of store-operated calcium entry by fast and slow Ca(2+)-dependent inactivation: Involvement of SARAF.
Jardín I, Albarran L, Salido GM, López JJ, Sage SO, Rosado JA. | 07/14/2018 |
| This activation was sensitive to Src kinase inhibition, but not to CAMKII nor PKC inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src-Raf-MEK-ERK, rather than upstream regulators. | Store-operated calcium entry is dispensable for the activation of ERK1/2 pathway in prostate cancer cells.
Lopez-Guerrero AM, Pascual-Caro C, Martin-Romero FJ, Pozo-Guisado E. | 06/16/2018 |
| These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. | Role of STIM1 in the surface expression of SARAF.
Albarran L, Regodón S, Salido GM, Lopez JJ, Rosado JA., Free PMC Article | 10/21/2017 |
| SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner | SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner.
Albarrán L, López JJ, Gómez LJ, Salido GM, Rosado JA. | 06/24/2017 |
| SARAF overexpression attenuated store operated Ca2+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF silencing induced opposite effects. | Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry.
Albarran L, Lopez JJ, Amor NB, Martin-Cano FE, Berna-Erro A, Smani T, Salido GM, Rosado JA., Free PMC Article | 03/4/2017 |
| SARAF is constitutively expressed in the plasma membrane and interacts with Orai1. | Store-operated Ca2+ Entry-associated Regulatory factor (SARAF) Plays an Important Role in the Regulation of Arachidonate-regulated Ca2+ (ARC) Channels.
Albarran L, Lopez JJ, Woodard GE, Salido GM, Rosado JA., Free PMC Article | 08/6/2016 |
| Deletion of STIM1(448-490) and, in particular, STIM1(447-460) and STIM1(475-490) markedly enhances interaction of SARAF with STIM1. | The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function.
Jha A, Ahuja M, Maléth J, Moreno CM, Yuan JP, Kim MS, Muallem S., Free PMC Article | 09/14/2013 |
| Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. | Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients.
Lodola F, Laforenza U, Bonetti E, Lim D, Dragoni S, Bottino C, Ong HL, Guerra G, Ganini C, Massa M, Manzoni M, Ambudkar IS, Genazzani AA, Rosti V, Pedrazzoli P, Tanzi F, Moccia F, Porta C., Free PMC Article | 04/27/2013 |
| Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling by promoting a slow inactivation process of STIM2-dependent basal SOCE activity, as well as STIM1-mediated SOCE activity. | SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling.
Palty R, Raveh A, Kaminsky I, Meller R, Reuveny E. | 11/24/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |