| Exploring MPC1 as a potential ferroptosis-linked biomarker in the cervical cancer tumor microenvironment: a comprehensive analysis. | Exploring MPC1 as a potential ferroptosis-linked biomarker in the cervical cancer tumor microenvironment: a comprehensive analysis.
Li M, Xu T, Yang R, Wang X, Zhang J, Wu S., Free PMC Article | 10/18/2024 |
| Metabolism-focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer. | Metabolism-focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer.
Furusawa T, Cavero R, Liu Y, Li H, Xu X, Andresson T, Reinhold W, White O, Boufraqech M, Meyer TJ, Hartmann O, Diefenbacher ME, Pommier Y, Weyemi U., | 07/31/2024 |
| Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer. | Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer.
Farook MR, Croxford Z, Morgan S, Horlock AD, Holt AK, Rees A, Jenkins BJ, Tse C, Stanton E, Davies DM, Thornton CA, Jones N, Sheldon IM, Vincent EE, Cronin JG., Free PMC Article | 03/11/2024 |
| Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease. | Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Gao R, Li Y, Xu Z, Zhang F, Xu J, Hu Y, Yin J, Yang K, Sun L, Wang Q, He X, Huang K. | 11/16/2023 |
| Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming. | Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming.
Chen LC, Chen YJ, Lin HA, Chien WC, Tsai KJ, Chung CH, Wang JY, Chen CC, Liao NS, Shih CT, Lin YY, Huang CN, Ojcius DM, Huang KY, Lin HC. | 06/16/2023 |
| Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. | Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency.
Jiang H, Alahmad A, Fu S, Fu X, Liu Z, Han X, Li L, Song T, Xu M, Liu S, Wang J, Albash B, Alaqeel A, Catalina V, Prokisch H, Taylor RW, McFarland R, Fang F. | 05/14/2022 |
| Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes. | Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes.
Xu L, Phelix CF, Chen LY., Free PMC Article | 12/18/2021 |
| Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy. | Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy.
Zhu H, Wan H, Wu L, Li Q, Liu S, Duan S, Huang Z, Zhang C, Zhang B, Xing C, Yuan Y., Free PMC Article | 10/16/2021 |
| MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of beta-Catenin. | MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin.
Tian GA, Xu CJ, Zhou KX, Zhang ZG, Gu JR, Zhang XL, Wang YH., Free PMC Article | 06/12/2021 |
| Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases. | Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases.
Lee J, Jin Z, Lee D, Yun JH, Lee W., Free PMC Article | 02/27/2021 |
| The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier. | The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.
Zangari J, Petrelli F, Maillot B, Martinou JC., Free PMC Article | 02/13/2021 |
| A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. | A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Cui J, Quan M, Xie D, Gao Y, Guha S, Fallon MB, Chen J, Xie K. | 11/28/2020 |
| MPC1 was lowly expressed in lung adenocarcinoma tissues and positively correlated with overall survival of lung adenocarcinoma patients. MPC1 suppressed tumor progression via interacting with mito-STAT3, disrupting STAT3 distribution and inhibiting cyto-STAT3 activation. | MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway.
Zou H, Chen Q, Zhang A, Wang S, Wu H, Yuan Y, Wang S, Yu J, Luo M, Wen X, Cui W, Fu W, Yu R, Chen L, Zhang M, Lan H, Zhang X, Xie Q, Jin G, Xu C., Free PMC Article | 04/11/2020 |
| MPC1 deletion is associated with temozolomide resistance in glioblastoma. | MPC1 deletion is associated with poor prognosis and temozolomide resistance in glioblastoma.
Chai Y, Wang C, Liu W, Fan Y, Zhang Y. | 02/15/2020 |
| PGC1alpha reversed the Warburg effect by upregulating the expression of pyruvate dehydrogenase E1 alpha 1 subunit and mitochondrial pyruvate carrier 1 to increase pyruvate flux into the mitochondria for oxidation, whereas simultaneously promoting mitochondrial biogenesis and fusion to mediate the metabolic switch to oxidative phosphorylation. | PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect.
Dan Li, Wang C, Ma P, Yu Q, Gu M, Dong L, Jiang W, Pan S, Xie C, Han J, Lan Y, Sun J, Sheng P, Liu K, Wu Y, Liu L, Ma Y, Jiang H., Free PMC Article | 11/9/2019 |
| In contrast to MPC1, which co-purifies with a host chaperone, we demonstrated that MPC2 homo-oligomers promote efficient pyruvate transport into proteoliposomes. The derived functional requirements and kinetic features of MPC2 resemble those previously demonstrated for MPC in the literature | Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter.
Nagampalli RSK, Quesñay JEN, Adamoski D, Islam Z, Birch J, Sebinelli HG, Girard RMBM, Ascenção CFR, Fala AM, Pauletti BA, Consonni SR, de Oliveira JF, Silva ACT, Franchini KG, Leme AFP, Silber AM, Ciancaglini P, Moraes I, Dias SMG, Ambrosio ALB., Free PMC Article | 09/14/2019 |
| Studied role of mitochondrial pyruvate carrier 1 (MPC1) as a possible biomarker in the prognosis of renal cell carcinoma. | Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma.
Tang XP, Chen Q, Li Y, Wang Y, Zou HB, Fu WJ, Niu Q, Pan QG, Jiang P, Xu XS, Zhang KQ, Liu H, Bian XW, Wu XF. | 07/27/2019 |
| The mitochondrial pyruvate carrier (MPC) links glycolysis and mitochondrial metabolism. Retina-specific deletion of MPC1 results in progressive retinal degeneration and decline of visual function in both rod and cone photoreceptors. | Loss of MPC1 reprograms retinal metabolism to impair visual function.
Grenell A, Wang Y, Yam M, Swarup A, Dilan TL, Hauer A, Linton JD, Philp NJ, Gregor E, Zhu S, Shi Q, Murphy J, Guan T, Lohner D, Kolandaivelu S, Ramamurthy V, Goldberg AFX, Hurley JB, Du J., Free PMC Article | 05/4/2019 |
| The present study has shown that reduced MPC1 expression is involved in EMT in pancreatic cancer and CRC cell lines. Such changes have not been observed in MPC2. The tendency for MPC1 expression in carcinomas to be lower in comparison to normal cells promotes EMT through glutamine metabolism. | Mitochondrial pyruvate carrier 1 expression controls cancer epithelial-mesenchymal transition and radioresistance.
Takaoka Y, Konno M, Koseki J, Colvin H, Asai A, Tamari K, Satoh T, Mori M, Doki Y, Ogawa K, Ishii H., Free PMC Article | 04/20/2019 |
| The data demonstrated that CtBP1 directly bound to the promoters of MPC1 and MPC2 and transcriptionally repressed them, leading to increased levels of free NADH in the cytosol and nucleus, thus positively feeding back CtBP1's functions. | C-Terminal Binding Protein 1 Modulates Cellular Redox via Feedback Regulation of MPC1 and MPC2 in Melanoma Cells.
Deng Y, Li H, Yin X, Liu H, Liu J, Guo D, Shi Z., Free PMC Article | 01/12/2019 |
| Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells. | Hypoxia induces lactate secretion and glycolytic efflux by downregulating mitochondrial pyruvate carrier levels in human umbilical vein endothelial cells.
Wang D, Wang Q, Yan G, Qiao Y, Zhu B, Liu B, Tang C. | 11/3/2018 |
| Low MPC1 expression is associated with epithelial-mesenchymal transition in cholangiocarcinoma. | Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma.
Ohashi T, Eguchi H, Kawamoto K, Konno M, Asai A, Colvin H, Ueda Y, Takaoka H, Iwagami Y, Yamada D, Asaoka T, Noda T, Wada H, Gotoh K, Kobayashi S, Koseki J, Satoh T, Ogawa K, Doki Y, Mori M, Ishii H. | 09/1/2018 |
| Levels of lactate and mitochondrial pyruvate carrier (MPC1) mRNA were determined to scrutinize the prevalence of aerobic glycolysis..MT-RNR2 plays its anti-apoptotic role partly by avoiding deploying energy from complete oxidation of organic compounds to inorganic wastes. Thus MT-RNR2 can potentially serve as a new biomarker in the diagnosis of bladder carcinoma especially that it is present in blood circulation | Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
Omar NN, Tash RF, Shoukry Y, ElSaeed KO. | 03/17/2018 |
| Low MPC1 expression is associated with prostate cancer. | MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.
Wang L, Xu M, Qin J, Lin SC, Lee HJ, Tsai SY, Tsai MJ., Free PMC Article | 01/27/2018 |
| Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, the authors found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation. | A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).
Sandoval IT, Delacruz RG, Miller BN, Hill S, Olson KA, Gabriel AE, Boyd K, Satterfield C, Van Remmen H, Rutter J, Jones DA., Free PMC Article | 12/16/2017 |