| Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma. | Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.
Zhang K, Zhou J, Wu T, Tian Q, Liu T, Wang W, Zhong H, Chen Z, Xiao X, Wu G., Free PMC Article | 08/27/2022 |
| Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome with craniosynostosis. | Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome with craniosynostosis.
Nabais Sá MJ, Miller KA, McQuaid M, Koelling N, Wilkie AOM, Wurtele H, de Brouwer APM, Oliveira J., Free PMC Article | 08/6/2022 |
| GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1. | GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1.
Hu H, Ye L, Liu Z., Free PMC Article | 04/2/2022 |
| GINS Complex Subunit 2 Facilitates Gastric Adenocarcinoma Proliferation and Indicates Poor Prognosis. | GINS Complex Subunit 2 Facilitates Gastric Adenocarcinoma Proliferation and Indicates Poor Prognosis.
Feng H, Zeng J, Gao L, Zhou Z, Wang L. | 01/1/2022 |
| MicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2. | MicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2.
Zhan L, Yang J, Liu Y, Cheng Y, Liu H., Free PMC Article | 12/25/2021 |
| GINS2 was regulated by lncRNA XIST/miR-23a-3p to mediate proliferation and apoptosis in A375 cells. | GINS2 was regulated by lncRNA XIST/miR-23a-3p to mediate proliferation and apoptosis in A375 cells.
Hao YQ, Liu KW, Zhang X, Kang SX, Zhang K, Han W, Li L, Li ZH. | 08/7/2021 |
| GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway. | GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway.
He S, Zhang M, Ye Y, Song Y, Ma X, Wang G, Zhuang J, Xia W, Zhao B., Free PMC Article | 05/8/2021 |
| Knockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small-cell lung cancer. | Knockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small-cell lung cancer.
Chi F, Wang Z, Li Y, Chang N., Free PMC Article | 04/3/2021 |
| GINS2 facilitates epithelial-to-mesenchymal transition in non-small-cell lung cancer through modulating PI3K/Akt and MEK/ERK signaling. | GINS2 facilitates epithelial-to-mesenchymal transition in non-small-cell lung cancer through modulating PI3K/Akt and MEK/ERK signaling.
Liu X, Sun L, Zhang S, Zhang S, Li W. | 03/13/2021 |
| GINS2 is closely related to the occurrence and development of glioma, and is likely to become a prognostic marker for glioma patients, as well as a potential therapeutic target in the treatment of glioma | Loss of GINS2 inhibits cell proliferation and tumorigenesis in human gliomas.
Shen YL, Li HZ, Hu YW, Zheng L, Wang Q., Free PMC Article | 05/2/2020 |
| GINS2 plays an important role in cell proliferation and apoptosis of thyroid cancer by regulating the expressions of CITED2 and LOXL2, which may be a potential biomarker for diagnosis or prognosis and a drug target for therapy. | GINS2 promotes cell proliferation and inhibits cell apoptosis in thyroid cancer by regulating CITED2 and LOXL2.
Ye Y, Song YN, He SF, Zhuang JH, Wang GY, Xia W. | 04/4/2020 |
| mRNA expressions of all GINS subunits were significantly up-regulated in hepatocellular carcinoma tumor than in non-tumor liver tissues. | Up-regulated and interrelated expressions of GINS subunits predict poor prognosis in hepatocellular carcinoma.
Lian YF, Li SS, Huang YL, Wei H, Chen DM, Wang JL, Huang YH., Free PMC Article | 08/3/2019 |
| GINS2 plays a protective role in alcohol-induced brain injury | GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury.
Liu C, Wang R, Zhang Y. | 05/11/2019 |
| The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. | New insights into the GINS complex explain the controversy between existing structural models.
Carroni M, De March M, Medagli B, Krastanova I, Taylor IA, Amenitsch H, Araki H, Pisani FM, Patwardhan A, Onesti S., Free PMC Article | 10/20/2018 |
| GINS2 is overexpressed in cervical cancer.GINS2 is a novel indicator of pelvic lymph node metastasis in cervical cancer. | GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer.
Ouyang F, Liu J, Xia M, Lin C, Wu X, Ye L, Song L, Li J, Wang J, Guo P, He M., Free PMC Article | 06/24/2017 |
| silencing of GINS2 in triple negative breast cancer cells caused dramatic decrease of matrix metalloproteinase-9 (MMP9). | GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.
Peng L, Song Z, Chen D, Linghu R, Wang Y, Zhang X, Kou X, Yang J, Jiao S. | 02/18/2017 |
| High GINS2 transcript level is associated with endocrine therapy resistance in beast cancer. | High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients.
Zheng M, Zhou Y, Yang X, Tang J, Wei D, Zhang Y, Jiang JL, Chen ZN, Zhu P. | 07/25/2015 |
| On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation. | Effect of GINS2 on proliferation and apoptosis in leukemic cell line.
Zhang X, Zhong L, Liu BZ, Gao YJ, Gao YM, Hu XX., Free PMC Article | 05/24/2014 |
| GINS2 plays an important role in apoptosis and may function via the p38MAPK signaling pathway. | Roles of GINS2 in K562 human chronic myelogenous leukemia and NB4 acute promyelocytic leukemia cells.
Gao Y, Wang S, Liu B, Zhong L. | 11/16/2013 |
| Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products >10 kb in length. | Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
Kang YH, Galal WC, Farina A, Tappin I, Hurwitz J., Free PMC Article | 07/14/2012 |
| Data suggest that GINS2 to be associated with the aggressive characteristics of a subgroup of breast cancers in vivo. | Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2.
Rantala JK, Edgren H, Lehtinen L, Wolf M, Kleivi K, Vollan HK, Aaltola AR, Laasola P, Kilpinen S, Saviranta P, Iljin K, Kallioniemi O., Free PMC Article | 03/12/2011 |