| Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination. | Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.
Han MM, Hirakawa M, Yamauchi M, Matsuda N. | 02/12/2022 |
| Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway. | Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway.
Xing Z, Wang X, Liu J, Liu G, Zhang M, Feng K, Wang X., Free PMC Article | 10/2/2021 |
| PIAS4, upregulated in hepatocellular carcinoma, promotes tumorigenicity and metastasis. | PIAS4, upregulated in hepatocellular carcinoma, promotes tumorigenicity and metastasis.
Liu Q, Zhou B, Liao R, Zhou X, Yan X. | 07/10/2021 |
| Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASgamma. | Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ.
Dodat F, Cotnoir-White D, Dianati E, Vallet A, Mader S, Lévesque D. | 04/24/2021 |
| Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis. | Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis.
Son MJ, Rho SB, Kim K, Oh M, Son C, Song SY, Park K., Free PMC Article | 03/28/2021 |
| Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. | Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.
Zhang JM, Genois MM, Ouyang J, Lan L, Zou L., Free PMC Article | 03/20/2021 |
| Further definition of the proximal 19p13.3 microdeletion/microduplication syndrome and implication of PIAS4 as the major contributor. | Further definition of the proximal 19p13.3 microdeletion/microduplication syndrome and implication of PIAS4 as the major contributor.
Tenorio J, Nevado J, González-Meneses A, Arias P, Dapía I, Venegas-Vega CA, Calvente M, Hernández A, Landera L, Ramos S, SOGRI Consortium, Cigudosa JC, Pérez-Jurado LA, Lapunzina P. | 02/6/2021 |
| These findings suggest that PIASy binds to MafA through the SAP domain and negatively regulates the insulin gene promoter through a novel SIM1-dependent mechanism. | PIASy is a SUMOylation-independent negative regulator of the insulin transactivator MafA.
Onishi S, Kataoka K. | 06/13/2020 |
| PIASy-enhanced accumulation of SUMO1-conjugated proteins may contribute to its inducing effect of autophagy. | Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells.
Ran M, Chen H, Liang B, Liao W, Jiang J, Huang J, Ning C, Zang N, Zhou B, Liao Y, Liu H, Qin F, Yang Q, Li J, Ho W, Liang H, Ye L., Free PMC Article | 11/16/2019 |
| PIASgamma regulates HNF-1A SUMOylation with functional implications | The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α.
Kaci A, Keindl M, Solheim MH, Njølstad PR, Bjørkhaug L, Aukrust I., Free PMC Article | 11/2/2019 |
| Study reported that RIF1 is SUMOlyated in response to DNA damage and identified PIAS4 as the primary SUMO E3 ligase required for the SUMOylation of RIF1 protein. Mammalian cells compromised of PIAS4 expression, show impaired RIF1 SUMOylation and defective for the disassembly of DNA damage responsive RIF1 foci. | Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.
Kumar R, Cheok CF., Free PMC Article | 07/20/2019 |
| Investigation of the mechanisms responsible for the alcohol action revealed that alcohol enhanced the expression of protein inhibitor of activated STAT (PIASy) and overexpression of PIASy compromised anti-hepatitis C virus ability of IFN-lambda1. | Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.
Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H. | 04/20/2019 |
| study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses | Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.
Yu X, Chen H, Zuo C, Jin X, Yin Y, Wang H, Jin M, Ozato K, Xu S., Free PMC Article | 10/27/2018 |
| In the present study, the protein inhibitor of activated STAT Y (PIASy) was identified as a novel Isl1-interacting protein. Furthermore, PIASy and Isl1 upregulate insulin gene expression and insulin secretion in a dose-dependent manner by activating the insulin promoter. | Protein Inhibitor of Activated STAT Y (PIASy) Regulates Insulin Secretion by Interacting with LIM Homeodomain Transcription Factor Isl1.
Yan C, Yu C, Zhang D, Cui Y, Zhou J, Cui S., Free PMC Article | 06/23/2018 |
| post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. | A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.
Choi HJ, Kwon S, Kim DW. | 12/2/2017 |
| new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4. | Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.
Lear T, McKelvey AC, Rajbhandari S, Dunn SR, Coon TA, Connelly W, Zhao JY, Kass DJ, Zhang Y, Liu Y, Chen BB., Free PMC Article | 07/22/2017 |
| these findings provide evidence for the effects of PIAsxalpha and its mechanism on osteosarcoma progression, which offers novel insight into sumoylation and the cell cycle in osteosarcoma. | Protein inhibitor of activated STAT xα depresses cyclin D and cyclin D kinase, and contributes to the inhibition of osteosarcoma cell progression.
Wang J, Ni J, Yi S, Song D, Ding M. | 10/29/2016 |
| PIAS4 was identified as a candidate gene for abnormal head size in 13 patients with proximal 19p13.3 submicroscopic rearrangements . | PIAS4 is associated with macro/microcephaly in the novel interstitial 19p13.3 microdeletion/microduplication syndrome.
Nevado J, Rosenfeld JA, Mena R, Palomares-Bralo M, Vallespín E, Ángeles Mori M, Tenorio JA, Gripp KW, Denenberg E, Del Campo M, Plaja A, Martín-Arenas R, Santos-Simarro F, Armengol L, Gowans G, Orera M, Sanchez-Hombre MC, Corbacho-Fernández E, Fernández-Jaén A, Haldeman-Englert C, Saitta S, Dubbs H, Bénédicte DB, Li X, Devaney L, Dinulos MB, Vallee S, Crespo MC, Fernández B, Fernández-Montaño VE, Rueda-Arenas I, de Torres ML, Ellison JW, Raskin S, Venegas-Vega CA, Fernández-Ramírez F, Delicado A, García-Miñaúr S, Lapunzina P., Free PMC Article | 08/27/2016 |
| Our data reveal a novel and dynamic role for PIAS4 in the cellular-mediated restriction of herpesviruses and establish a new functional role for the PIAS family of SUMO ligases in the intrinsic antiviral immune response to DNA virus infection. | Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response.
Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C., Free PMC Article | 08/27/2016 |
| PIAS4 activity are required for the AMPKalpha1 SUMOylation and the inhibition of AMPKalpha1 activity towards mTORC1 signalling. | SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling.
Yan Y, Ollila S, Wong IPL, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP., Free PMC Article | 07/2/2016 |
| PIAS4 (rs735842) and VEGFA (rs699947) were the most statistically significant variants associated in hypoxia pathway analysis. | Identification of gene variants associated with hypoxia pathway in acute coronary syndrome: a pilot study.
Gokkusu C, Cakmakoglu B, Cincin ZB, Karaagac M, Emet S, Tamer S, Umman B. | 06/11/2016 |
| PIASgamma-dependent modification of tomosyn-1 with SUMO-2/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment. | Tomosyn interacts with the SUMO E3 ligase PIASγ.
Geerts CJ, Jacobsen L, van de Bospoort R, Verhage M, Groffen AJ., Free PMC Article | 04/2/2016 |
| SUMOylation of RXRalpha is significantly enhanced through PIAS4-mediated activity. | Distinct functional modes of SUMOylation for retinoid X receptor alpha.
Lee WP, Jena S, Rodriguez EP, O'Donovan SP, Wagner C, Jurutka PW, Thompson PD. | 10/3/2015 |
| High reactive oxygen speciesinduces oxidation and ubiquitin-mediated degradation of PIASgamma, thereby disrupting PIASgamma-IKKgamma cross talk. | ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors.
Mohanty S, Saha S, Md S Hossain D, Adhikary A, Mukherjee S, Manna A, Chakraborty S, Mazumdar M, Ray P, Das K, Chakraborty J, Sa G, Das T., Free PMC Article | 09/6/2014 |
| Human melanoma patient samples and cell lines maintain p53 expression but PIASy and/or Tip60 are frequently lost. | Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma.
Lakhter AJ, Kanginakudru S, Warren S, Touloukian CE, Boissy RE, Naidu SR. | 05/3/2014 |