| LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. | LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
Yan P, Li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu Z, Liu J, Sun K, Chen F, Zhang Y, Zeng C, Huang Y, Zhang B. | 02/19/2022 |
| Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins. | Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
Basu R, Eichhorn CD, Cheng R, Peterson RD, Feigon J., Free PMC Article | 01/1/2022 |
| LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. | LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.
Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. | 12/25/2021 |
| Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies. | Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
Zhang J, Yu R, Guo X, Zou Y, Chen S, Zhou K, Chen Y, Li Y, Gao S, Wu Y., Free PMC Article | 11/27/2021 |
| Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism. | Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism.
Kazemi G, Peymani F, Mohseni M, Zare Ashrafi F, Arzhangi S, Ardalani F, Aghakhani Moghaddam F, Kahrizi K, Najmabadi H. | 10/9/2021 |
| Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood. | Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.
Das S, Godbole K, Abraham SSC, Ganesan P, Kamdar P, Danda S. | 08/14/2021 |
| Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome. | Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome.
Gana S, Plumari M, Rossi E, Saracino A, Iorio M, Zanaboni MP, Orcesi S, Valente EM. | 06/26/2021 |
| L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. | L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B. | 05/15/2021 |
| LARP7 functios as a bridging factor for snoRNA-guided modification of the U6 snRNA and alterations in splicing fidelity contribute to the etiology of the Alazami syndrome. | The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness.
Hasler D, Meduri R, Bąk M, Lehmann G, Heizinger L, Wang X, Li ZT, Sement FM, Bruckmann A, Dock-Bregeon AC, Merkl R, Kalb R, Grauer E, Kunstmann E, Zavolan M, Liu MF, Fischer U, Meister G. | 07/11/2020 |
| LARP7 may have inhibited the proliferation and increased the radioiodine uptake of PTC cells by regulating the SHH signaling pathway. | LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway.
Sui X, Sui Y, Wang Y., Free PMC Article | 09/29/2018 |
| a structural model for Larp7 binding to the 7SK 3' end and mechanism for 7SK RNP assembly. This work provides insight into how this domain contributes to 7SK recognition and assembly of the core 7SK RNP. | Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7.
Eichhorn CD, Yang Y, Repeta L, Feigon J., Free PMC Article | 09/15/2018 |
| LARP7 knockdown induces progressive time-dependent telomere shortening concomitant with a reduction in telomerase enzymatic activity and a decrease in full-length (catalytically active) TERT mRNA in vitro, and that humans with LARP7 deficiency display dramatically short telomeres, borderline anemia in younger generations, and anticipation consistent with a telomeropathy. | Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency.
Holohan B, Kim W, Lai TP, Hoshiyama H, Zhang N, Alazami AM, Wright WE, Meyn MS, Alkuraya FS, Shay JW., Free PMC Article | 09/2/2017 |
| The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes. | The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.
Egloff S, Vitali P, Tellier M, Raffel R, Murphy S, Kiss T., Free PMC Article | 07/1/2017 |
| protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7. | Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective.
Martinez-Zapien D, Saliou JM, Han X, Atmanene C, Proux F, Cianférani S, Dock-Bregeon AC. | 06/28/2016 |
| results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5'-end with the foot of the 3' hairpin and has thus functional implications | Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Uchikawa E, Natchiar KS, Han X, Proux F, Roblin P, Zhang E, Durand A, Klaholz BP, Dock-Bregeon AC., Free PMC Article | 06/27/2015 |
| LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. | LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.
Ji X, Lu H, Zhou Q, Luo K., Free PMC Article | 05/16/2015 |
| LARP7 is most likely recruited to the HIV-1 promoter in the presence of hnRNP A1. | 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts.
Mizutani T, Ishizaka A, Suzuki Y, Iba H. | 06/28/2014 |
| The results demonstrate that the La modules of the human LARP7 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. | Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7.
Hussain RH, Zawawi M, Bayfield MA., Free PMC Article | 12/7/2013 |
| Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. | Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.
Wang W, Yao X, Huang Y, Hu X, Liu R, Hou D, Chen R, Wang G., Free PMC Article | 07/20/2013 |
| Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism | Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.
Alazami AM, Al-Owain M, Alzahrani F, Shuaib T, Al-Shamrani H, Al-Falki YH, Al-Qahtani SM, Alsheddi T, Colak D, Alkuraya FS. | 07/6/2013 |
| LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation. | LARP7 is a potential tumor suppressor gene in gastric cancer.
Cheng Y, Jin Z, Agarwal R, Ma K, Yang J, Ibrahim S, Olaru AV, David S, Ashktorab H, Smoot DT, Duncan MD, Hutcheon DF, Abraham JM, Meltzer SJ, Mori Y., Free PMC Article | 09/15/2012 |
| 7SK RNA thus establishes gene-dependent plasticity between HMGA1 chromatin remodeling and transcription initiation and P-TEFb transcription elongation. | 7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.
Eilebrecht S, Benecke BJ, Benecke A. | 09/1/2012 |
| A combination of restrictive chromatin structures at the HIV long terminal repeat and limiting P-TEFb levels contribute to transcriptional silencing leading to latency in primary CD4(+) T cells. | Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction.
Tyagi M, Pearson RJ, Karn J., Free PMC Article | 07/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP., Free PMC Article | 06/30/2010 |
| Results suggest that LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. | The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.
Markert A, Grimm M, Martinez J, Wiesner J, Meyerhans A, Meyuhas O, Sickmann A, Fischer U., Free PMC Article | 01/21/2010 |