| Exploring the removal of Spo11 and topoisomerases from DNA breaks in S. cerevisiae by human Tyrosyl DNA Phosphodiesterase 2. | Exploring the removal of Spo11 and topoisomerases from DNA breaks in S. cerevisiae by human Tyrosyl DNA Phosphodiesterase 2.
Johnson D, Allison RM, Cannavo E, Cejka P, Harper JA, Neale MJ. | 09/21/2024 |
| Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. | Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia.
Zagnoli-Vieira G, Brazina J, Van Den Bogaert K, Huybrechts W, Molenaers G, Caldecott KW, Van Esch H., Free PMC Article | 08/25/2023 |
| A novel non-sense mutation in TDP2 causes spinocerebellar ataxia autosomal recessive 23 accompanied by bilateral upward gaze; report of a case and review of the literature. | A novel non-sense mutation in TDP2 causes spinocerebellar ataxia autosomal recessive 23 accompanied by bilateral upward gaze; report of a case and review of the literature.
Zoghi S, Khamirani HJ, Hassanipour H, Bostanian P, Masoudian R, Dastgheib SA. | 03/5/2022 |
| DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks. | DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.
Saha S, Sun Y, Huang SN, Baechler SA, Pongor LS, Agama K, Jo U, Zhang H, Tse-Dinh YC, Pommier Y., Free PMC Article | 10/16/2021 |
| Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23). | Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23).
Errichiello E, Zagnoli-Vieira G, Rizzi R, Garavelli L, Caldecott KW, Zuffardi O. | 06/19/2021 |
| Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases. | Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases.
Zagnoli-Vieira G, Caldecott KW. | 04/3/2021 |
| Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1). | Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1).
Tsuda M, Kitamasu K, Kumagai C, Sugiyama K, Nakano T, Ide H. | 03/13/2021 |
| Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation. | Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation.
Holmes AC, Zagnoli-Vieira G, Caldecott KW, Semler BL., Free PMC Article | 02/20/2021 |
| TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands. | TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.
Al Mahmud MR, Ishii K, Bernal-Lozano C, Delgado-Sainz I, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Cortés-Ledesma F, Sasanuma H., Free PMC Article | 11/21/2020 |
| Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
Schellenberg MJ, Appel CD, Riccio AA, Butler LR, Krahn JM, Liebermann JA, Cortés-Ledesma F, Williams RS., Free PMC Article | 09/12/2020 |
| This article reviews TDP1 and TDP2 in the context of mitochondrial DNA repair. [review] | Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair.
Huang SN, Pommier Y., Free PMC Article | 12/14/2019 |
| Data suggest that tyrosyl-DNA Phosphodiesterases 1 (TDP1) and 2 (TDP2) are promising therapeutic targets and their inhibitors are expected to significantly synergize the effects of current anti-tumor therapies [Review]. | Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.
Kawale AS, Povirk LF., Free PMC Article | 07/27/2019 |
| lack of TDP2 in the mitochondria reduces the mitochondria transcription levels in two different human cell lines. In addition to identifying a novel TDP2(S) isoform, our report demonstrates the presence and importance of both TDP2 isoforms in the mitochondria. | Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2(S) short isoform.
Huang SN, Dalla Rosa I, Michaels SA, Tulumello DV, Agama K, Khiati S, Jean SR, Baechler SA, Factor VM, Varma S, Murai J, Miller Jenkins LM, Kelley SO, Pommier Y., Free PMC Article | 02/9/2019 |
| Data indicate that tyrosyl-DNA phosphodiesterase 2 (TDP2) alone does not remove DNA topoisomerase II (TOP2)-DNA complexes from genomic DNA in vitro and that depletion of TDP2 in cells does not slow the removal of TOP2-DNA complexes. | Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.
Lee KC, Swan RL, Sondka Z, Padget K, Cowell IG, Austin CA., Free PMC Article | 11/3/2018 |
| TDP2 re-localizes from the nucleus to the cytoplasm of EMCV infected cells. | VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage.
Maciejewski S, Ullmer W, Semler BL., Free PMC Article | 06/2/2018 |
| These findings uncover a ZNF451-TDP2-catalyzed and SUMO2-modulated pathway for direct resolution of TOP2 cleavage complex. | ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
Schellenberg MJ, Lieberman JA, Herrero-Ruiz A, Butler LR, Williams JG, Muñoz-Cabello AM, Mueller GA, London RE, Cortés-Ledesma F, Williams RS., Free PMC Article | 03/10/2018 |
| TDP2 suppresses chromosome rearrangements induced by TOP2 and reduces TOP2-induced chromosome translocations that arise during gene transcription. | TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW., Free PMC Article | 12/16/2017 |
| Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions. | Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. | 09/2/2017 |
| Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. | ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
Bian K, Muppani NR, Elkhadragy L, Wang W, Zhang C, Chen T, Jung S, Seternes OM, Long W., Free PMC Article | 01/28/2017 |
| Data show that DNA-repair enzyme TDP2 knockdown in HepG2 cells significantly delays the conversion of relaxed circular DNA (RC-DNA) to covalently closed circular (ccc) DNA. | Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses.
Königer C, Wingert I, Marsmann M, Rösler C, Beck J, Nassal M., Free PMC Article | 05/2/2015 |
| This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 and TDP2, as well as the relevance of TDP1 and TDP2 as determinants of response to anticancer agents | Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).
Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C., Free PMC Article | 02/14/2015 |
| Proteolytic degradation of Top2 enables the processing of Top2.DNA and Top2.RNA covalent complexes by TDP2. | Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).
Gao R, Schellenberg MJ, Huang SY, Abdelmalak M, Marchand C, Nitiss KC, Nitiss JL, Williams RS, Pommier Y., Free PMC Article | 10/18/2014 |
| TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. | TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW. | 06/21/2014 |
| Mutations in the 5'-tyrosyl-DNA phosphodiesterase activity of TTRAP,in particular TTRAP(E152A), showed decreased inhibitory activity on cell growth. | Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.
Zhou C, Shen Q, Xue J, Ji C, Chen J., Free PMC Article | 08/31/2013 |
| Magnesium is indispensable for a 5'-tyrosyl DNA phosphodiesterase activity. | Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction.
Adhikari S, Karmahapatra SK, Karve TM, Bandyopadhyay S, Woodrick J, Manthena PV, Glasgow E, Byers S, Saha T, Uren A., Free PMC Article | 01/12/2013 |