| GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma. | GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma.
Yan G, Li G, Gao X, Liu J, Li Y, Li J, Zhou H., Free PMC Article | 05/8/2024 |
| GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma. | GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.
Xie C, Xiang W, Shen H, Shen J., Free PMC Article | 02/26/2022 |
| Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation. | Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation.
Singh D, Schmidt N, Müller F, Bange T, Bird AW. | 01/29/2022 |
| GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling. | GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.
Zhang F, Meng J, Jiang H, Feng X, Wei D, Meng W., Free PMC Article | 12/18/2021 |
| Downregulation of GTSE1 leads to the inhibition of proliferation, migration, and Warburg effect in cervical cancer by blocking LHDA expression. | Downregulation of GTSE1 leads to the inhibition of proliferation, migration, and Warburg effect in cervical cancer by blocking LHDA expression.
Chen L, Zhong Y, Yang X, Zhang Q, Wu X. | 11/22/2021 |
| MiR-509-3-5p inhibits colon cancer malignancy by suppressing GTSE1. | MiR-509-3-5p inhibits colon cancer malignancy by suppressing GTSE1.
Li K. | 11/22/2021 |
| GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells. | GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Li SS, Chen DM, Chen LB, Wei H, Wang JL, Xiao J, Huang YH, Lian YF., Free PMC Article | 10/23/2021 |
| G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/beta-catenin signaling via modulation of GSK-3beta. | G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/β-catenin signaling via modulation of GSK-3β.
Guo W, Zhu J, Zhu Y, Wang K. | 08/21/2021 |
| GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway. | GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.
Lai W, Zhu W, Li X, Han Y, Wang Y, Leng Q, Li M, Wen X. | 08/7/2021 |
| GTSE1, together with CDC20, PCNA, and MCM6, may synergistically promote adverse prognosis in hepatocellular carcinoma by activating cell cycle. | GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.
Zheng Y, Shi Y, Yu S, Han Y, Kang K, Xu H, Gu H, Sang X, Chen Y, Wang J., Free PMC Article | 08/13/2020 |
| Authors found that GTSE1 could regulate the p53 function to alter the cell cycle distribution dependent on the mutation state of p53. Results reveal that GTSE1 played a key role in the progression of breast cancer. | GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
Lin F, Xie YJ, Zhang XK, Huang TJ, Xu HF, Mei Y, Liang H, Hu H, Lin ST, Luo FF, Lang YH, Peng LX, Qian CN, Huang BJ., Free PMC Article | 08/24/2019 |
| Knockdown of GTSE1 obviously suppressed the proliferation, migration, and invasion capacity whereas increasing GTSE1 led to the opposite trend, which suggested that GTSE1 could serve as a potential therapeutic target for bladder cancer. GTSE1 overexpression in bladder cancer might participate in the regulation of FoxM1/CCNB1 expression via the induction of the transfer of p53 to cytoplasm | Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation, migration, and invasion via regulating p53/FoxM1/CCNB1 pathway and predicts poor prognosis in bladder cancer.
Liu A, Zeng S, Lu X, Xiong Q, Xue Y, Tong L, Xu W, Sun Y, Zhang Z, Xu C. | 04/20/2019 |
| High expression of GTSE1 is commonly noted in hepatocellular carcinoma (HCC) and is closely correlated with migration and invasion by epithelial-to-mesenchymal transition modulation. Activated GTSE1 significantly interferes with chemotherapy efficacy and influences the probability of survival of patients with HCC. | GTSE1 promotes cell migration and invasion by regulating EMT in hepatocellular carcinoma and is associated with poor prognosis.
Wu X, Wang H, Lian Y, Chen L, Gu L, Wang J, Huang Y, Deng M, Gao Z, Huang Y., Free PMC Article | 01/19/2019 |
| G2 and S-phase expressed 1 (GTSE1) expression promotes AM progression and correlates with clinical outcomes of patients with acral melanoma (AM), and may represent a promising therapeutic target to suppress AM progression. | High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis.
Xu T, Ma M, Chi Z, Si L, Sheng X, Cui C, Dai J, Yu S, Yan J, Yu H, Wu X, Tang H, Yu J, Kong Y, Guo J., Free PMC Article | 06/23/2018 |
| GTSE1 is expressed exclusively in late G2 and M phase. From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover. | GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms.
Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ., Free PMC Article | 10/7/2017 |
| Results indicated for the first time that overexpression of GTSE1 was involved in the progress of HCC, enhancing proliferation and promoting cell invasion in HCC cells. | Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.
Guo L, Zhang S, Zhang B, Chen W, Li X, Zhang W, Zhou C, Zhang J, Ren N, Ye Q., Free PMC Article | 09/23/2017 |
| GTSE1 inhibition of MCAK activity regulates the balance of MT stability that determines the fidelity of chromosome alignment, segregation, and chromosomal stability. | GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.
Bendre S, Rondelet A, Hall C, Schmidt N, Lin YC, Brouhard GJ, Bird AW., Free PMC Article | 06/3/2017 |
| Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients. | GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells.
Subhash VV, Tan SH, Tan WL, Yeo MS, Xie C, Wong FY, Kiat ZY, Lim R, Yong WP., Free PMC Article | 05/14/2016 |
| GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. | GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
Scolz M, Widlund PO, Piazza S, Bublik DR, Reber S, Peche LY, Ciani Y, Hubner N, Isokane M, Monte M, Ellenberg J, Hyman AA, Schneider C, Bird AW., Free PMC Article | 06/15/2013 |
| GTSE1 is overexpressed dramatically in lung cancer patients' tissues. | Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer.
Tian T, Zhang E, Fei F, Li X, Guo X, Liu B, Li J, Chen Z, Xing J. | 09/1/2012 |
| Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization. | Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.
Liu XS, Li H, Song B, Liu X., Free PMC Article | 10/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel. | Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment.
Bublik DR, Scolz M, Triolo G, Monte M, Schneider C., Free PMC Article | 03/15/2010 |
| GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function | The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.
Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C. | 01/21/2010 |