| TH1L involvement in colorectal cancer pathogenesis by regulation of CCL20 through the NF-kappaB signalling pathway. | TH1L involvement in colorectal cancer pathogenesis by regulation of CCL20 through the NF-κB signalling pathway.
Wang S, Sun Y, Li C, Chong Y, Ai M, Wang Y, Shi H, Shang Y., Free PMC Article | 06/5/2024 |
| Structural basis of the human negative elongation factor NELF-B/C/E ternary complex. | Structural basis of the human negative elongation factor NELF-B/C/E ternary complex.
Cao Y, Qin Y, Zhang W, Tian W, Ren Y, Ren J, Wang J, Wang M, Jiang J, Wang Z. | 09/11/2023 |
| NELFCD polymorphisms are associated with jaundice-stage progression in primary biliary cholangitis. | NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.
Nishida N, Aiba Y, Hitomi Y, Kawashima M, Kojima K, Kawai Y, Ueno K, Nakamura H, Yamashiki N, Tanaka T, Tamura S, Mori A, Yagi S, Soejima Y, Yoshizumi T, Takatsuki M, Tanaka A, Harada K, Shimoda S, Komori A, Eguchi S, Maehara Y, Uemoto S, Kokudo N, Nagasaki M, Tokunaga K, Nakamura M., Free PMC Article | 11/30/2019 |
| A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo. | Architecture and RNA binding of the human negative elongation factor.
Vos SM, Pöllmann D, Caizzi L, Hofmann KB, Rombaut P, Zimniak T, Herzog F, Cramer P., Free PMC Article | 11/25/2017 |
| data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei | Cellular dynamics of the negative transcription elongation factor NELF.
Yung TM, Narita T, Komori T, Yamaguchi Y, Handa H. | 11/17/2012 |
| Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. | Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration.
Wu W, Sun Z, Wu J, Peng X, Gan H, Zhang C, Ji L, Xie J, Zhu H, Ren S, Gu J, Zhang S., Free PMC Article | 05/19/2012 |
| TH1 might play an important role in regulation of proliferation and invasion in human breast cancer. | Negative role of trihydrophobin 1 in breast cancer growth and migration.
Zou W, Yang Y, Wu Y, Sun L, Chi Y, Wu W, Yun X, Xie J, Gu J., Free PMC Article | 10/23/2010 |
| These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes. | Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation.
Yang Y, Zou W, Kong X, Wang H, Zong H, Jiang J, Wang Y, Hong Y, Chi Y, Xie J, Gu J. | 06/28/2010 |
| diverse transcriptional consequence of NELF-mediated RNAPII pausing in the human genome | Human negative elongation factor activates transcription and regulates alternative transcription initiation.
Sun J, Li R., Free PMC Article | 03/29/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.
Pal P, Mihanović M, Molnar S, Xi H, Sun G, Guha S, Jeran N, Tomljenović A, Malnar A, Missoni S, Deka R, Rudan P., Free PMC Article | 09/16/2009 |
| TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration. | Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration.
Cheng C, Kong X, Wang H, Gan H, Hao Y, Zou W, Wu J, Chi Y, Yang J, Hong Y, Chen K, Gu J., Free PMC Article | 01/21/2010 |
| Maternal serum Th1 cytokines concentrations increase in preterm and term delivery. | [Maternal serum Th1 and Th2 cytokines in preterm and term delivery].
Jarocki S, Redźko S, Przepieść J, Urban J. | 01/21/2010 |
| Trihydrophobin 1 negatively regulates A-Raf kinase | Trihydrophobin 1 is a new negative regulator of A-Raf kinase.
Liu W, Shen X, Yang Y, Yin X, Xie J, Yan J, Jiang J, Liu W, Wang H, Sun M, Zheng Y, Gu J. | 01/21/2010 |
| Negative elongation factor (NELF) is a four subunit transcription factor. Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and suggest that NELF is a new factor that coordinates mRNA processing in transcription. | NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Narita T, Yung TM, Yamamoto J, Tsuboi Y, Tanabe H, Tanaka K, Yamaguchi Y, Handa H. | 01/21/2010 |
| In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. | Identification of TH1 as an interaction partner of A-Raf kinase.
Yin XL, Chen S, Gu JX. | 01/21/2010 |
| A study was done of ubiquitin-dependent proeolysis of TH1L protein by E6-AP. | Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP).
Yang Y, Liu W, Zou W, Wang H, Zong H, Jiang J, Wang Y, Gu J. | 01/21/2010 |
| NELF-C and NELF-D are highly related or identical to the protein called TH1, of unknown function. NELF-B and NELF-C or NELF-D are integral subunits that bring NELF-A and NELF-E together. [NELF-B] [NELF-C] | Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H., Free PMC Article | 01/21/2010 |