| GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma. | GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
Hayashi M, Guida E, Inokawa Y, Goldberg R, Reis LO, Ooki A, Pilli M, Sadhukhan P, Woo J, Choi W, Izumchenko E, Gonzalez LM, Marchionni L, Zhavoronkov A, Brait M, Bivalacqua T, Baras A, Netto GJ, Koch W, Singh A, Hoque MO. | 11/6/2021 |
| Results indicate that GULP, engulfment adaptor PTB domain containing 1 (GULP1) threonine 35 (T35) phosphorylation is a mechanism for the regulation of GULP1-amyloid beta precursor protein (APP) interaction and thereby APP processing. | Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
Chau DD, Yung KW, Chan WW, An Y, Hao Y, Chan HE, Ngo JC, Lau KF., Free PMC Article | 06/13/2020 |
| the phagocytic adaptor protein Gulp1 regulates EphB/ephrinB trogocytosis to achieve efficient cell rearrangements of cultured cells and during embryonic development | Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development.
Gong J, Gaitanos TN, Luu O, Huang Y, Gaitanos L, Lindner J, Winklbauer R, Klein R., Free PMC Article | 05/16/2020 |
| The knockdown of GULP1 and ABR using siRNAs decreased phagocytosis by 40%. | Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.
Faralli JA, Desikan H, Peotter J, Kanneganti N, Weinhaus B, Filla MS, Peters DM., Free PMC Article | 04/25/2020 |
| GULP1 methylation was associated with clinicopathological parameters such as stage III/IV, poorly differentiated grade, residual disease, worse overall and disease specific survival in ovarian cancer. | Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.
Maldonado L, Brait M, Izumchenko E, Begum S, Chatterjee A, Sen T, Loyo M, Barbosa A, Poeta ML, Makarev E, Zhavoronkov A, Fazio VM, Angioli R, Rabitti C, Ongenaert M, Van Criekinge W, Noordhuis MG, de Graeff P, Wisman GBA, van der Zee AGJ, Hoque MO. | 09/14/2019 |
| This study highlights and provides new implications for the role of GULP1 associated molecular mechanism(s) in COPD-emphysema development or progression. | Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.
Datta S, Nam HS, Hayashi M, Maldonado L, Goldberg R, Brait M, Sidransky D, Illei P, Baras A, Vij N, Hoque MO. | 12/23/2017 |
| GULP1 only mediates LRP1 transactivation | Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA., Free PMC Article | 04/13/2013 |
| The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. | The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.
Jha A, Watkins SC, Traub LM., Free PMC Article | 11/24/2012 |
| GULP expression positively regulates TGF-beta signaling leading to growth inhibition, this may represent an attractive target to achieve TGF-beta responsiveness in ovarian cells. | Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells.
Ma CI, Martin C, Ma Z, Hafiane A, Dai M, Lebrun JJ, Kiss RS., Free PMC Article | 09/22/2012 |
| This study identify GULP1 as a novel neuronal amyloid-beta precursor protein interacting protein that alters trafficking and processing of amyloid-beta precursor protein. | Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.
Beyer AS, von Einem B, Schwanzar D, Keller IE, Hellrung A, Thal DR, Ingelsson M, Makarova A, Deng M, Chhabra ES, Pröpper C, Böckers TM, Hyman BT, von Arnim CA. | 06/16/2012 |
| overexpression of GULP1 enhanced the generation of APP CTFs (C-terminal fragments) and Abeta, whereas knockdown of GULP1 suppressed APP CTFs and Abeta production. | GULP1 is a novel APP-interacting protein that alters APP processing.
Hao Y, Perkinton MS, Chan WW, Chan HY, Miller CC, Lau KF. | 08/13/2011 |
| these results indicate that GULP functions as an adaptor protein for stabilin-1-mediated phagocytosis. | Adaptor protein GULP is involved in stabilin-1-mediated phagocytosis.
Park SY, Kim SY, Kang KB, Kim IS. | 09/13/2010 |
| the GULP1 gene and the apoptotic engulfment pathway are involved in schizophrenia in subjects of European ancestry | Apoptotic engulfment pathway and schizophrenia.
Chen X, Sun C, Chen Q, O'Neill FA, Walsh D, Fanous AH, Chowdari KV, Nimgaonkar VL, Scott A, Schwab SG, Wildenauer DB, Che R, Tang W, Shi Y, He L, Luo XJ, Su B, Edwards TL, Zhao Z, Kendler KS, Chen X, Sun C, Chen Q, O'Neill FA, Walsh D, Fanous AH, Chowdari KV, Nimgaonkar VL, Scott A, Schwab SG, Wildenauer DB, Che R, Tang W, Shi Y, He L, Luo XJ, Su B, Edwards TL, Zhao Z, Kendler KS., Free PMC Articles: PMC2731162, PMC2731162 | 02/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Apoptotic engulfment pathway and schizophrenia.
Chen X, Sun C, Chen Q, O'Neill FA, Walsh D, Fanous AH, Chowdari KV, Nimgaonkar VL, Scott A, Schwab SG, Wildenauer DB, Che R, Tang W, Shi Y, He L, Luo XJ, Su B, Edwards TL, Zhao Z, Kendler KS, Chen X, Sun C, Chen Q, O'Neill FA, Walsh D, Fanous AH, Chowdari KV, Nimgaonkar VL, Scott A, Schwab SG, Wildenauer DB, Che R, Tang W, Shi Y, He L, Luo XJ, Su B, Edwards TL, Zhao Z, Kendler KS. | 09/16/2009 |
| Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton. | Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.
Osada Y, Sunatani T, Kim IS, Nakanishi Y, Shiratsuchi A. | 01/21/2010 |
| GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis | Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment.
Park SY, Kang KB, Thapa N, Kim SY, Lee SJ, Kim IS. | 01/21/2010 |
| Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). | Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).
Su HP, Nakada-Tsukui K, Tosello-Trampont AC, Li Y, Bu G, Henson PM, Ravichandran KS. | 01/21/2010 |