| The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells. | The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells.
Wang H, Li J, Yu K, Lu Y, Ma M, Li Y. | 10/22/2024 |
| The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms. | The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
Zhang Y, Zhang Y, Hutterer E, Hultin S, Bergman O, Kolbeinsdottir S, Jin H, Forteza MJ, Ketelhuth DFJ, Roy J, Hedin U, Enge M, Matic L, Eriksson P, Holmgren L., Free PMC Article | 10/7/2024 |
| AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches. | AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.
Rotoli D, Díaz-Flores L, Gutiérrez R, Morales M, Ávila J, Martín-Vasallo P., Free PMC Article | 02/19/2022 |
| AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. | AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
Hwang D, Kim M, Kim S, Kwon MR, Kang YS, Kim D, Kang HC, Lim DS., Free PMC Article | 01/15/2022 |
| AMOTL2knockdown promotes the proliferation, migration and invasion of glioma by regulating betacatenin nuclear localization. | AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.
Chen X, Lu Y, Guo G, Zhang Y, Sun Y, Guo L, Li R, Nan Y, Yang X, Dong J, Jin X, Huang Q., Free PMC Article | 12/4/2021 |
| AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. | AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
Cui R, Jiang N, Zhang M, Du S, Ou H, Ge R, Ma D, Zhang J. | 04/17/2021 |
| the localization of IQGAP1, AmotL2, and FKBP51 in malignant cells and tumor microenvironment of human GB tumors | IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.
Rotoli D, Morales M, Maeso MD, Ávila J, Pérez-Rodríguez ND, Mobasheri A, van Noorden CJF, Martín-Vasallo P., Free PMC Article | 06/13/2020 |
| these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention | Angiomotin-like 2 interacts with and negatively regulates AKT.
Han H, Yang B, Wang W. | 09/30/2017 |
| study reports for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition | Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.
Kim M, Kim M, Park SJ, Lee C, Lim DS., Free PMC Article | 10/22/2016 |
| mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling. | Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
Artinian N, Cloninger C, Holmes B, Benavides-Serrato A, Bashir T, Gera J., Free PMC Article | 11/7/2015 |
| AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients. | AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Mojallal M, Zheng Y, Hultin S, Audebert S, van Harn T, Johnsson P, Lenander C, Fritz N, Mieth C, Corcoran M, Lembo F, Hallström M, Hartman J, Mazure NM, Weide T, Grandér D, Borg JP, Uhlén P, Holmgren L. | 11/7/2015 |
| Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by preventing their nuclear translocation. | Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.
Hong W. | 03/29/2014 |
| These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot family members through direct phosphorylation. | Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation.
Chan SW, Lim CJ, Guo F, Tan I, Leung T, Hong W., Free PMC Article | 02/22/2014 |
| These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process. | Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.
Proszynski TJ, Sanes JR., Free PMC Article | 12/21/2013 |
| AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ. | AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells.
Lucci V, Di Palma T, D'Ambrosio C, Scaloni A, Zannini M. | 11/16/2013 |
| AMOTL2 is as a novel activator of LATS2. | Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
Paramasivam M, Sarkeshik A, Yates JR 3rd, Fernandes MJ, McCollum D., Free PMC Article | 02/11/2012 |
| Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells | Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.
Wang Y, Li Z, Xu P, Huang L, Tong J, Huang H, Meng A., Free PMC Article | 01/21/2012 |