| Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response. | Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response.
Scalavino V, Piccinno E, Labarile N, Armentano R, Giannelli G, Serino G., Free PMC Article | 09/19/2024 |
| Recent advances of Phosphodiesterase 4B in cancer. | Recent advances of Phosphodiesterase 4B in cancer.
Miao Y, Peng L, Chen Z, Hu Y, Tao L, Yao Y, Wu Y, Yang D, Xu T. | 03/31/2023 |
| Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop. | Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop.
Xu T, Xie M, Jing X, Jiang H, Wu X, Wang X, Shu Y., Free PMC Article | 02/11/2023 |
| Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. | Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Dixit D, Prager BC, Gimple RC, Miller TE, Wu Q, Yomtoubian S, Kidwell RL, Lv D, Zhao L, Qiu Z, Zhang G, Lee D, Park DE, Wechsler-Reya RJ, Wang X, Bao S, Rich JN. | 07/9/2022 |
| Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics. | Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics.
Moreira RG, Saraiva-Duarte JM, Pereira AC, Sosa-Macias M, Galaviz-Hernandez C, Santolalla ML, Magalhães WCS, Zolini C, Leal TP, Balázs Z, Llerena A, Gilman RH, Mill JG, Borda V, Guio H, O'Connor TD, Tarazona-Santos E, Rodrigues-Soares F., Free PMC Article | 06/25/2022 |
| qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus. | qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.
Raza W, Guo J, Qadir MI, Bai B, Muhammad SA., Free PMC Article | 03/5/2022 |
| Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease. | Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease.
Chen MY, Fan K, Zhao LJ, Wei JM, Gao JX, Li ZF., Free PMC Article | 11/13/2021 |
| circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1. | circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
Shen S, Yang Y, Shen P, Ma J, Fang B, Wang Q, Wang K, Shi P, Fan S, Fang X., Free PMC Article | 09/25/2021 |
| Cardiac Overexpression of PDE4B Blunts beta-Adrenergic Response and Maladaptive Remodeling in Heart Failure. | Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Karam S, Margaria JP, Bourcier A, Mika D, Varin A, Bedioune I, Lindner M, Bouadjel K, Dessillons M, Gaudin F, Lefebvre F, Mateo P, Lechène P, Gomez S, Domergue V, Robert P, Coquard C, Algalarrondo V, Samuel JL, Michel JB, Charpentier F, Ghigo A, Hirsch E, Fischmeister R, Leroy J, Vandecasteele G. | 09/4/2021 |
| Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. | Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
Meier SM, Trontti K, Purves KL, Als TD, Grove J, Laine M, Pedersen MG, Bybjerg-Grauholm J, Bækved-Hansen M, Sokolowska E, Mortensen PB, Hougaard DM, Werge T, Nordentoft M, Breen G, Børglum AD, Eley TC, Hovatta I, Mattheisen M, Mors O., Free PMC Article | 01/23/2021 |
| These findings suggest that the disruption of the Myc-PDE4B circuitry can be exploited in the treatment of B cell malignancies. | Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival.
Nam J, Kim DU, Kim E, Kwak B, Ko MJ, Oh AY, Park BJ, Kim YW, Kim A, Sun H, Jung Y, Lee JH, Shin HJ, Park I, Song DK, Jeong JY, Lee YH, Kim SW. | 05/30/2020 |
| in psoriatic arthritis, dysregulated miR-23a expression contributes to synovial inflammation through enhanced synovial fibroblasts activation, via PDE4B signalling | Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B.
Wade SM, Trenkmann M, McGarry T, Canavan M, Marzaioli V, Wade SC, Veale DJ, Fearon U. | 04/11/2020 |
| PDE4 genetic polymorphisms impact individual susceptibility to beta2-adrenergic receptor targeted therapy in patients with preterm labor. | Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.
Yee J, Hwang HS, Chung JE, Park JY, Lee KE, Kim YJ, Gwak HS. | 02/8/2020 |
| PDE4B gene may play a role in the pathogenesis of OLP. | Expression and significance of phosphodiesterase 4B gene in peripheral blood of patients with oral lichen planus.
Wang C, Li S, Shen C, Shan J, Fan Y. | 06/1/2019 |
| Study combined mutational analysis in the Apc mutated mice with published studies of frank colon cancer in patients to deduce that Pde4b has two strong biological functions. It negatively regulates colonic adenomagenesis in Apc mutated mice. In patients, PDE4B is most commonly inactivated by an epigenetic process. | The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.
Pleiman JK, Irving AA, Wang Z, Toraason E, Clipson L, Dove WF, Deming DA, Newton MA., Free PMC Article | 01/19/2019 |
| Data suggest that maternal glycemic response during pregnancy is associated with lower DNA methylation of 4 CpG sites within PDE4B gene in placenta (collected after term birth); 3 additional CpG sites are differentially methylated relative to maternal glucose response within TNFRSF1B, LDLR, and BLM genes. (TNFRSF1B = TNF receptor superfamily member-1B; LDLR = low density lipoprotein receptor; BLM = Bloom syndrome protein) | Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy.
Cardenas A, Gagné-Ouellet V, Allard C, Brisson D, Perron P, Bouchard L, Hivert MF. | 07/28/2018 |
| Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition. | Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.
Cai Y, Huang G, Ma L, Dong L, Chen S, Shen X, Zhang S, Xue R, Sun D, Zhang S. | 04/21/2018 |
| HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity. | Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.
Tanaka M, Ishizuka K, Nekooki-Machida Y, Endo R, Takashima N, Sasaki H, Komi Y, Gathercole A, Huston E, Ishii K, Hui KK, Kurosawa M, Kim SH, Nukina N, Takimoto E, Houslay MD, Sawa A., Free PMC Article | 09/16/2017 |
| Low PDE4B expression is associated with sepsis. | Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.
Lelubre C, Medfai H, Akl I, Leentjens J, Kox M, Pickkers P, Rousseau A, Biston P, Piagnerelli M, Vanhaeverbeek M, Uzureau P, Vincent JL, Vanhamme L, Boudjeltia KZ. | 09/16/2017 |
| PDE4B gene may be involved in the testicular abnormalities of men with DS and cryptorchidism. | Expression of Phosphodiesterase 4B cAMP-Specific Gene in Subjects With Cryptorchidism and Down's Syndrome.
Salemi M, Condorelli RA, La Vignera S, Castiglione R, Salluzzo MG, Bonaccorso CM, Vinci M, Bosco P, Romano C, Campagna C, Romano C, Calogero AE., Free PMC Article | 02/18/2017 |
| This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia. | Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies.
Feng Y, Cheng D, Zhang C, Li Y, Zhang Z, Wang J, Shi Y., Free PMC Article | 07/16/2016 |
| Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils | The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor.
Suzuki O, Goto T, Yoshino T, Nakamura S, Maeda H. | 02/27/2016 |
| Our results support previously reported association of PDE4B variations with schizophrenia in other populations. | Association analysis of PDE4B polymorphisms with schizophrenia and smooth pursuit eye movement abnormality in a Korean population.
Bae JS, Park BL, Cheong HS, Kim JH, Kim JY, Namgoong S, Kim JO, Park CS, Kim BJ, Lee CS, Kim JW, Choi WH, Shin TM, Hwang J, Koh IS, Shin HD, Woo SI. | 09/12/2015 |
| analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 | Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.
Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, Li JD., Free PMC Article | 07/4/2015 |
| ototopical post-inoculation administration of a PDE4 inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 | Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.
Komatsu K, Lee JY, Miyata M, Hyang Lim J, Jono H, Koga T, Xu H, Yan C, Kai H, Li JD., Free PMC Article | 10/26/2013 |