| Phosphodiesterase 2 and Its Isoform A as Therapeutic Targets in the Central Nervous System Disorders. | Phosphodiesterase 2 and Its Isoform A as Therapeutic Targets in the Central Nervous System Disorders.
Metkar SK, Yan Y, Lu Y, Lu J, Zhu X, Du F, Xu Y. | 08/4/2024 |
| The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling. | The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.
Carlantoni C, Liekfeld LMH, Hemkemeyer SA, Schreier D, Saygi C, Kurelic R, Cardarelli S, Kalucka J, Schulte C, Beerens M, Mailer RK, Schäffer TE, Naro F, Pellegrini M, Nikolaev VO, Renné T, Frye M. | 02/9/2024 |
| Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma. | Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma.
Chen L, Zhou J, Zhao Z, Zhu Y, Xing J, An J, Guo X., Free PMC Article | 01/21/2023 |
| miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/beta-catenin signaling. | miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling.
Li SZ, Ren KX, Zhao J, Wu S, Li J, Zang J, Fei Z, Zhao JL., Free PMC Article | 02/26/2022 |
| Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism. | Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.
Rassi-Cruz M, Maria AG, Faucz FR, London E, Vilela LAP, Santana LS, Benedetti AFF, Goldbaum TS, Tanno FY, Srougi V, Chambo JL, Pereira MAA, Cavalcante ACBS, Carnevale FC, Pilan B, Bortolotto LA, Drager LF, Lerario AM, Latronico AC, Fragoso MCBV, Mendonca BB, Zerbini MCN, Stratakis CA, Almeida MQ., Free PMC Article | 01/8/2022 |
| Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease. | Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease.
Farmer R, Burbano SD, Patel NS, Sarmiento A, Smith AJ, Kelly MP., Free PMC Article | 08/14/2021 |
| A Novel Inhibition Modality for Phosphodiesterase 2A. | A Novel Inhibition Modality for Phosphodiesterase 2A.
Nakashima K, Matsui H. | 07/17/2021 |
| Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy. | Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.
Lobo MJ, Reverte-Salisa L, Chao YC, Koschinski A, Gesellchen F, Subramaniam G, Jiang H, Pace S, Larcom N, Paolocci E, Pfeifer A, Zanivan S, Zaccolo M., Free PMC Article | 06/26/2021 |
| Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia. | Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia.
Doummar D, Dentel C, Lyautey R, Metreau J, Keren B, Drouot N, Malherbe L, Bouilleret V, Courraud J, Valenti-Hirsch MP, Minotti L, Dozieres-Puyravel B, Bär S, Scholly J, Schaefer E, Nava C, Wirth T, Nasser H, de Salins M, de Saint Martin A, Warde MTA, Kahane P, Hirsch E, Anheim M, Friant S, Chelly J, Mignot C, Rudolf G., Free PMC Article | 06/12/2021 |
| A Homozygous Splicing Mutation in PDE2A in a Family With Atypical Rett Syndrome. | A Homozygous Splicing Mutation in PDE2A in a Family With Atypical Rett Syndrome.
Haidar Z, Jalkh N, Corbani S, Abou-Ghoch J, Fawaz A, Mehawej C, Chouery E. | 05/8/2021 |
| the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity. | Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants.
Hernández-Ramírez LC, Trivellin G, Stratakis CA. | 12/16/2017 |
| Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool which can penetrate the blood brain barrier. | Characterisation of Lu AF33241: A novel, brain-penetrant, dual inhibitor of phosphodiesterase (PDE) 2A and PDE10A.
Redrobe JP, Rasmussen LK, Christoffersen CT, Bundgaard C, Jørgensen M. | 05/21/2016 |
| Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised beta-adrenergic Signaling in an induced pluripotent stem cell model of dilated cardiomyopathy. | Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC., Free PMC Article | 04/23/2016 |
| curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition | Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition.
Abusnina A, Keravis T, Zhou Q, Justiniano H, Lobstein A, Lugnier C. | 12/19/2015 |
| PDE2A is involved in growth and invasion of human malignant melanoma PMP cells. | Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.
Hiramoto K, Murata T, Shimizu K, Morita H, Inui M, Manganiello VC, Tagawa T, Arai N., Free PMC Article | 03/7/2015 |
| This study reports the X-ray crystal structure of PDE2A in complex with a highly selective, nanomolar inhibitor (BAY60-7550) at 1.9 A resolution, and the structure of apo PDE2 at 2.0 A resolution. | X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity.
Zhu J, Yang Q, Dai D, Huang Q. | 03/8/2014 |
| PDE2 overexpression in healthy cardiomyocytes reduces the rise in cyclic AMP levels and L-type calcium current amplitude, and abolishes the inotropic effect following acute beta-adrenergic receptor stimulation. | Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. | 12/14/2013 |
| Our results demonstrated that the PDE2A2 variant carrying point mutations is expressed in PMP cells and may affect cell cycle progression by modulating cyclin A expression. | Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells.
Morita H, Murata T, Shimizu K, Okumura K, Inui M, Tagawa T., Free PMC Article | 09/14/2013 |
| found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space | Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5).
Ückert S, Oelke M, Albrecht K, Breitmeier D, Kuczyk MA, Hedlund P. | 01/21/2012 |
| Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design | Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design.
Howard BL, Thompson PE, Manallack DT. | 01/21/2012 |
| the phosphodiesterase 2A isoform localized to mitochondria regulates respiration | A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
Acin-Perez R, Russwurm M, Günnewig K, Gertz M, Zoidl G, Ramos L, Buck J, Levin LR, Rassow J, Manfredi G, Steegborn C., Free PMC Article | 10/29/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPoor replication of candidate genes for major depressive disorder using genome-wide association data.
Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, van Veen T, Willemsen G, DeRijk RH, de Geus EJ, Hoogendijk WJ, Sullivan PF, Penninx BW, Boomsma DI, Snieder H, Nolen WA. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| report the X-ray crystal structures of a PDE protein that includes both catalytic and regulatory domains, namely, PDE2A containing the N-terminal GAF domains and the catalytic domain. | Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.
Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS., Free PMC Article | 01/21/2010 |
| Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. | Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.
Diebold I, Djordjevic T, Petry A, Hatzelmann A, Tenor H, Hess J, Görlach A. | 01/21/2010 |