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    MZB1 marginal zone B and B1 cell specific protein [ Homo sapiens (human) ]

    Gene ID: 51237, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis.

    MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis.
    Xu M, Feng Y, Xiang X, Liu L, Tang G.

    04/12/2024
    MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps.

    MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps.
    Huang Y, Xu Z, Holtappels G, Shen Y, Van Zele T, Wen W, Zhang L, Zhang N, Bachert C.

    02/7/2024
    Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis.

    Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis.
    Sunnetci-Akkoyunlu D, Guzeldemir-Akcakanat E, Alkan B, Gurel B, Balta-Uysal VM, Akgun E, Baykal AT, Olgac V.

    11/20/2023
    MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-kappaB signaling and promotes alveolar bone loss.

    MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-κB signaling and promotes alveolar bone loss.
    Li D, Zhu Y, Zhang L, Shi L, Deng L, Ding Z, Ai R, Zhang X, He Y.

    07/30/2022
    High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.

    High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.
    Sowa ST, Moilanen A, Biterova E, Saaranen MJ, Lehtiö L, Ruddock LW.

    05/8/2021
    Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma.

    Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma.
    Chanukuppa V, Paul D, Taunk K, Chatterjee T, Sharma S, Shirolkar A, Islam S, Santra MK, Rapole S.

    03/13/2021
    COL1A1 and MZB1 as the hub genes influenced the proliferation, invasion, migration and apoptosis of rectum adenocarcinoma cells by weighted correlation network analysis.

    COL1A1 and MZB1 as the hub genes influenced the proliferation, invasion, migration and apoptosis of rectum adenocarcinoma cells by weighted correlation network analysis.
    Wu W, Yang Z, Long F, Luo L, Deng Q, Wu J, Ouyang S, Tang D.

    03/6/2021
    Data suggest that marginal zone B and B1 cell specific protein (MZB1) may be a potential therapeutic target in excessive antibody-secreting cells in systemic lupus erythematosus (SLE).

    Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes.
    Miyagawa-Hayashino A, Yoshifuji H, Kitagori K, Ito S, Oku T, Hirayama Y, Salah A, Nakajima T, Kiso K, Yamada N, Haga H, Tsuruyama T., Free PMC Article

    04/13/2019
    expression was positively correlated with a high accumulation of CD8(+) tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy

    MZB1 in borderline resectable pancreatic cancer resected after neoadjuvant chemoradiotherapy.
    Miyake K, Mori R, Homma Y, Matsuyama R, Okayama A, Murakami T, Hirano H, Endo I.

    12/16/2017
    Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection.

    Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer.
    Kanda M, Tanaka C, Kobayashi D, Tanaka H, Shimizu D, Shibata M, Takami H, Hayashi M, Iwata N, Niwa Y, Yamada S, Fujii T, Nakayama G, Fujiwara M, Kodera Y.

    04/29/2017
    High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.

    High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.
    Herold T, Mulaw MA, Jurinovic V, Seiler T, Metzeler KH, Dufour A, Schneider S, Kakadia PM, Spiekermann K, Mansmann U, Hiddemann W, Buske C, Dreyling M, Bohlander SK.

    03/1/2014
    miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1.

    Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.
    Belkaya S, Murray SE, Eitson JL, de la Morena MT, Forman JA, van Oers NSC., Free PMC Article

    01/4/2014
    results suggested that MGC29506 has the potential of functioning as a novel suppressor gene in gastric cancer

    MGC29506 induces cell cycle arrest and is downregulated in gastric cancer.
    Xia L, Shen C, Fu Y, Tian L, Chen M.

    06/22/2013
    methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis

    Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma.
    Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J.

    10/27/2012
    Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer.

    [Proteomics-based identification of proapoptotic caspase adapter protein as a novel serum marker of non-small cell lung cancer].
    Zhang H, Chen S, Huang L., Free PMC Article

    09/29/2012
    MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506]

    MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues.
    Katoh M, Katoh M.

    01/21/2010
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