| Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells. | Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells.
Dai N, Ma H, Feng Y. | 10/10/2023 |
| CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis. | CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis.
Yu F, Xing J, Li L, Xiang M. | 07/7/2023 |
| Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT. | Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT.
Park Y, Kim H, Seo H, Choi JY, Ma Y, Yun S, Min BJ, Seo ME, Yoo KH, Kang HJ, Im HJ, Kim JH., Free PMC Article | 07/24/2021 |
| We propose here a series of intracellular events where CRIM1 regulation of the ERK pathway prevents UV-induced cell proliferation and may play an important role in the in the pathogenesis of pterygium. | A novel role for CRIM1 in the corneal response to UV and pterygium development.
Maurizi E, Schiroli D, Atkinson SD, Mairs L, Courtney DG, O'Hagan B, McGilligan VE, Pagnamenta AT, Taylor JC, Vasquez JJD, Illanes-Velarde DE, Goldsmith D, Gouws P, Moore JE, Nesbit MA, Moore CBT. | 04/20/2019 |
| CRIM1 regulates the expression of several epithelial-mesenchymal transition (EMT) related factors and appears to play a role in suppressing migration and invasion through control of EMT. | Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells.
Ogasawara N, Kudo T, Sato M, Kawasaki Y, Yonezawa S, Takahashi S, Miyagi Y, Natori Y, Sugiyama A. | 09/15/2018 |
| these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature. | CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.
Iyer S, Chhabra Y, Harvey TJ, Wang R, Chiu HS, Smith AG, Thomas WG, Pennisi DJ, Piper M. | 03/11/2017 |
| These observations provide evidence for the first time that CRIM1 plays a role in cancer cells by enhancing the migration and adhesion and increasing the expression of N-CAD and E-CAD. | CRIM1, a newfound cancer-related player, regulates the adhesion and migration of lung cancer cells.
Zeng H, Zhang Y, Yi Q, Wu Y, Wan R, Tang L. | 10/22/2016 |
| CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development. | CRIM1 haploinsufficiency causes defects in eye development in human and mouse.
Beleggia F, Li Y, Fan J, Elcioğlu NH, Toker E, Wieland T, Maumenee IH, Akarsu NA, Meitinger T, Strom TM, Lang R, Wollnik B., Free PMC Article | 02/6/2016 |
| Knock down of CRIM1 had no effect on VEGF-induced proliferation or migration of umbilical vein endothelial cells (HUVECs), indicating that basal CRIM1 is not involved in the proliferation or migration of endothelial cells. | Inhibition of the proliferation and acceleration of migration of vascular endothelial cells by increased cysteine-rich motor neuron 1.
Nakashima Y, Morimoto M, Toda K, Shinya T, Sato K, Takahashi S. | 08/22/2015 |
| Data suggest that CRIM1 plays role in cancer progression/metastasis, epithelial-mesenchymal transition, and neoplastic angiogenesis. [REVIEW] | CRIM1, the antagonist of BMPs, is a potential risk factor of cancer.
Zeng H, Tang L. | 06/20/2015 |
| BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF. | Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity.
Eleuteri E, Di Stefano A, Vallese D, Gnemmi I, Pitruzzella A, Tarro Genta F, Delle Donne L, Cappello F, Ricciardolo FL, Giannuzzi P. | 01/3/2015 |
| CRIM1 is an early response gene in the presence of both angiogenic stimulation (VEGF) and environmental (extracellular matrix) factors, and Erk and FAK might be involved in the upregulation of CRIM1 mRNA expression in vascular endothelial cells. | Induction of cysteine-rich motor neuron 1 mRNA expression in vascular endothelial cells.
Nakashima Y, Takahashi S. | 10/25/2014 |
| Study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance. | CRIM1 is expressed at higher levels in drug-resistant than in drug-sensitive myeloid leukemia HL60 cells.
Prenkert M, Uggla B, Tidefelt U, Strid H. | 12/11/2010 |
| CRIM1 has a role in capillary formation and maintenance during angiogenesis | CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.
Glienke J, Sturz A, Menrad A, Thierauch KH. | 11/16/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
Polasek O, Marusić A, Rotim K, Hayward C, Vitart V, Huffman J, Campbell S, Janković S, Boban M, Biloglav Z, Kolcić I, Krzelj V, Terzić J, Matec L, Tometić G, Nonković D, Nincević J, Pehlić M, Zedelj J, Velagić V, Juricić D, Kirac I, Belak Kovacević S, Wright AF, Campbell H, Rudan I., Free PMC Article | 03/25/2009 |
| CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface | CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.
Wilkinson L, Kolle G, Wen D, Piper M, Scott J, Little M. | 01/21/2010 |