| N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation. | N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.
Zhang Z, Wang L, Zhao L, Wang Q, Yang C, Zhang M, Wang B, Jiang K, Ye Y, Wang S, Shen Z., Free PMC Article | 08/27/2022 |
| PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4pSTAT3MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma. | PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.
Liu X, Zhang Z, Kan S, Lv Z, Zhou S, Liu X, Jing P, Xu W., Free PMC Article | 12/11/2021 |
| PHF20 interacts with poly(ADP-ribose) polymerase 1 (PARP1) and directly binds to promoter regions of octamer-binding transcription factor 4 (OCT4) and sex determining region Y-box 2 (SOX2) to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit (H3K4me3). | PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.
Long W, Zhao W, Ning B, Huang J, Chu J, Li L, Ma Q, Xing C, Wang HY, Liu Q, Wang RF., Free PMC Article | 09/7/2019 |
| These findings establish a unique PHF20-mediated link between MOF histone acetyltransferase (HAT), p53, and dimethylated lysine 4 of histone H3, and suggest a model for rapid spreading of H4K16ac-enriched open chromatin. | PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Klein BJ, Wang X, Cui G, Yuan C, Botuyan MV, Lin K, Lu Y, Wang X, Zhao Y, Bruns CJ, Mer G, Shi X, Kutateladze TG., Free PMC Article | 11/26/2017 |
| PHF20 may play an important role in Non-small-cell lung cancer (NSCLC). | Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.
Tang N, Ma L, Lin XY, Zhang Y, Yang DL, Wang EH, Qiu XS., Free PMC Article | 12/17/2016 |
| Along with the PHF20/MOF complex, G9a links the crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression. | G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.
Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X., Free PMC Article | 07/30/2016 |
| suggests a del(20q)-independent decrease in PHF20 expression in primary myelofibrosis | Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.
Lasho TL, Pardanani A, Tefferi A, Smith DI. | 10/11/2014 |
| Plant homeodomain finger protein 20 (PHF20) maintains NF-kappaB in an active state in the nucleus by inhibiting the interaction between PP2A and p65. | PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Zhang T, Park KA, Li Y, Byun HS, Jeon J, Lee Y, Hong JH, Kim JM, Huang SM, Choi SW, Kim SH, Sohn KC, Ro H, Lee JH, Lu T, Stark GR, Shen HM, Liu ZG, Park J, Hur GM., Free PMC Article | 01/4/2014 |
| PHF20 is a novel substrate for PKB and its phosphorylation by PKB plays an important role in tumorigenesis via regulating of p53 mediated signaling. | PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J. | 05/4/2013 |
| Association with PHF20 promotes stabilization and activation of p53 by diminishing Mdm2-mediated p53 ubiquitylation and degradation. | PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G., Free PMC Article | 11/17/2012 |
| Data report the crystal structures of the N-terminal Tudor domains of PHF20 and highlight the novel structural features of each domain. | Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.
Adams-Cioaba MA, Li Z, Tempel W, Guo Y, Bian C, Li Y, Lam R, Min J. | 06/16/2012 |
| genetic alterations of TSPAN14, SLC2A13 and PHF20 could play a role in non-small-cell lung cancer promotion | Identification of genes associated with non-small-cell lung cancer promotion and progression.
Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, Tanic N. | 04/12/2010 |
| GLEA2 seroreactivity was increased by the time of surgery, decreased after surgery, increased again under radiation, and slightly decreased after radiation | Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiation.
Heisel SM, Ketter R, Keller A, Klein V, Pallasch CP, Lenhof HP, Meese E., Free PMC Article | 01/21/2010 |
| Survival of patients with GLEA2 antibodies was increased to 17.4 months and for patients with PHF3 antibodies to 14.7 months, as compared to 7.2 months for patients without GLEA2 or PHF3 antibodies in glioblastoma. | Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival.
Pallasch CP, Struss AK, Munnia A, König J, Steudel WI, Fischer U, Meese E. | 01/21/2010 |