| NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation. | NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation.
Liu Y, Tang R, Meng QC, Shi S, Xu J, Yu XJ, Zhang B, Wang W., Free PMC Article | 01/29/2024 |
| NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression. | NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression.
Sun M, Wang Y, Xin G, Yang B, Jiang Q, Zhang C., Free PMC Article | 12/22/2023 |
| NUSAP1 regulates basal cell carcinoma migration, invasion and DNA damage through activation of the Hedgehog signaling pathway. | NUSAP1 regulates basal cell carcinoma migration, invasion and DNA damage through activation of the Hedgehog signaling pathway.
Zhu Y, Liu Y, Zhang L, Zeng S, Xu W. | 06/22/2023 |
| A recurrent de novo variant in NUSAP1 escapes nonsense-mediated decay and leads to microcephaly, epilepsy, and developmental delay. | A recurrent de novo variant in NUSAP1 escapes nonsense-mediated decay and leads to microcephaly, epilepsy, and developmental delay.
Mo A, Paz-Ebstein E, Yanovsky-Dagan S, Lai A, Mor-Shaked H, Gilboa T, Yang E, Shao DD, Walsh CA, Harel T., Free PMC Article | 06/13/2023 |
| NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer. | NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer.
Chiu CL, Li CG, Verschueren E, Wen RM, Zhang D, Gordon CA, Zhao H, Giaccia AJ, Brooks JD., Free PMC Article | 04/14/2023 |
| NUSAP1, a novel stemness-related protein, promotes early recurrence of hepatocellular carcinoma. | NUSAP1, a novel stemness-related protein, promotes early recurrence of hepatocellular carcinoma.
Li J, Tang M, Wu J, Qu H, Tu M, Pan Z, Gao C, Yang Y, Qu C, Huang W, Hong J., Free PMC Article | 12/24/2022 |
| Knockdown of NUSAP1 inhibits cell proliferation and invasion through downregulation of TOP2A in human glioblastoma. | Knockdown of NUSAP1 inhibits cell proliferation and invasion through downregulation of TOP2A in human glioblastoma.
Hu Y, Xue Z, Qiu C, Feng Z, Qi Q, Wang J, Jin W, Zhong Z, Liu X, Li W, Zhang Q, Huang B, Chen A, Wang J, Yang N, Zhou W., Free PMC Article | 08/13/2022 |
| Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer. | Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer.
Gou R, Zheng M, Hu Y, Gao L, Wang S, Liu O, Li X, Zhu L, Liu J, Lin B., Free PMC Article | 07/2/2022 |
| Evaluate the diagnostic and prognostic value of NUSAP1 in papillary thyroid carcinoma and identify the relationship with genes, proteins, and immune factors. | Evaluate the diagnostic and prognostic value of NUSAP1 in papillary thyroid carcinoma and identify the relationship with genes, proteins, and immune factors.
Gao T, Zhao L, Zhang F, Cao C, Fan S, Shi X., Free PMC Article | 06/25/2022 |
| Prognostic Value of NUSAP1 and Its Correlation with Immune Infiltrates in Human Breast Cancer. | Prognostic Value of NUSAP1 and Its Correlation with Immune Infiltrates in Human Breast Cancer.
Li M, Yang B. | 06/18/2022 |
| Increased NUSAP1 expression is associated with lymph node metastasis and survival prognosis in bladder urothelial carcinoma. | Increased NUSAP1 expression is associated with lymph node metastasis and survival prognosis in bladder urothelial carcinoma.
Hou J, Lu Z, Liu X, Luo B, Qu G, Xu Y, Tang C., Free PMC Article | 05/14/2022 |
| Nucleolar and spindleassociated protein 1 promotes nonsmall cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D. | Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
Ling B, Wei P, Xiao J, Cen B, Wei H, Feng X, Ye G, Li S, Zhang Z, Liang W, Huang S, Huang W., Free PMC Article | 10/23/2021 |
| NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR. | NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR.
Zhao Y, He J, Li Y, Lv S, Cui H., Free PMC Article | 10/16/2021 |
| The role of nucleolar spindle-associated protein 1 in human ovarian cancer. | The role of nucleolar spindle-associated protein 1 in human ovarian cancer.
Zhang Y, Huang K, Cai H, Chen S, Sun D, Jiang P. | 08/7/2021 |
| MCM2 and NUSAP1 Are Potential Biomarkers for the Diagnosis and Prognosis of Pancreatic Cancer. | MCM2 and NUSAP1 Are Potential Biomarkers for the Diagnosis and Prognosis of Pancreatic Cancer.
Deng Y, Ma H, Hao J, Xie Q, Zhao R., Free PMC Article | 02/13/2021 |
| NUSAP1 knockdown inhibits cell growth and metastasis of non-small-cell lung cancer through regulating BTG2/PI3K/Akt signaling. | NUSAP1 knockdown inhibits cell growth and metastasis of non-small-cell lung cancer through regulating BTG2/PI3K/Akt signaling.
Xu Z, Wang Y, Xiong J, Cui F, Wang L, Peng H. | 02/6/2021 |
| [NUSAP1 promotes lung cancer progression by activating AKT/mTOR signaling pathway]. | [NUSAP1 promotes lung cancer progression by activating AKT/mTOR signaling pathway].
Yu Z, Li XM, Huai M, Cao SS, Han HY, Bi YH. | 12/5/2020 |
| NuSAP1 is a carcinogen that facilitates progression of triple-negative breast cancer through the Wnt/beta-catenin and epithelial-mesenchymal transition pathways. | Overexpression of NuSAP1 is predictive of an unfavourable prognosis and promotes proliferation and invasion of triple-negative breast cancer cells via the Wnt/β-catenin/EMT signalling axis.
Sun L, Shi C, Liu S, Zhang E, Yan L, Ji C, Zhao Y. | 05/23/2020 |
| The inhibition of NUSAP1 by siRNAs induced resistance to Galiellalactone (GL)in DU145 cells, suggesting that NUSAP1 may be a target for GL and could be useful as a biomarker for the responsiveness of the antitumor activity of GL. | SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a potential molecular target for Galiellalactone.
Garrido-Rodríguez M, Ortea I, Calzado MA, Muñoz E, García V. | 05/9/2020 |
| Our results demonstrate thatNUSAP1 upregulation contributes to metastasis of cervical cancer by promoting CSC properties and EMT via Wnt/beta-catenin signaling and XAV-939 might serve as a potential tailored therapeutic option for patients with NUSAP1-ovexpressed cervical cancer. | Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling.
Li H, Zhang W, Yan M, Qiu J, Chen J, Sun X, Chen X, Song L, Zhang Y., Free PMC Article | 04/20/2019 |
| NUSAP1 silencing by siRNA inhibited colorectal cancer cell proliferation, and induces cell apoptosis. Moreover, NUSAP1 knockdown suppressed cell migration, cell invasion, and epithelial-to-mesenchymal transition. | NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer.
Han G, Wei Z, Cui H, Zhang W, Wei X, Lu Z, Bai X. | 03/9/2019 |
| Study provides evidence that downregulation of NUSAP1 can inhibit the proliferation, migration, and invasion of IBC cells by regulating CDK1 and DLGAP5 expression and enhances the drug susceptibility to E-ADM. | Nucleolar and Spindle Associated Protein 1 (NUSAP1) Inhibits Cell Proliferation and Enhances Susceptibility to Epirubicin In Invasive Breast Cancer Cells by Regulating Cyclin D Kinase (CDK1) and DLGAP5 Expression.
Zhang X, Pan Y, Fu H, Zhang J., Free PMC Article | 02/2/2019 |
| Study provides new insights and evidence that Nucleolar and spindle-associated protein (NUSAP1) over-expression was significantly correlated with progression and prognosis of glioblastoma multiforme. Furthermore, knockdown of NUSAP1 revealed its regulation on G2/M progression and cell proliferation (both in vitro and in vivo). | Prognostic value of NUSAP1 in progression and expansion of glioblastoma multiforme.
Qian Z, Li Y, Ma J, Xue Y, Xi Y, Hong L, Dai X, Zhang Y, Ji X, Chen Y, Sheng M, Sheng Y, Yang L, Liu J, Dai X, Shi J, Xie T, Dong J. | 01/26/2019 |
| Study suggests that NUSAP1 might be involved in glioma progression and can serve as a prognosis biomarker for glioma patients. NUSAP1 silencing suppresses malignant phenotypes of glioma cells, which offer a theoretical foundation for further investigation of NUSAP1 as a possible target with advantages for glioma treatment. | Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients.
Zhu T, Xie P, Gao YF, Huang MS, Li X, Zhang W, Zhou HH, Liu ZQ., Free PMC Article | 12/22/2018 |
| NUSAP1 is overexpressed in colon cancer and high expression of NUSAP1 acts as an independent predictive factor for poor prognosis in colon cancer | High NUSAP1 expression predicts poor prognosis in colon cancer.
Liu Z, Guan C, Lu C, Liu Y, Ni R, Xiao M, Bian Z. | 10/27/2018 |