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    ZDHHC2 zinc finger DHHC-type palmitoyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 51201, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.

    Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
    Zhou B, Yang W, Li W, He L, Lu L, Zhang L, Liu Z, Wang Y, Chao T, Huang R, Gu Y, Jia T, Liu Q, Tian S, Pierre P, Maeda T, Liang Y, Kong E., Free PMC Article

    06/26/2021
    Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.

    Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.
    Zhang H, Li X, Ma C, Wang K, Zhou J, Chen J, Wang Y, Shi Y., Free PMC Article

    05/1/2021
    These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of HCC.

    A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma.
    Peng C, Zhang Z, Wu J, Lv Z, Tang J, Xie H, Zhou L, Zheng S., Free PMC Article

    02/28/2015
    reduced ZDHHC2 expression is associated with lymph node metastasis and independently predicts an unfavorable prognosis in gastric adenocarcinoma patients

    Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma.
    Yan SM, Tang JJ, Huang CY, Xi SY, Huang MY, Liang JZ, Jiang YX, Li YH, Zhou ZW, Ernberg I, Wu QL, Du ZM., Free PMC Article

    08/31/2013
    DHHC2 localizes primarily to the endoplasmic reticulum and Golgi apparatus suggesting that it is involved in S-acylation of newly-synthesized or recycling Lck involved in T cell signalling.

    DHHC2 is a protein S-acyltransferase for Lck.
    Zeidman R, Buckland G, Cebecauer M, Eissmann P, Davis DM, Magee AI.

    02/25/2012
    The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain

    The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.
    Greaves J, Carmichael JA, Chamberlain LH., Free PMC Article

    10/1/2011
    Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.

    Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
    Jia L, Linder ME, Blumer KJ., Free PMC Article

    07/2/2011
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    DHHC2-mediated palmitoylation of CKAP4 has a role in opposing cancer-related cellular behaviors.

    Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling.
    Planey SL, Keay SK, Zhang CO, Zacharias DA., Free PMC Article

    01/21/2010
    DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151

    DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.
    Sharma C, Yang XH, Hemler ME., Free PMC Article

    01/21/2010
    Identification of CKAP4/p63 as a substrate of DHHC2, a putative tumor suppressor.

    Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method.
    Zhang J, Planey SL, Ceballos C, Stevens SM Jr, Keay SK, Zacharias DA., Free PMC Article

    01/21/2010
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