| Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages. | Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages.
Omer S, Li J, Yang CX, Harrison RE., Free PMC Article | 02/5/2024 |
| beta3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis. | β3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis.
Cao Z, Ge S, Xu Z, Ma YQ. | 11/22/2021 |
| Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. | Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis.
Tong H, Wei Z, Yin J, Zhang B, Zhang T, Deng C, Huang Y, Zhang N., Free PMC Article | 09/12/2020 |
| Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage. | Positive selection on NIN, a gene involved in neurogenesis, and primate brain evolution.
Montgomery SH, Mundy NI. | 12/5/2015 |
| Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics. | Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability.
Srivatsa S, Parthasarathy S, Molnár Z, Tarabykin V. | 06/20/2015 |
| JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it | JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein.
Jay J, Hammer A, Nestor-Kalinoski A, Diakonova M., Free PMC Article | 02/14/2015 |
| A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. | Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype.
Grosch M, Grüner B, Spranger S, Stütz AM, Rausch T, Korbel JO, Seelow D, Nürnberg P, Sticht H, Lausch E, Zabel B, Winterpacht A, Tagariello A. | 07/26/2014 |
| The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells | Differential expression of centrosome-associated proteins in human brain tumors: a possible role of hNinein isoform 6 in cell differentiation.
Loh JK, Lieu AS, Chou CH, Lin CC, Yang MC, Lin FY, Hong YR, Howng SL. | 11/16/2013 |
| The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera. | Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus.
Howng SL, Chou AK, Lin CC, Lin ZA, Wang CJ, Loh JK, Lieu AS, Yen JH, Lee CI, Hong YR. | 11/5/2011 |
| Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. | Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
Ibi M, Zou P, Inoko A, Shiromizu T, Matsuyama M, Hayashi Y, Enomoto M, Mori D, Hirotsune S, Kiyono T, Tsukita S, Goto H, Inagaki M. | 06/18/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ., Free PMC Article | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.
Couch FJ, Wang X, Bamlet WR, de Andrade M, Petersen GM, McWilliams RR, Couch FJ, Wang X, Bamlet WR, de Andrade M, Petersen GM, McWilliams RR., Free PMC Articles: PMC2805468, PMC2805468 | 04/7/2010 |
| Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk | Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.
Couch FJ, Wang X, Bamlet WR, de Andrade M, Petersen GM, McWilliams RR, Couch FJ, Wang X, Bamlet WR, de Andrade M, Petersen GM, McWilliams RR., Free PMC Articles: PMC2805468, PMC2805468 | 03/15/2010 |
| Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. | Ninein is released from the centrosome and moves bi-directionally along microtubules.
Moss DK, Bellett G, Carter JM, Liovic M, Keynton J, Prescott AR, Lane EB, Mogensen MM. | 01/21/2010 |
| Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. | CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation.
Ou YY, Mack GJ, Zhang M, Rattner JB. | 01/21/2010 |
| Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation. | Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation.
Stillwell EE, Zhou J, Joshi HC. | 01/21/2010 |
| Overexpression of ninein and the ninein-like protein NIP induces fragmentation of the Golgi and causes lysosomes to disperse toward the cell periphery. | Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.
Casenghi M, Barr FA, Nigg EA. | 01/21/2010 |
| ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle | Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle.
Chen CH, Howng SL, Cheng TS, Chou MH, Huang CY, Hong YR. | 01/21/2010 |
| We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. | Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function.
Delgehyr N, Sillibourne J, Bornens M. | 01/21/2010 |
| hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity. | hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases.
Cheng TS, Hsiao YL, Lin CC, Hsu CM, Chang MS, Lee CI, Yu RC, Huang CY, Howng SL, Hong YR. | 01/21/2010 |
| analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin | Characterization and functional aspects of human ninein isoforms that regulated by centrosomal targeting signals and evidence for docking sites to direct gamma-tubulin.
Lin CC, Cheng TS, Hsu CM, Wu CH, Chang LS, Shen ZS, Yeh HM, Chang LK, Howng SL, Hong YR. | 01/21/2010 |
| our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus | SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization.
Cheng TS, Chang LK, Howng SL, Lu PJ, Lee CI, Hong YR. | 01/21/2010 |