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    CKLF chemokine like factor [ Homo sapiens (human) ]

    Gene ID: 51192, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.

    CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.
    Qin X, Lam A, Zhang X, Sengupta S, Iorgulescu JB, Ni H, Das S, Rager M, Zhou Z, Zuo T, Meara GK, Floru AE, Kemet C, Veerapaneni D, Kashy D, Lin L, Lloyd K, Kwok L, Smith KS, Nagaraju RT, Meijers R, Ceol C, Liu CT, Alexandrescu S, Wu CJ, Keskin DB, George RE, Feng H., Free PMC Article

    03/20/2024
    Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors.

    Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors.
    Duan SL, Jiang Y, Li GQ, Fu W, Song Z, Li LN, Li J., Free PMC Article

    02/15/2024
    Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke.

    Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke.
    Zhou X, Zhang YN, Li FF, Zhang Z, Cui LY, He HY, Yan X, He WB, Sun HS, Feng ZP, Chu SF, Chen NH., Free PMC Article

    05/14/2022
    Chemokine-like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF-kappaB /VCAM-1 pathway.

    Chemokine-like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF-κB /VCAM-1 pathway.
    Liu X, Qu C, Zhang Y, Fang J, Teng L, Zhang R, Zhang X, Shen C., Free PMC Article

    11/6/2021
    CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.

    CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.
    Fitter S, Bradey AL, Kok CH, Noll JE, Wilczek VJ, Venn NC, Law T, Paisitkriangkrai S, Story C, Saunders L, Dalla Pozza L, Marshall GM, White DL, Sutton R, Zannettino ACW, Revesz T.

    07/31/2021
    Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-kappaB pathway and regulating transporter mediated drug efflux.

    Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux.
    Chen C, Ai QD, Wei YH.

    03/6/2021
    Data indicate that leukocyte-infiltrate derived chemokine-like factor (CKLF) expression is a candidate biomarker of favorable prognosis.

    Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.
    Dunne PD, O'Reilly PG, Coleman HG, Gray RT, Longley DB, Johnston PG, Salto-Tellez M, Lawler M, McArt DG., Free PMC Article

    12/30/2017
    CKLF1 expression was up-regulated in synovim from rheumatoid arthritis and ankylosing spondylitis patients.

    Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
    Tao K, Tang X, Wang B, Li RJ, Zhang BQ, Lin JH, Li H.

    12/31/2016
    expression elevated in the skin of keloid patients

    Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential Indicating Factor for Keloid-Predisposed Individuals.
    Zhang M, Xu Y, Liu Y, Cheng Y, Zhao P, Liu H, Wang Y, Ma X., Free PMC Article

    08/6/2016
    role in the pathogenesis of psoriasis by promoting the proliferation of microvascular endothelial cells

    Chemokine-like factor 1-derived C-terminal peptides induce the proliferation of dermal microvascular endothelial cells in psoriasis.
    Tan Y, Wang Y, Li L, Xia J, Peng S, He Y., Free PMC Article

    04/23/2016
    Chemokine-like factor 1 is over-expressed in patients with atopic dermatitis.

    Chemokine-like factor 1 (CLFK1) is over-expressed in patients with atopic dermatitis.
    Yang GY, Chen X, Sun YC, Ma CL, Qian G., Free PMC Article

    03/29/2014
    CKLF1 can induce proliferation and inhibit apoptosis of human vascular smooth muscle cell through the down-regulation of Bax and Caspase-3 and the up-regulation of Bcl-2 expression.

    [Effects of chemokine-like factor 1 on the proliferation and apoptosis of human vascular smooth muscle cell].
    Zhang T, Xiong J, Shen CY, Jia SH, Liu J, Guo W.

    09/7/2013
    The expression of CKLF1 is up-regulated in atherosclerotic plaques.

    [The expression of chemokine-like factor 1 in human atherosclerotic plaques].
    Jiao Y, Shen CY, Zhang XM.

    07/9/2011
    CKLF1-C19 and -C27 can stimulate antigen-presenting capability of dendritic cells

    Expressional and functional studies of CKLF1 during dendritic cell maturation.
    Shao L, Li T, Mo X, Majdic O, Zhang Y, Seyerl M, Schrauf C, Ma D, Stöckl J, Han W.

    07/5/2010
    Observational study of gene-disease association. (HuGE Navigator)

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    04/7/2010
    Chemokine-like factor expression is differentially regulated in myoblasts and myotubes and thrombin could be a strong regulator for its expression

    Chemokine-like factor expression in the idiopathic inflammatory myopathies.
    Chowdhury MH, Nagai A, Terashima M, Sheikh A, Murakawa Y, Kobayashi S, Yamaguchi S.

    01/21/2010
    Results confirm that the secreted peptides of CKLF1, C27 and C19, have functional activation via CCR4.

    Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4.
    Wang Y, Zhang Y, Han W, Li D, Tian L, Yin C, Ma D.

    01/21/2010
    CKLF1 could increase the proliferation of human bone marrow hematopoietic progenitor cells and colony formation

    Effects of novel human chemokine-like factor 1 (CKLF1) on bone marrow hematopoietic stem cell/progenitor cell in vitro.
    Ke X, Jia L, Jing H, Liu Y, Zhang Y, Di C.

    01/21/2010
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