| CKIP-1 silencing suppresses OSCC via mitochondrial homeostasis-associated TFAM/cGAS-STING signalling axis. | CKIP-1 silencing suppresses OSCC via mitochondrial homeostasis-associated TFAM/cGAS-STING signalling axis.
Xie JR, Chen XJ, Zhou G., Free PMC Article | 10/2/2024 |
| Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults. | Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults.
Xiong J, Zhang L, Chen G, Dong P, Tong J, Hua L, Li N, Wen L, Zhu L, Chang W, Jin Y. | 02/29/2024 |
| CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy. | CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.
Xiao J, Huang X, Wang H, Peng Y, Liu H, Huang H, Ma L, Wang C, Wang X, Cao Z. | 10/24/2023 |
| [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease]. | [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
Li L, Xie P, Bi CS, Wang TY, Wang N, Lin WW, Zhang C, An W, Zhan YT. | 02/10/2023 |
| High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer. | High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer.
Ma L, Cao Y, Hu J, Chu M., Free PMC Article | 01/9/2021 |
| CKIP-1 could interact with Neuropilin-1 (NRP1). | CKIP-1 suppresses odontoblastic differentiation of dental pulp stem cells via BMP2 pathway and can interact with NRP1.
Song Y, Wang C, Gu Z, Cao P, Huang D, Feng G, Lian M, Zhang Y, Feng X, Gao Z. | 07/4/2020 |
| The molecular functions of CKIP-1 in cell morphology, cell differentiation and cell apoptosis, the involved biological processes including bone formation, tumorigenesis and immune regulation are REVIEWED. The potential role of CKIP-1 in the treatment of human diseases such as osteoporosis, tumor, and atherosclerosis is indicated. | Physiological functions of CKIP-1: From molecular mechanisms to therapy implications.
Fu L, Zhang L. | 04/18/2020 |
| mechanistic investigations suggested that CKIP-1 sharply suppressed the activity of AKT by inhibiting the phosphorylation, markedly downregulated the phosphorylated GSK3beta at Ser9, and promoted beta-catenin degradation. | Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3β/β-Catenin Pathway.
Xi YG, Ren DP, Jin JY, Zhu L, Yi TL, Shao XF, Sun SK, Zhang WB, Cheng SX., Free PMC Article | 01/4/2020 |
| The results showed that PLEKHO1 knockdown significantly inhibited cell viability and facilitated apoptosis in vitro and impaired tumour formation in vivo. | PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways.
Yu Z, Li Q, Zhang G, Lv C, Dong Q, Fu C, Kong C, Zeng Y., Free PMC Article | 10/5/2019 |
| we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations. | Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
Li MP, Zhang YJ, Hu XL, Zhou JP, Yang YL, Peng LM, Qi H, Yang TL, Chen XP., Free PMC Article | 03/31/2018 |
| we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation. | A novel role of CKIP-1 in promoting megakaryocytic differentiation.
Fan J, Wang Y, Shen Y, Liu Q, Gao R, Qiu Y, Wang C, Zhang L., Free PMC Article | 03/10/2018 |
| these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization. | Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
Chen Y, Liu W, Wang Y, Zhang L, Wei J, Zhang X, He F, Zhang L. | 12/2/2017 |
| the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. | Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.
Liu J, Liang C, Guo B, Wu X, Li D, Zhang Z, Zheng K, Dang L, He X, Lu C, Peng S, Pan X, Zhang BT, Lu A, Zhang G., Free PMC Article | 06/24/2017 |
| High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis. | Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299.
Chen GM, Ding RF, Tan YD, Pan XB, Jiang GM, He JF, Lin SH, Liu C, Jia Y. | 04/22/2017 |
| New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL. | Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.
Zhu X, Ouyang Y, Zhong F, Wang Q, Ding L, Zhang P, Chen L, Liu H, He S. | 04/8/2017 |
| There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation. | The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1).
Kim YB, Shin YJ, Roy A, Kim JH., Free PMC Article | 11/21/2015 |
| CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling. | CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1.
Sakamoto T, Kobayashi M, Tada K, Shinohara M, Io K, Nagata K, Iwai F, Takiuchi Y, Arai Y, Yamashita K, Shindo K, Kadowaki N, Koyanagi Y, Takaori-Kondo A., Free PMC Article | 09/20/2014 |
| CKIP-1 controlled Smurf1 expression in colon cancer | CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Nie J, Liu L, Xing G, Zhang M, Wei R, Guo M, Li X, Xie P, Li L, He F, Han W, Zhang L. | 09/6/2014 |
| overexpression triggers classical monocyte activation and transactivation of the TNF promoter | Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells.
Juhász K, Zvara A, Lipp AM, Nimmervoll B, Sonnleitner A, Balogi Z, Duda E. | 01/11/2014 |
| CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1-Rpt6 interaction. | CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation.
Wang Y, Nie J, Wang Y, Zhang L, Lu K, Xing G, Xie P, He F, Zhang L., Free PMC Article | 08/3/2013 |
| CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW | CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions.
Nie J, Liu L, He F, Fu X, Han W, Zhang L. | 06/29/2013 |
| The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling. | N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its nucleus-plasma membrane shuttling.
Xi S, Tie Y, Lu K, Zhang M, Yin X, Chen J, Xing G, Tian C, Zheng X, He F, Zhang L. | 05/3/2010 |
| Results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function. | Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T. | 01/21/2010 |
| CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein | The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.
Canton DA, Olsten ME, Niederstrasser H, Cooper JA, Litchfield DW., Free PMC Article | 01/21/2010 |
| CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein. | The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein.
Canton DA, Olsten ME, Kim K, Doherty-Kirby A, Lajoie G, Cooper JA, Litchfield DW., Free PMC Article | 01/21/2010 |