| Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2). | Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).
Cui Z, Sun S, Li J, Li J, Sha T, He J, Zuo L. | 09/17/2022 |
| ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer. | ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer.
Shatnawi A, Ayoub NM, Alkhalifa AE. | 01/22/2022 |
| ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions. | ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
Martinez-Vargas YDC, Silva-Filho TJD, Oliveira DHIP, Gonçalo RIC, Queiroz LMG. | 12/18/2021 |
| [Expression levels of MMP-14, ING4 and HIF-1alpha in 60 patients with oral squamous cell carcinoma and their clinical significance]. | [Expression levels of MMP-14, ING4 and HIF-1α in 60 patients with oral squamous cell carcinoma and their clinical significance].
Fu ZY, Tao F. | 04/3/2021 |
| Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark. | Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark.
Palacios A, Blanco FJ., Free PMC Article | 03/20/2021 |
| Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis. | Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis.
Trinh DA, Shirakawa R, Kimura T, Sakata N, Goto K, Horiuchi H., Free PMC Article | 11/21/2020 |
| Low ING4 expression is associated with cell proliferation and migration of renal cell carcinoma . | Inhibitor of growth 4 inhibits cell proliferation, migration, and induces apoptosis of renal cell carcinoma cells.
Sun J, Xie L, Lv J, Zhang W, Lv J, Liang Y, Geng Y, Li X. | 07/11/2020 |
| Found antibodies binding to p29ING4. | Autoantibodies against P29ING4 are associated with complex regional pain syndrome.
Baerlecken NT, Gaulke R, Pursche N, Witte T, Karst M, Bernateck M. | 05/30/2020 |
| differential expression profile revealed the potential role of ING4 in prostate cancer pathogenesis possibly through modulation of key genes, pathways and biological networks that are central drivers of the disease. | Identification of the inhibitor of growth protein 4 (ING4) as a potential target in prostate cancer therapy.
Shatnawi A, Malkaram SA, Fandy T, Tsouko E. | 03/21/2020 |
| These findings suggest that ING4 may inhibit hypoxia-induced EMT via decreasing HIF-1alpha and snail in HK2 cells, indicating the potential of ING4 as a therapeutic target for renal fibrosis. | Inhibitor of growth 4 (ING4) inhibits hypoxia-induced EMT by decreasing HIF-1α and snail in HK2 cells.
Lu L, Li J, Le Y, Jiang H. | 12/28/2019 |
| We also present the current understanding concerning the role of ING4 in the development of neoplastic and non-neoplastic diseases. These studies offer inspiration for pursuing novel therapeutics for various cancers. | The essential role of tumor suppressor gene ING4 in various human cancers and non-neoplastic disorders.
Du Y, Cheng Y, Su G., Free PMC Article | 07/27/2019 |
| Splicing type of ING4 affects the translocation of ING4 proteins into the nucleus. | Gene expression of ING4 gene in pancreatic cancers and splice forms of ING4 gene.
Yıldırım İH, Çakmak EA, Camcı C. | 12/22/2018 |
| Both CELSR2 and ING4 display increased cytoplasmic staining in breast cancer cells compared to benign epithelium, suggesting a possible role of both genes in the pathogenesis of human mammary neoplasia. | Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer.
Jiang L, Zhang X, Xiang C, Geradts J, Wei Q, Liang Y, Huang H, Xu JF. | 12/1/2018 |
| These results demonstrated that overexpression of ING4 can induce the apoptosis of melanoma cells and CD3+ T cells through signaling pathways such as the Fas/FasL pathway, and that ING4 gene therapy for melanoma treatment is a novel approach. | Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway.
Cai L, Li H, Chen C, Cheng X, Wang Y, Liu J, Wang Y, Hao L. | 07/21/2018 |
| Inhibitor of growth 4 upregulation plus radiotherapy induced synergistic tumor suppression in SPC-A1 xenografts implanted in athymic nude mice. Thus, the restoration of inhibitor of growth 4 function might provide a potential strategy for non-small cell lung cancer radiosensitization. | Overexpression of Inhibitor of Growth 4 Enhances Radiosensitivity in Non-Small Cell Lung Cancer Cell Line SPC-A1.
Pan X, Wang R, Bian H, De W, Zhang P, Wei C, Wang Z., Free PMC Article | 05/5/2018 |
| Results found that ING4 expression was significantly reduced in CRC tissues and associated with increased lymph node metastasis, advanced TNM stage and poor overall survival. Also, ING4 suppressed CRC angiogenesis by inhibition of Sp1 expression and transcriptional activity through destabilization and ubiquitin degradation and down-regulation of Sp1 downstream pro-angiogenic factors MMP-2 and COX-2. | ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer.
Chen Y, Huang Y, Hou P, Zhang Z, Zhang Y, Wang W, Sun G, Xu L, Zhou J, Bai J, Zheng J., Free PMC Article | 02/17/2018 |
| Low ING4 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas. | miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas.
Li S, Zeng A, Hu Q, Yan W, Liu Y, You Y., Free PMC Article | 10/7/2017 |
| ING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation. | Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.
Berger PL, Winn ME, Miranti CK., Free PMC Article | 08/12/2017 |
| The oncogenic role of miR-330 in Hepatocellular Carcinoma Cells is linked to downregulation of ING4. | Roles of microRNA-330 and Its Target Gene ING4 in the Development of Aggressive Phenotype in Hepatocellular Carcinoma Cells.
Hu X, Feng Y, Sun L, Qu L, Sun C. | 07/15/2017 |
| ING4 binds double-stranded DNA through its central region with micromolar affinity. | The tumor suppressor inhibitor of growth 4 binds double-stranded DNA through its disordered central region.
Ormaza G, Medagli B, Ibáñez de Opakua A, Rodríguez JA, Merino N, Villate M, Onesti S, Blanco FJ. | 05/13/2017 |
| results indicate that the combination of ING4 and PTEN may provide an effective therapeutic strategy for HCC | Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells.
Rakshit N, Yang S, Zhou W, Xu Y, Deng C, Yang J, Yu H, Wei W. | 02/18/2017 |
| ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed | Inhibitor of growth-4 is a potential target for cancer therapy.
Yuan S, Jin J, Shi J, Hou Y. | 02/4/2017 |
| ING4 inhibits CRC invasion and metastasis probably via a switch from mesenchymal marker N-cadherin to epithelial marker E-cadherin through downregulation of Snail1 epithelial-mesenchymal transition (EMT)-inducing transcription factor (EMT-TF). | Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition.
Qu H, Yin H, Yan S, Tao M, Xie Y, Chen W. | 12/31/2016 |
| Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG)-Fas protein axis to promote apoptosis resistance in pancreatic cancer. | Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.
Sun J, Shen Q, Lu H, Jiang Z, Xu W, Feng L, Li L, Wang X, Cai X, Jin H., Free PMC Article | 10/1/2016 |
| MiR-761 directly targeted ING4 and TIMP2. | MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2.
Yan A, Yang C, Chen Z, Li C, Cai L. | 05/28/2016 |