| Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions. | Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.
Kumari A, Kumar C, Pergu R, Kumar M, Mahale SP, Wasnik N, Mylavarapu SVS., Free PMC Article | 12/25/2021 |
| Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes. | Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.
Sakthikumar S, Roy A, Haseeb L, Pettersson ME, Sundström E, Marinescu VD, Lindblad-Toh K, Forsberg-Nilsson K., Free PMC Article | 04/3/2021 |
| Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer. | Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Chang CC, Chao KC, Huang CJ, Hung CS, Wang YC., Free PMC Article | 02/13/2021 |
| High DLIC1 expression is associated with colon cancer | DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells.
Even I, Reidenbach S, Schlechter T, Berns N, Herold R, Roth W, Krunic D, Riechmann V, Hofmann I. | 11/9/2019 |
| conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility | A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity.
Lee IG, Olenick MA, Boczkowska M, Franzini-Armstrong C, Holzbaur ELF, Dominguez R., Free PMC Article | 12/22/2018 |
| the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. | Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.
Liu ZD, Zhang S, Hao JJ, Xie TR, Kang JS., Free PMC Article | 06/10/2017 |
| This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. | Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
Schroeder CM, Vale RD., Free PMC Article | 06/3/2017 |
| although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. | Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.
Jones LA, Villemant C, Starborg T, Salter A, Goddard G, Ruane P, Woodman PG, Papalopulu N, Woolner S, Allan VJ., Free PMC Article | 03/21/2015 |
| using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. | Recruitment of dynein to late endosomes and lysosomes through light intermediate chains.
Tan SC, Scherer J, Vallee RB., Free PMC Article | 05/28/2011 |
| Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. | Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment.
Horgan CP, Hanscom SR, Jolly RS, Futter CE, McCaffrey MW. | 03/8/2010 |
| Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint | Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.
Sivaram MV, Wadzinski TL, Redick SD, Manna T, Doxsey SJ., Free PMC Article | 01/21/2010 |