| FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression of renal cell carcinoma through AMPK/mTOR pathway. | FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression of renal cell carcinoma through AMPK/mTOR pathway.
Li J, Chen S, Xiao J, Ji J, Huang C, Shu G., Free PMC Article | 09/11/2024 |
| ABHD5-CPT1B: An Important Way of Regulating Placental Lipid Metabolism in Gestational Diabetes Mellitus. | ABHD5-CPT1B: An Important Way of Regulating Placental Lipid Metabolism in Gestational Diabetes Mellitus.
Yang Y, Peng Y, Yu B, Wang H. | 02/6/2024 |
| ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation. | ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation.
Gu Y, Chen Y, Wei L, Wu S, Shen K, Liu C, Dong Y, Zhao Y, Zhang Y, Zhang C, Zheng W, He J, Wang Y, Li Y, Zhao X, Wang H, Tan J, Wang L, Zhou Q, Xie G, Liang H, Ou J., Free PMC Article | 01/1/2022 |
| Two cases of non-alcoholic fatty liver disease caused by biallelic ABHD5 mutations. | Two cases of non-alcoholic fatty liver disease caused by biallelic ABHD5 mutations.
Adant I, Declercq M, Bird M, Bauters M, Boeckx N, Devriendt K, Cassiman D, Witters P. | 12/25/2021 |
| circFAM120A participates in repeated implantation failure by regulating decidualization via the miR-29/ABHD5 axis. | circFAM120A participates in repeated implantation failure by regulating decidualization via the miR-29/ABHD5 axis.
Zhou T, Ni T, Li Y, Zhang Q, Yan J, Chen ZJ. | 10/16/2021 |
| Two cases of Chanarin-Dorfman syndrome with novel and recurrent mutations in the ABHD5 gene. | Two cases of Chanarin-Dorfman syndrome with novel and recurrent mutations in the ABHD5 gene.
Jiang X, Zhong W, Yu B, Lin Z, Wang H. | 06/26/2021 |
| The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. | The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4.
Jebessa ZH, Shanmukha KD, Dewenter M, Lehmann LH, Xu C, Schreiter F, Siede D, Gong XM, Worst BC, Federico G, Sauer SW, Fischer T, Wechselberger L, Müller OJ, Sossalla S, Dieterich C, Most P, Gröne HJ, Moro C, Oberer M, Haemmerle G, Katus HA, Tyedmers J, Backs J., Free PMC Article | 01/23/2021 |
| Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes. | Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes.
Yang A, Mottillo EP, Mladenovic-Lucas L, Zhou L, Granneman JG., Free PMC Article | 01/9/2021 |
| CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis. | CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis.
Yu L, Li Y, Grisé A, Wang H., Free PMC Article | 01/2/2021 |
| Downregulated ABHD5 Aggravates Insulin Resistance of Trophoblast Cells During Gestational Diabetes Mellitus. | Downregulated ABHD5 Aggravates Insulin Resistance of Trophoblast Cells During Gestational Diabetes Mellitus.
Peng HY, Li HP, Li MQ. | 12/12/2020 |
| Inherited non-alcoholic fatty liver disease and dyslipidemia due to monoallelic ABHD5 mutations. | Inherited non-alcoholic fatty liver disease and dyslipidemia due to monoallelic ABHD5 mutations.
Youssefian L, Vahidnezhad H, Saeidian AH, Pajouhanfar S, Sotoudeh S, Mansouri P, Amirkashani D, Zeinali S, Levine MA, Peris K, Colombo R, Uitto J., Free PMC Article | 11/28/2020 |
| The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. | The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly.
Vieyres G, Reichert I, Carpentier A, Vondran FWR, Pietschmann T., Free PMC Article | 08/15/2020 |
| Reduced expression of the metabolic enzyme ABHD5 in macrophages promotes cancer metastasis. | Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis.
Shang S, Ji X, Zhang L, Chen J, Li C, Shi R, Xiang W, Kang X, Zhang D, Yang F, Dai R, Chen P, Chen S, Chen Y, Li Y, Miao H. | 05/30/2020 |
| ABHD5 is a potential therapeutic target against metastatic castration-resistant prostate cancer. | Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.
Chen G, Zhou G, Aras S, He Z, Lucas S, Podgorski I, Skar W, Granneman JG, Wang J., Free PMC Article | 06/29/2019 |
| The results here report on three patients with mutations in the ichthyosis-related gene, ABHD5 involved in lipid metabolism, presenting with erythrokeratoderma. | Erythrokeratoderma: a manifestation associated with multiple types of ichthyoses with different gene defects.
Youssefian L, Touati A, Vahidnezhad H, Saeidian AH, Sotoudeh S, Zeinali S, Uitto J. | 06/15/2019 |
| Study report that although ABHD5 plays a tumor suppressor role in colorectal cancer (CRC) development and progression, it unexpectedly blunts the sensitivity of CRC cells to fluorouracil via promoting RNASET2-mediated autophagic uracil yield. | ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.
Ou J, Peng Y, Yang W, Zhang Y, Hao J, Li F, Chen Y, Zhao Y, Xie X, Wu S, Zha L, Luo X, Xie G, Wang L, Sun W, Zhou Q, Li J, Liang H., Free PMC Article | 04/13/2019 |
| ABHD5 mutation is associated with Chanarin Dorfman Syndrome. | Clinical and genetic characterization of a Chanarin Dorfman Syndrome patient born to diseased parents.
Durdu M, Missaglia S, Moro L, Tavian D., Free PMC Article | 02/23/2019 |
| Study results suggest that ABHD5 functions to retain triglyceride, the substrate of PNPLA1, in the endoplasmic reticulum, the site of acylceramide production, and to present TG to PNPLA1. These findings reveal the molecular mechanism by which ABHD5 mutations cause ichthyosis symptoms in Chanarin-Dorfman syndrome. | Molecular mechanism of the ichthyosis pathology of Chanarin-Dorfman syndrome: Stimulation of PNPLA1-catalyzed ω-O-acylceramide production by ABHD5.
Ohno Y, Nara A, Nakamichi S, Kihara A. | 02/23/2019 |
| novel homozygote deletion in exon 4 of ABHD5 causing Chanarin-Dorfman syndrome (CDS), a rare autosomal recessive metabolic disorder. | A New Case of Chanarin-Dorfman Syndrome with a Novel Deletion in ABHD5 Gene.
Nakhaei S, Heidary H, Rahimian A, Vafadar M, Rohani F, Bahoosh GR, Amirkashani D., Free PMC Article | 01/19/2019 |
| our findings indicate that inhibition of both DGAT1 and ABHD5 using siRNA leads to reduction in prostate cancer cell growth. | Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5.
Mitra R, Le TT, Gorjala P, Goodman OB Jr., Free PMC Article | 05/12/2018 |
| Prebinding CGI-58 with PI(3)P or PI(5)P did not alter its coactivation of ATGL in vitro. In summary, purified recombinant CGI-58 that is functional as an ATGL coactivator lacks LPAAT activity. | Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity.
McMahon D, Dinh A, Kurz D, Shah D, Han GS, Carman GM, Brasaemle DL., Free PMC Article | 01/13/2018 |
| It is clear that CGI-58 can regulate TAG hydrolysis by activating the major TAG hydrolase adipose triglyceride lipase (ATGL), yet CGI-58 can also regulate lipid metabolism via mechanisms that do not involve ATGL. | Critical roles for α/β hydrolase domain 5 (ABHD5)/comparative gene identification-58 (CGI-58) at the lipid droplet interface and beyond.
Brown AL, Mark Brown J., Free PMC Article | 11/25/2017 |
| ABHD5 possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis. | ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2.
Peng Y, Miao H, Wu S, Yang W, Zhang Y, Xie G, Xie X, Li J, Shi C, Ye L, Sun W, Wang L, Liang H, Ou J., Free PMC Article | 11/18/2017 |
| These results indicate that HCV taps into the lipid droplet triglyceride reservoir usurping ABHD5 lipase cofactor function | ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production.
Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FW, Kaderali L, Pietschmann T., Free PMC Article | 06/3/2017 |
| Case Report: novel ABHD5 mutation, c.838C > T (p.Arg280*), in trans with p.Arg234* in a Chinese patient with very mild Dorfman-Chanarin syndrome. | Bi-allelic nonsense mutations inABHD5 underlie a mild phenotype of Dorfman-Chanarin syndrome.
Takeichi T, Sugiura K, Tso S, Simpson MA, McGrath JA, Akiyama M. | 12/17/2016 |