| ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway. | ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway.
Wang M, Wang T, Wang J, Yang Y, Li X, Chen H, Liao J., Free PMC Article | 09/13/2024 |
| A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer. | A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer.
Cui K, Yao S, Liu B, Sun S, Gong L, Li Q, Fei B, Huang Z., Free PMC Article | 10/15/2022 |
| Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis. | Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis.
Xu HM, Xu J, Yang MF, Liang YJ, Peng QZ, Zhang Y, Tian CM, Nie YQ, Wang LS, Yao J, Li DF., Free PMC Article | 07/2/2022 |
| ThPOK transcriptionally inactivates TNFRSF12A to increase the proliferation of T cells with the involvement of the NF-kB pathway. | ThPOK transcriptionally inactivates TNFRSF12A to increase the proliferation of T cells with the involvement of the NF-kB pathway.
Xia L, Jiang L, Chen Y, Zhang G, Chen L. | 02/19/2022 |
| Zbtb7a and Zbtb7b: Opening naive loci to reprogram ESCs. | Zbtb7a and Zbtb7b: Opening naïve loci to reprogram ESCs.
Cao H, Huang H, Tang H. | 11/13/2021 |
| Zbtb7b suppresses aseptic inflammation by regulating m(6)A modification of IL6 mRNA. | Zbtb7b suppresses aseptic inflammation by regulating m(6)A modification of IL6 mRNA.
Zhao J, Han DX, Wang CB, Wang XL. | 02/27/2021 |
| Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. | Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.
Srivastava A, Mishra RK. | 11/21/2020 |
| In vitro, prolonged activation of naive CD4 T cells in presence of Th1 polarizing cytokines led to the acquisition of perforin-dependent cytotoxic activity. This process was dependent on the Th1 transcription factor Runx3 and was limited by the sustained expression of ThPOK. | The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes.
Serroukh Y, Gu-Trantien C, Hooshiar Kashani B, Defrance M, Vu Manh TP, Azouz A, Detavernier A, Hoyois A, Das J, Bizet M, Pollet E, Tabbuso T, Calonne E, van Gisbergen K, Dalod M, Fuks F, Goriely S, Marchant A., Free PMC Article | 07/13/2019 |
| Authors show that the transcription factor ThPOK binds cooperatively with NF-kappaB to NRCs and mediates their physical proximity with the IFNB1 gene via its ability to oligomerize when bound to DNA. | The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.
Nikopoulou C, Panagopoulos G, Sianidis G, Psarra E, Ford E, Thanos D. | 03/30/2019 |
| a novel pathway by which TIP60 and ThPOK synergistically suppresses Eomes function and IFNgamma production, which could contribute to the regulation of inflammation. | 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells.
Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B., Free PMC Article | 08/10/2013 |
| ThPOK may be considered a central regulator of the earliest events in the immune system during colorectal cancer development, decreasing the immune response against cancer cells. | Th inducing POZ-Kruppel Factor (ThPOK) is a key regulator of the immune response since the early steps of colorectal carcinogenesis.
Mariani F, Sena P, Pedroni M, Benatti P, Manni P, Di Gregorio C, Manenti A, Palumbo C, de Leon MP, Roncucci L., Free PMC Article | 07/20/2013 |
| The distal regulatory element (DRE) in the Thpok gene also functions as a transcriptional enhancer, with DNA sequences specifically responsible for thymic enhancer activity. | Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.
Muroi S, Tanaka H, Miyamoto C, Taniuchi I., Free PMC Article | 03/30/2013 |
| ThPOK transgene stably represses CD8 gene expression through the deacetylation of Cd8 loci in CD4 cell lineage commitment. | Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.
Rui J, Liu H, Zhu X, Cui Y, Liu X. | 10/20/2012 |
| The p65 subunit of NF-kappaB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3). | The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
Beauchef G, Bigot N, Kypriotou M, Renard E, Porée B, Widom R, Dompmartin-Blanchere A, Oddos T, Maquart FX, Demoor M, Boumediene K, Galera P., Free PMC Article | 03/24/2012 |
| comparing the promoter regions of the Th-POK gene between human and mouse, the region 3600 base pairs upstream from the transcription initiation site of the Th-POK gene was highly conserved | Identification of important regulatory region of Th-POK.
Shamsul Alam M. | 02/5/2011 |
| impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis | p300-mediated acetylation stabilizes the Th-inducing POK factor.
Zhang M, Zhang J, Rui J, Liu X. | 10/23/2010 |
| Thymoma neoplastic epithelial cells can induce Th-POK expression in T-cell subsets similarly to the normal thymic epithelial cells. In addition, there was no significant difference in Runx3 expression in T-cell subsets between normal thymi and thymomas. | Regulation of Th-POK and Runx3 in T cell development in human thymoma.
Tokunaga T, Hayashi A, Kadota Y, Shiono H, Inoue M, Sawabata N, Okumura M. | 06/14/2010 |
| Runx and ThPOK role in mechanisms of lineage-specific gene regulation in the process of T-cell commitments[review] | Runx and ThPOK: a balancing act to regulate thymocyte lineage commitment.
Egawa T. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group., Free PMC Article | 06/24/2009 |
| Chondroitin sulphate and its derived hydrolytic fragments (CSf) repress COL1A1 gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 transcription factors. | Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.
Renard E, Chadjichristos C, Kypriotou M, Beauchef G, Bordat P, Dompmartin A, Widom RL, Boumediene K, Pujol JP, Galéra P., Free PMC Article | 01/21/2010 |
| These data suggest that the regulation of COL1A1 gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1, and Sp3. | Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors.
Kypriotou M, Beauchef G, Chadjichristos C, Widom R, Renard E, Jimenez SA, Korn J, Maquart FX, Oddos T, Von Stetten O, Pujol JP, Galéra P. | 01/21/2010 |