| Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac. | Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac.
Qu T, Cha L, Liu H, Tian L, Hu X, Zou H, Feng Y, Sun C, Cao J, Guo W, Qiu F, Zhou B. | 09/6/2024 |
| UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4. | UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
Li Y, Liu L. | 06/21/2024 |
| Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria. | Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.
Mi D, Yanatori I, Zheng H, Kong Y, Hirayama T, Toyokuni S. | 06/5/2024 |
| Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase. | Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.
Scott S, Li Y, Bermek O, Griffith JD, Lemon SM, Choi KH., Free PMC Article | 12/20/2023 |
| Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach. | Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
Huang L, Ma B, Zhang C, Shi J, Shen R, Zhang E, Lian C, Wang C, Liu J., Free PMC Article | 11/3/2023 |
| The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2. | The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
Han S, Jin X, Hu T, Chi F. | 09/1/2023 |
| MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis. | MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
Xiang L, Zeng Q, Liu J, Xiao M, He D, Zhang Q, Xie D, Deng M, Zhu Y, Liu Y, Bo H, Liu X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K. | 01/28/2023 |
| PCBP2 knockdown promotes ferroptosis in malignant mesothelioma. | PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
Yue L, Luo Y, Jiang L, Sekido Y, Toyokuni S. | 05/7/2022 |
| Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA. | Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.
Janecki DM, Swiatkowska A, Szpotkowska J, Urbanowicz A, Kabacińska M, Szpotkowski K, Ciesiołka J., Free PMC Article | 01/15/2022 |
| PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis. | PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis.
Yoshimura M, Honda H, Sasagasako N, Mori S, Hamasaki H, Suzuki SO, Ishii T, Ninomiya T, Kira JI, Iwaki T. | 01/1/2022 |
| Upregulation of a novel LncRNA AC104958.2 stabilized by PCBP2 promotes proliferation and microvascular invasion in hepatocellular carcinoma. | Upregulation of a novel LncRNA AC104958.2 stabilized by PCBP2 promotes proliferation and microvascular invasion in hepatocellular carcinoma.
Ma Z, Li S, Wang Y, Zhang J, Zeng X. | 11/13/2021 |
| PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E. | PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
Wang X, Guo Q, Wang H, Yuan X, Wang B, Lobie PE, Zhu T, Tan S, Wu Z. | 10/23/2021 |
| Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer. | Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer.
Yuan C, Chen M, Cai X. | 08/14/2021 |
| LncRNA ST8SIA6-AS1 promotes colorectal cancer cell proliferation, migration and invasion by regulating the miR-5195/PCBP2 axis. | LncRNA ST8SIA6-AS1 promotes colorectal cancer cell proliferation, migration and invasion by regulating the miR-5195/PCBP2 axis.
Huang CM, Cao GY, Yang CX, Chen Y, Liu GD, Xu BW, Zhang X. | 04/3/2021 |
| Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. | Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30.
Rizzotto D, Zaccara S, Rossi A, Galbraith MD, Andrysik Z, Pandey A, Sullivan KD, Quattrone A, Espinosa JM, Dassi E, Inga A., Free PMC Article | 03/27/2021 |
| LINC02535 co-functions with PCBP2 to regulate DNA damage repair in cervical cancer by stabilizing RRM1 mRNA. | LINC02535 co-functions with PCBP2 to regulate DNA damage repair in cervical cancer by stabilizing RRM1 mRNA.
Wen D, Huang Z, Li Z, Tang X, Wen X, Liu J, Li M. | 03/6/2021 |
| PCBP2 promotes the development of glioma by regulating FHL3/TGF-beta/Smad signaling pathway. | PCBP2 promotes the development of glioma by regulating FHL3/TGF-β/Smad signaling pathway.
Mao J, Sun Z, Cui Y, Du N, Guo H, Wei J, Hao Z, Zheng L., Free PMC Article | 02/6/2021 |
| PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions. | PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions.
Ishii T, Igawa T, Hayakawa H, Fujita T, Sekiguchi M, Nakabeppu Y., Free PMC Article | 01/23/2021 |
| Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone. | Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.
Bae DH, Lane DJR, Siafakas AR, Sutak R, Paluncic J, Huang MLH, Jansson PJ, Rahmanto YS, Richardson DR. | 12/5/2020 |
| Study describes molecular mechanism by which type 1 diabetes (T1D)-associated lncRNA Lnc13 regulates virus-induced pancreatic beta-cell inflammation. Lnc13 acts as a linker between the RNA binding protein PCBP2 and the 3'UTR of STAT1 to stabilize the mRNA of STAT1. This stabilization leads to increased activation of the STAT1 proinflammatory pathway, contributing to local inflammation and eventual beta-cell destruction. | The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA.
Gonzalez-Moro I, Olazagoitia-Garmendia A, Colli ML, Cobo-Vuilleumier N, Postler TS, Marselli L, Marchetti P, Ghosh S, Gauthier BR, Eizirik DL, Castellanos-Rubio A, Santin I., Free PMC Article | 08/1/2020 |
| demonstrate that PCBP2 and ZNF467 impact adipogenic but not osteogenic differentiation, further supporting evidence that AMSCs and BMSCs appear to be adapted to their microenvironment | Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells.
Gluscevic M, Paradise CR, Dudakovic A, Karperien M, Dietz AB, van Wijnen AJ, Deyle DR. | 04/11/2020 |
| We summarize DMT1 expression depending on the types of cell or tissue and the function and mechanism of one of the iron chaperones, PCBP2 | DMT1 and iron transport.
Yanatori I, Kishi F. | 02/15/2020 |
| A proteomic search for MYMLR-binding proteins identified PCBP2, while it was also found that MYMLR places a 557-kb upstream enhancer region in the proximity of the MYC promoter in cooperation with PCBP2. | Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction.
Kajino T, Shimamura T, Gong S, Yanagisawa K, Ida L, Nakatochi M, Griesing S, Shimada Y, Kano K, Suzuki M, Miyano S, Takahashi T., Free PMC Article | 12/28/2019 |
| PCBP2 appears to be an oncogenic splicing factor. A growing body of evidence has shown that PCBP1 regulates alternative splicing, translation, and RNA stability of many cancer-related genes. Taking together, PCBP1 has distinctive tumor suppressive functions, and increasing PCBP1 expression may represent a new approach for cancer treatment. | Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor.
Guo J, Jia R. | 10/5/2019 |
| Results show that PCBP2 interacts with NLRX1 to participate in the NLRX1-induced degradation of MAVS and the inhibition of antiviral responses during HCV infection. | NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2.
Qin Y, Xue B, Liu C, Wang X, Tian R, Xie Q, Guo M, Li G, Yang D, Zhu H., Free PMC Article | 06/8/2019 |