| Association of TAS2R16 gene (rs860170, rs978739, rs1357949) polymorphisms and TAS2R16 serum levels in patients with age-related macular degeneration. | Association of TAS2R16 gene (rs860170, rs978739, rs1357949) polymorphisms and TAS2R16 serum levels in patients with age-related macular degeneration.
Inokaityte I, Gedvilaite G, Liutkeviciene R. | 02/6/2024 |
| TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts. | TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.
Zhou Z, Xi R, Liu J, Peng X, Zhao L, Zhou X, Li J, Zheng X, Xu X., Free PMC Article | 02/12/2022 |
| Suppression of hTAS2R16 Signaling by Umami Substances. | Suppression of hTAS2R16 Signaling by Umami Substances.
Rhyu MR, Kim Y, Misaka T., Free PMC Article | 02/27/2021 |
| Dual binding mode of ""bitter sugars"" to their human bitter taste receptor target. | Dual binding mode of "bitter sugars" to their human bitter taste receptor target.
Fierro F, Giorgetti A, Carloni P, Meyerhof W, Alfonso-Prieto M., Free PMC Article | 10/24/2020 |
| We did not find any statistically significant association between risk of developing sporadic colorectal cancer and selected single nucleotide polymorphisms. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (Ptrend of = 0.0071). | Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.
Barontini J, Antinucci M, Tofanelli S, Cammalleri M, Dal Monte M, Gemignani F, Vodicka P, Marangoni R, Vodickova L, Kupcinskas J, Vymetalkova V, Forsti A, Canzian F, Stein A, Moreno V, Mastrodonato N, Tavano F, Panza A, Barale R, Landi S, Campa D., Free PMC Article | 06/2/2018 |
| genetic association studies in populations in Northern Europe, Maghreb, and Sri Lanka: Data suggest that SNPs in TAS2R50 (rs1376251), TRPM5 (rs800345), and TAS2R16 (rs860170) are associated with cultural food preferences; TAS2R16 (rs860170) strongly differentiates populations and is associated to salicin bitterness perception. (TRPM5 = transient receptor potential cation channel subfamily M member 5) | A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Risso DS, Giuliani C, Antinucci M, Morini G, Garagnani P, Tofanelli S, Luiselli D. | 03/17/2018 |
| Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response. | Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.
Chen DE, Willick DL, Ruckel JB, Floriano WB., Free PMC Article | 09/26/2015 |
| No significant association between rs702424 alleles and salicin bitter taste recognition, implying that this site does not contribute to salicin phenotypic variance. | Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA., Free PMC Article | 07/25/2015 |
| Results showed that individuals with at least one derived T-allele at polymorphic site 516 have a higher sensitivity to salicin bitterness compared with individuals homozygous for the ancestral G-allele. | Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA., Free PMC Article | 10/25/2014 |
| Bitter taste receptor polymorphisms in TAS2R16 may be associated with human aging | Bitter taste receptor polymorphisms and human aging.
Campa D, De Rango F, Carrai M, Crocco P, Montesanto A, Canzian F, Rose G, Rizzato C, Passarino G, Barale R., Free PMC Article | 05/11/2013 |
| The authors discuss the association between the TAS2R16 gene and the evolution of bitter taste receptors in different populations. | Selection on the human bitter taste gene, TAS2R16, in Eurasian populations.
Li H, Pakstis AJ, Kidd JR, Kidd KK. | 12/24/2011 |
| TAS2R16 is responsible for the bitterness of gentiobiose. | The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.
Sakurai T, Misaka T, Ueno Y, Ishiguro M, Matsuo S, Ishimaru Y, Asakura T, Abe K. | 01/15/2011 |
| molecular interaction between hTAS2R16 and beta-D-glucopyranoside | Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.
Sakurai T, Misaka T, Ishiguro M, Masuda K, Sugawara T, Ito K, Kobayashi T, Matsuo S, Ishimaru Y, Asakura T, Abe K., Free PMC Article | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesBitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans.
Mangold JE, Payne TJ, Ma JZ, Chen G, Li MD. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM, Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM. | 03/13/2008 |
| Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence, especially in African-Americans. | Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.
Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM., Free PMC Article | 01/21/2010 |
| Functional variants in both TAS2R16 and TAS2R38 correlate with alcohol consumption in African-American families. | Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM, Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM. | 01/21/2010 |
| TAS2R16 is present in taste receptor cells on the tongue and is activated by bitter beta-glucopyranosides, and mediates bitter taste | The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.
Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. | 01/21/2010 |