| Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes. | Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.
Nolden AA, Behrens M, McGeary JE, Meyerhof W, Hayes JE., Free PMC Article | 07/2/2024 |
| Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort. | Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.
Turner A, Veysey M, Keely S, Scarlett CJ, Lucock M, Beckett EL., Free PMC Article | 09/4/2021 |
| Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor. | Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor.
Zhu H, Liu L, Ren L, Chen J, Peng L, Shi C, Wang X, Hu S, Zhang C, Gu M, Li X. | 01/9/2021 |
| Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells. | Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells.
Singh N, Shaik FA, Myal Y, Chelikani P. | 03/21/2020 |
| In summary, genetic variations in T2R3/4 bitterness receptors may modify the papillary thyroid carcinoma (PTC) risk, and the genetically modified thyroid hormone level by those variations may be linked with the PTC-T2Rs association | Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females.
Choi JH, Lee J, Yang S, Lee EK, Hwangbo Y, Kim J., Free PMC Article | 11/2/2019 |
| demonstrate that Lys117, an important CRAC residue, is crucial in the reported cholesterol sensitivity of T2R4. Interestingly, cholesterol sensitivity of T2R4 was observed at quinine concentrations in the lower mM range. | Cholesterol modulates bitter taste receptor function.
Pydi SP, Jafurulla M, Wai L, Bhullar RP, Chelikani P, Chattopadhyay A. | 10/28/2017 |
| This study is the first to show an inhibitory downstream action of a T2R4 agonist on Rac1 function. | Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4.
Sidhu C, Jaggupilli A, Chelikani P, Bhullar RP. | 02/18/2017 |
| Data indicate that KLK/R motif in C-terminus performs functional role in bitter taste receptor T2R4 signaling. | The structure-function role of C-terminus in human bitter taste receptor T2R4 signaling.
Upadhyaya J, Singh N, Bhullar RP, Chelikani P. | 10/3/2015 |
| The antagonist ability of ABA was tested using another T2R4 agonist, yohimbine. Our results suggest that ABA does not inhibit yohimbine-induced T2R4 activity. | Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4.
Pydi SP, Jaggupilli A, Nelson KM, Abrams SR, Bhullar RP, Loewen MC, Chelikani P. | 07/4/2015 |
| Data indicate that the itter blockers and agonists share the same orthosteric site in bitter taste receptor T2R4. | Amino acid derivatives as bitter taste receptor (T2R) blockers.
Pydi SP, Sobotkiewicz T, Billakanti R, Bhullar RP, Loewen MC, Chelikani P., Free PMC Article | 01/31/2015 |
| these results show that rhodopsin N-terminal 33 amino acids enhance expression of T2R4 by 2.5-fold and do not cause perturbations in the receptor structure. | Role of rhodopsin N-terminus in structure and function of rhodopsin-bitter taste receptor chimeras.
Pydi SP, Chakraborty R, Bhullar RP, Chelikani P. | 05/18/2013 |
| This study demonistrated that human TAS2R4 play the role of food preference behavior. | Behavioral analysis of Drosophila transformants expressing human taste receptor genes in the gustatory receptor neurons.
Adachi R, Sasaki Y, Morita H, Komai M, Shirakawa H, Goto T, Furuyama A, Isono K. | 12/8/2012 |