| MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-beta-Smad3/nephrin pathway. | MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-β-Smad3/nephrin pathway.
Wang T, Li C, Wang X, Liu F. | 11/15/2023 |
| S-SCAM inhibits Axin-dependent synaptic function of GSK3beta in a sex-dependent manner. | S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner.
Kearney G, Grau D, Nieves Torres D, Shin SM, Lee SH., Free PMC Article | 05/7/2022 |
| In summary,MAGI-2 and Fyn protect dendrin fromNedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI-2 in podocytes results in FSGS. | Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes.
Shirata N, Ihara KI, Yamamoto-Nonaka K, Seki T, Makino SI, Oliva Trejo JA, Miyake T, Yamada H, Campbell KN, Nakagawa T, Mori K, Yanagita M, Mundel P, Nishimori K, Asanuma K., Free PMC Article | 10/7/2017 |
| Magi2 is an essential component of the slit diaphragm complex that is required for nephrin localization and foot process formation. | Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.
Lefebvre J, Clarkson M, Massa F, Bradford ST, Charlet A, Buske F, Lacas-Gervais S, Schulz H, Gimpel C, Hata Y, Schaefer F, Schedl A. | 05/28/2016 |
| MAGI-2 has a critical role in maintaining the functional structure of the slit diaphragm and this molecule has an essential role in the functioning of the kidney filtration barrier. | MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney.
Ihara K, Asanuma K, Fukuda T, Ohwada S, Yoshida M, Nishimori K. | 05/7/2016 |
| We showed the expression patterns of MAGI-2 in detail in adult mice. Significant Venus expression was detected in various regions of the brain, also detected in glomeruli of the kidney. We found the novel expression of MAGI-2 in the testis. | Generation of Venus reporter knock-in mice revealed MAGI-2 expression patterns in adult mice.
Ihara K, Nishimura T, Fukuda T, Ookura T, Nishimori K. | 07/4/2015 |
| MAGI-2 is required for the integrity of the kidney filter and podocyte survival. | MAGI-2 scaffold protein is critical for kidney barrier function.
Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL., Free PMC Article | 05/2/2015 |
| elevation of S-SCAM expression in the excitatory neurons of forebrain was sufficient to induce an schizophrenia-like phenotype in mice. | S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.
Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH., Free PMC Article | 04/18/2015 |
| In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. | Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis.
Bauß K, Knapp B, Jores P, Roepman R, Kremer H, Wijk EV, Märker T, Wolfrum U. | 02/21/2015 |
| ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct. | Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells.
Qi Y, Ge JY, Wang YN, Liu HY, Li YM, Liu ZH, Cui XL. | 08/31/2013 |
| Two subsynaptic domains, one containing IgSF9b for synaptic adhesion and the other containing gephyrin and GABAA receptors for synaptic transmission, are interconnected through S-SCAM and neuroligin 2. | The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.
Woo J, Kwon SK, Nam J, Choi S, Takahashi H, Krueger D, Park J, Lee Y, Bae JY, Lee D, Ko J, Kim H, Kim MH, Bae YC, Chang S, Craig AM, Kim E., Free PMC Article | 08/31/2013 |
| ARIP1 is a key molecule for the regulation of the action of activin in neurones, and also that decreased ARIP1 expression in the lesioned brain may be beneficial to the neurotrophic and neuroprotective roles of activin A in recovery after brain injury. | Localisation and role of activin receptor-interacting protein 1 in mouse brain.
Liu HY, Wang YN, Ge JY, Li N, Cui XL, Liu ZH. | 06/8/2013 |
| These experiments identify MAGI-2 as a strong candidate for linking TARP/AMPA receptor complexes to a wide range of other postsynaptic molecules and pathways and advance our knowledge of protein interactions at mammalian CNS synapses. | Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain.
Deng F, Price MG, Davis CF, Mori M, Burgess DL., Free PMC Article | 01/21/2010 |
| Localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of CA3 pyramidal cells. | Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus.
Yamada A, Irie K, Deguchi-Tawarada M, Ohtsuka T, Takai Y. | 01/21/2010 |