| Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells. | Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells.
Jin X, Yang S, Lu X, Chen X, Dai W., Free PMC Article | 06/13/2024 |
| REG3A overexpression functions as a negative predictive and prognostic biomarker in rectal cancer patients receiving CCRT. | REG3A overexpression functions as a negative predictive and prognostic biomarker in rectal cancer patients receiving CCRT.
Li WS, Chen TJ, Lee SW, Yang CC, Tian YF, Kuo YH, Tsai HH, Wu LC, Yeh CF, Shiue YL, Chou CL, Lai HY. | 01/8/2024 |
| REG3A promotes proliferation and DDP resistance of ovarian cancer cells by activating the PI3K/Akt signaling pathway. | REG3A promotes proliferation and DDP resistance of ovarian cancer cells by activating the PI3K/Akt signaling pathway.
Jiang L, Liu Y, Liu M, Zheng Y, Chen L, Shan F, Ji J, Cao Y, Kai H, Kang X. | 01/4/2024 |
| Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice. | Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice.
Yu L, Zhou Y, Sun S, Wang R, Yu W, Xiao H, Yu Z, Luo C. | 12/15/2023 |
| Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2. | Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.
He X, Zhou H. | 09/20/2023 |
| [Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway]. | [Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway].
Quan YC, Wang LY, Wang ZY, Gao W, Che FY. | 08/16/2023 |
| Regenerating islet-derived protein 3-alpha is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease. | Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease.
DePriest BP, Li H, Bidgoli A, Onstad L, Couriel D, Lee SJ, Paczesny S., Free PMC Article | 05/28/2022 |
| The regenerating protein 3A: a crucial molecular with dual roles in cancer. | The regenerating protein 3A: a crucial molecular with dual roles in cancer.
Wang L, Quan Y, Zhu Y, Xie X, Wang Z, Wang L, Wei X, Che F., Free PMC Article | 04/2/2022 |
| Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer. | Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer.
Wang L, Tuo H, Song Z, Li W, Peng Y., Free PMC Article | 02/26/2022 |
| Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes. | Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.
Sands M, Frank JA, Maglinger B, McLouth CJ, Trout AL, Turchan-Cholewo J, Stowe AM, Fraser JF, Pennypacker KR., Free PMC Article | 02/12/2022 |
| Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression. | Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression.
Guo J, Liao M, Hu X, Wang J., Free PMC Article | 02/12/2022 |
| Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3alpha and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis. | Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3α and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis.
Yang J, Syed F, Xia Y, Sanyal AJ, Shah VH, Chalasani N, Zheng X, Yu Q, Lou Y, Li W., Free PMC Article | 12/4/2021 |
| Secretome screening reveals immunomodulating functions of IFNalpha-7, PAP and GDF-7 on regulatory T-cells. | Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells.
Ding M, Malhotra R, Ottosson T, Lundqvist M, Mebrahtu A, Brengdahl J, Gehrmann U, Bäck E, Ross-Thriepland D, Isaksson I, Magnusson B, Sachsenmeier KF, Tegel H, Hober S, Uhlén M, Mayr LM, Davies R, Rockberg J, Schiavone LH., Free PMC Article | 11/13/2021 |
| REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway. | REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.
Zhang H, Corredor ALG, Messina-Pacheco J, Li Q, Zogopoulos G, Kaddour N, Wang Y, Shi BY, Gregorieff A, Liu JL, Gao ZH., Free PMC Article | 08/14/2021 |
| Myocardial Accumulations of Reg3A, Reg3gamma and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis. | Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.
Gajawada P, Cetinkaya A, von Gerlach S, Kubin N, Burger H, Näbauer M, Grinninger C, Rolf A, Schönburg M, Choi YH, Kubin T, Richter M., Free PMC Article | 05/15/2021 |
| Anti-tumor effect of single-chain antibody to Reg3a in colorectal cancer. | Anti-tumor effect of single-chain antibody to Reg3a in colorectal cancer.
Du P, Wang X, Yin T, Zhang X, Zhang Z, Yu W, Wang M, Luo C, Yu L. | 03/13/2021 |
| Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) confers protection against hepatic fibrosis through downregulation of transforming growth factor beta receptor II. | Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) confers protection against hepatic fibrosis through downregulation of transforming growth factor β receptor II.
Li Q, Li H, Lv Y, Zhang Q, Zhang X, Li S, Zheng X, Wang Y, Hao Z. | 09/26/2020 |
| Authors found no association between rs7588571 and cGVHD (A vs. G: HR 0.94, 95% CI 0.77-1.15, P = 0.55) or ecGVHD (HR 1.04, 95% CI 0.84-1.29, P = 0.69) (Table 2, Fig. 1). | Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD.
Rashidi A, Shanley R, Anasetti C, Waller EK, Scott BL, Blazar BR, Weisdorf DJ., Free PMC Article | 04/18/2020 |
| ncRNA REG1CP forms an RNA-DNA triplex with a homopurine stretch at the distal promoter of the REG3A gene, through which the DNA helicase FANCJ (FANCJ) is tethered to the core promoter of REG3A protein (REG3A) and facilitates REG3A transcription. | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription.
Yari H, Jin L, Teng L, Wang Y, Wu Y, Liu GZ, Gao W, Liang J, Xi Y, Feng YC, Zhang C, Zhang YY, Tabatabaee H, La T, Yang RH, Wang FH, Yan XG, Farrelly M, Scott R, Liu T, Thorne RF, Guo ST, Zhang XD., Free PMC Article | 03/14/2020 |
| Survival signal REG3alpha prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. | Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.
Zhao D, Kim YH, Jeong S, Greenson JK, Chaudhry MS, Hoepting M, Anderson ER, van den Brink MR, Peled JU, Gomes AL, Slingerland AE, Donovan MJ, Harris AC, Levine JE, Ozbek U, Hooper LV, Stappenbeck TS, Ver Heul A, Liu TC, Reddy P, Ferrara JL., Free PMC Article | 09/14/2019 |
| REG3A SNP was not associated with aGVHD | Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples.
Rashidi A, Shanley R, Yohe SL, Thyagarajan B, Curtsinger J, Anasetti C, Waller EK, Scott BL, Blazar BR, Weisdorf DJ., Free PMC Article | 07/20/2019 |
| Results show that REG3beta binds the surface of extracellular vesicles (EVs), through its lectin domain, thereby interfering with the internalization of EVs by target cells and compromising their functionality. This mechanism could be important in pancreatic ductal adenocarcinoma (PDAC), since we detected REG3beta+ EVs in blood from PDAC patients. | REG3β modifies cell tumor function by impairing extracellular vesicle uptake.
Bonjoch L, Gironella M, Iovanna JL, Closa D., Free PMC Article | 01/12/2019 |
| Data show that regenerating family member 3 alpha protein (REG3A) can modulate specific cutaneous inflammatory responses and that the decrease in cutaneous REG3A exacerbates toll-like receptor 3 (TLR3)-mediated inflammation in diabetic skin wounds. | Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.
Wu Y, Quan Y, Liu Y, Liu K, Li H, Jiang Z, Zhang T, Lei H, Radek KA, Li D, Wang Z, Lu J, Wang W, Ji S, Xia Z, Lai Y., Free PMC Article | 09/22/2018 |
| Data found that REG3A was significantly downregulated in Gastric cancer and closely related with patient prognoses. REG3A overexpression suppressed the invasion and proliferation promoting apoptosis of GC cells. While REG3A knockdown promoted the invasion, and proliferation suppressing | REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway.
Qiu YS, Liao GJ, Jiang NN., Free PMC Article | 09/15/2018 |
| Mice with hepatocytes that express hREG3A, which travels to the intestinal lumen, are less sensitive to colitis than control mice. Suggest reduced oxidative stress preserves the gut microbiota and its ability to prevent inflammation. | Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.
Darnaud M, Dos Santos A, Gonzalez P, Augui S, Lacoste C, Desterke C, De Hertogh G, Valentino E, Braun E, Zheng J, Boisgard R, Neut C, Dubuquoy L, Chiappini F, Samuel D, Lepage P, Guerrieri F, Doré J, Bréchot C, Moniaux N, Faivre J. | 04/28/2018 |