| Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular GABA transporter 1 (Vgat1) in the orofacial pain and temperature perception pathway under low estrogen conditions. | Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular GABA transporter 1 (Vgat1) in the orofacial pain and temperature perception pathway under low estrogen conditions.
Zhang J, Da Y, Lu J, Sun Y, Wang H, Wang K, Wang W, Qin L, Jia J. | 10/22/2022 |
| GAT-1, which is predominantly presynaptically located, is the major GABA transporter in the hippocampus under baseline, quiescent conditions. | A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.
Kersanté F, Rowley SC, Pavlov I, Gutièrrez-Mecinas M, Semyanov A, Reul JM, Walker MC, Linthorst AC., Free PMC Article | 12/7/2013 |
| we report the identification of a unique amino acid motif in the vesicular GABA transporter (VGAT) that controls its synaptic localization and activity-dependent recycling | Sorting of the vesicular GABA transporter to functional vesicle pools by an atypical dileucine-like motif.
Santos MS, Park CK, Foss SM, Li H, Voglmaier SM., Free PMC Article | 09/7/2013 |
| The results demonstrate a malfunction of GAT-1 in thalamic astrocytes of a well-established genetic model of absence epilepsy, and indicate that this abnormality is not a reflection of a general pathology affecting all astrocytic functions. | Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures.
Pirttimaki T, Parri HR, Crunelli V., Free PMC Article | 08/10/2013 |
| This study provides evidence that the GAT-1-mediated regulation of extracellular GABA can modulate glutamatergic transmission at the subthalamopallidal synapse in the rat globus pallidus. | GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus.
Jin XT, Paré JF, Smith Y., Free PMC Article | 12/22/2012 |
| BDNF enhances the time span of GAT-1 molecules at the plasma membrane of astrocytes. | Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes.
Vaz SH, Jørgensen TN, Cristóvão-Ferreira S, Duflot S, Ribeiro JA, Gether U, Sebastião AM., Free PMC Article | 01/21/2012 |
| These experiments confirmed that, when a high concentration of GABA is present in the cytoplasm, GAT1 can operate in reverse mode. The reverse transport was affected by the the internal concentrations of Na+ and Cl-. | GABA reverse transport by the neuronal cotransporter GAT1: influence of internal chloride depletion.
Bertram S, Cherubino F, Bossi E, Castagna M, Peres A. | 12/31/2011 |
| Data indicate that GAT-1 and GAT-3 represent different target sites through which GABA reuptake may subserve complementary regulation of GABAergic transmission in the rat globus pallidus. | Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus.
Jin XT, Paré JF, Smith Y., Free PMC Article | 09/17/2011 |
| Excessive expression of GAT-1 as well as GAT-3 and GABA receptor alpha1 subunits in hippocampal tremor may provide potential therapeutic targets for genetic epilepsy. | Up-regulation of GABA transporters and GABA(A) receptor α1 subunit in tremor rat hippocampus.
Mao X, Guo F, Yu J, Min D, Wang Z, Xie N, Chen T, Shaw C, Cai J. | 09/10/2011 |
| The GABA transporter GAT-1 is upregulated with no change in GAT-3 or glutamate transporters. | Upregulation of the GABA transporter GAT-1 in the gracile nucleus in the spared nerve injury model of neuropathic pain.
Gosselin RD, Bebber D, Decosterd I. | 10/23/2010 |
| Results indicate that calpain activation/inhibition in GABAergic terminals may influence the scaffolding and surface expression of GABA transporter GAT1 under normal conditions or imbalance GAT1-mediated GABAergic transmission under pathological states | Modification of the cytosolic regions of GABA transporter GAT1 by calpain.
Baliova M, Knab A, Franekova V, Jursky F. | 01/21/2010 |
| GAT-1 mRNA (a prevalent presynaptic component) correlates with avoidances and escapes in rat cerebellum, while glial fibrillary acid protein mRNA (an astrocytic component) correlates with freezings in cerebellum and cerebral cortex. | Synaptic mRNAs are modulated by learning.
Ferrara E, Cefaliello C, Eyman M, De Stefano R, Giuditta A, Crispino M. | 01/21/2010 |
| We examined GAT-1, a marker of chandelier cartridges. We show that the numbers of arrays of chandelier axons are reduced by 36% in the ventral prelimbic cortex of isolation-reared rats, compared with their socially-housed litter mates. | Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats.
Bloomfield C, French SJ, Jones DN, Reavill C, Southam E, Cilia J, Totterdell S. | 01/21/2010 |
| glutamine 291 residue is involved in the interaction with sodium or in maintaining the cation accessibility to the transporter(GAT-1) | Role of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1.
Mari SA, Soragna A, Castagna M, Santacroce M, Perego C, Bossi E, Peres A, Sacchi VF., Free PMC Article | 01/21/2010 |
| GAT1 mRNA expression is initially up-regulated in the ipsilateral vestibular nucleus and then undergoes a bilateral increase 50 h after labyrinthectomy. | Effects of unilateral labyrinthectomy on GAD, GAT1 and GABA receptor gene expression in the rat vestibular nucleus.
Horii A, Kitahara T, Smith PF, Darlington CL, Masumura C, Kubo T. | 01/21/2010 |
| GAT-1 immunohistochemistry is the most robust means of visualising chandelier cell cartridges in rat medial prefrontal cortex and hippocampus. | A comparison of possible markers for chandelier cartridges in rat medial prefrontal cortex and hippocampus.
Hardwick C, French SJ, Southam E, Totterdell S. | 01/21/2010 |
| The data, show that GAT-1 contributes to the termination of the synaptic action of mossy fiber-released GABA and rules out its involvement in depolarization-dependent GABA release. | Blockade of the membranal GABA transporter potentiates GABAergic responses evoked in pyramidal cells by mossy fiber activation after seizures.
Vivar C, Gutiérrez R. | 01/21/2010 |
| During neocortical development the expression of GABA transporter in the cerebral cortex slightly precedes the complete maturation of inhibitory synaptogenesis and suggests that it may contribute to the formation of neocortical GABAergic circuitry. | Postnatal development of the vesicular GABA transporter in rat cerebral cortex.
Minelli A, Alonso-Nanclares L, Edwards RH, DeFelipe J, Conti F. | 01/21/2010 |
| The steady expression of vesicular GABA transporter mRNA and protein after photothrombosis indicates that the exocytotic release mechanism of GABA is not affected by ischemia. | Stable expression of the vesicular GABA transporter following photothrombotic infarct in rat brain.
Frahm C, Siegel G, Grass S, Witte OW. | 01/21/2010 |
| GABA transporter can exist in either of two mutually exclusive phosphorylation states and that the relative abundance of these states determines in part the relative subcellular distribution of the transporter | Regulation of a gamma-aminobutyric acid transporter by reciprocal tyrosine and serine phosphorylation.
Quick MW, Hu J, Wang D, Zhang HY. | 01/21/2010 |
| two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat GAT1 | Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1).
Farhan H, Korkhov VM, Paulitschke V, Dorostkar MM, Scholze P, Kudlacek O, Freissmuth M, Sitte HH. | 01/21/2010 |
| GAT-1 modulates synaptic transmission under physiological conditions in the early postnatal rat hippocampus. | GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus.
Sipilä S, Huttu K, Voipio J, Kaila K., Free PMC Article | 01/21/2010 |
| SNAP-25 binding to syntaxin 1A greatly potentiates the physical interaction of syntaxin 1A with GAT-1 and significantly enhances the syntaxin 1A-mediated inhibition of GAT-1 reuptake function. | SNAP-25/syntaxin 1A complex functionally modulates neurotransmitter gamma-aminobutyric acid reuptake.
Fan HP, Fan FJ, Bao L, Pei G. | 01/21/2010 |
| significant role for GAT-1 in the control of the excitability of immature hippocampal neurons and networks. | GAT-1 acts to limit a tonic GABA(A) current in rat CA3 pyramidal neurons at birth.
Sipilä ST, Voipio J, Kaila K. | 01/21/2010 |
| study of an acutely recycling pool of endogenous gamma-aminobutyric acid transporters (GAT1) in cortical neurons that comprises approximately one-third of total cellular GAT1 | Trafficking of the plasma membrane gamma-aminobutyric acid transporter GAT1. Size and rates of an acutely recycling pool.
Wang D, Quick MW. | 01/21/2010 |