| ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer. | ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer.
Zhou F, Ai W, Zhang Y, Hu Q, Gan M, Wang JB, Han T., Free PMC Article | 10/22/2022 |
| ARHGEF3 Associated with Invasion, Metastasis, and Proliferation in Human Osteosarcoma. | ARHGEF3 Associated with Invasion, Metastasis, and Proliferation in Human Osteosarcoma.
Gong J, Tang W, Lv B, Zhang S, Fan T, Gao G, Chen D, Liu Y., Free PMC Article | 09/25/2021 |
| Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins. | Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins.
Singh N, Reyes-Ordoñez A, Compagnone MA, Moreno JF, Leslie BJ, Ha T, Chen J., Free PMC Article | 07/31/2021 |
| Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease. | Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease.
Wang Y, Jiang Q, Cai H, Xu Z, Wu W, Gu B, Li L, Cai W., Free PMC Article | 02/20/2021 |
| The predicted expression of the ARHGEF3 gene in fibroblasts (effect, -0.48; P = 9.8 x 10-04) was associated with Major Depression. | DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.
Story Jovanova O, Nedeljkovic I, Spieler D, Walker RM, Liu C, Luciano M, Bressler J, Brody J, Drake AJ, Evans KL, Gondalia R, Kunze S, Kuhnel B, Lahti J, Lemaitre RN, Marioni RE, Swenson B, Himali JJ, Wu H, Li Y, McRae AF, Russ TC, Stewart J, Wang Z, Zhang G, Ladwig KH, Uitterlinden AG, Guo X, Peters A, Räikkönen K, Starr JM, Waldenberger M, Wray NR, Whitsel EA, Sotoodehnia N, Seshadri S, Porteous DJ, van Meurs J, Mosley TH, McIntosh AM, Mendelson MM, Levy D, Hou L, Eriksson JG, Fornage M, Deary IJ, Baccarelli A, Tiemeier H, Amin N., Free PMC Article | 10/5/2019 |
| This is the first study describing the involvement of XPLN in the regulation of the mTORC2-SPARC axis, and these findings may help uncover regulatory mechanisms mediated by XPLN in idiopathic pulmonary fibrosis | XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts.
Kamio K, Azuma A, Usuki J, Matsuda K, Inomata M, Nishijima N, Itakura S, Hayashi H, Kashiwada T, Kokuho N, Atsumi K, Yamaguchi T, Fujita K, Saito Y, Abe S, Kubota K, Gemma A. | 03/17/2018 |
| Our findings suggest that increased expression of ARHGEF3 plays a critical oncogenic role in nasopharyngeal carcinoma pathogenesis | The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis.
Liu TH, Zheng F, Cai MY, Guo L, Lin HX, Chen JW, Liao YJ, Kung HF, Zeng YX, Xie D., Free PMC Article | 12/9/2017 |
| Data suggest that modulation of ARHGEF3 gene expression in humans with a promoter-localized SNP plays a role in human megakaryocytes and human platelet function-a finding resulting from the biological follow-up of human genetic studies. Arhgef3 KO mice partially recapitulate the human phenotype. | SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.
Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS., Free PMC Article | 09/23/2017 |
| ARHGEF3 has a crucial role in myeloid differentiation. | ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.
D'Amato L, Dell'Aversana C, Conte M, Ciotta A, Scisciola L, Carissimo A, Nebbioso A, Altucci L., Free PMC Article | 06/28/2016 |
| ARHGEF3 and RHOA are potential regulators of a number of genes in bone cells, with influences on ACTA2 evident in both osteoblast-like and osteoclast-like cells. | Influence of ARHGEF3 and RHOA knockdown on ACTA2 and other genes in osteoblasts and osteoclasts.
Mullin BH, Mamotte C, Prince RL, Wilson SG., Free PMC Article | 01/10/2015 |
| XPLN is an endogenous inhibitor of mTORC2. | XPLN is an endogenous inhibitor of mTORC2.
Khanna N, Fang Y, Yoon MS, Chen J., Free PMC Article | 12/7/2013 |
| the association between rs7646054 in ARHGEF3 and bone mineral density observed in Caucasians was not replicated in the chinese samples. | Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.
Li GH, Kung AW, Huang QY, Li GH, Kung AW, Huang QY., Free PMC Articles: PMC2946578, PMC2946578 | 04/2/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study identifies three loci associated with mean platelet volume.
Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Völzke H, Peters A, Illig T, Ouwehand WH, Meitinger T, Wichmann HE, Döring A., Free PMC Article | 01/11/2009 |
| genetic variation in ARHGEF3 plays a role in the determination of bone density in Caucasian women. This data implicates the RhoGTPase-RhoGEF pathway in osteoporosis. | Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.
Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG, Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG., Free PMC Articles: PMC2427258, PMC2427258 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesMutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.
Li GH, Kung AW, Huang QY, Li GH, Kung AW, Huang QY. Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis.
Mullin BH, Prince RL, Mamotte C, Spector TD, Hart DJ, Dudbridge F, Wilson SG. Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.
Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG, Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG. | 06/4/2008 |
| a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC | XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K. | 01/21/2010 |