| IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours. | IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours.
Zang Z, Yin Y, Liu C, Zhu Q, Huang X, Li H, Yang R., Free PMC Article | 05/13/2024 |
| Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA[+] B cells. | Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA(+) B cells.
Xie Y, Huang Y, Li ZY, Jiang W, Shi NX, Lu Y, Cao G, Yin Z, Lin XJ., Free PMC Article | 05/13/2024 |
| ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han. | ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han.
Wu Z, Li H, Xu H, Feng F, Zhang F, Zhang S, Wang L, Li Y. | 04/17/2024 |
| Interleukin-21 receptor gene polymorphism (rs2285452 A/G) is associated with susceptibility to Behcet's disease. | Interleukin-21 receptor gene polymorphism (rs2285452 A/G) is associated with susceptibility to Behçet's disease.
Lahmar R, Chabchoub E, Zemni R, Anis M, Ghannouchi N, Slama FBH. | 07/25/2023 |
| IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and High Levels of IL-21 Are Associated with Rheumatoid Arthritis in Mexican Patients. | IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and High Levels of IL-21 Are Associated with Rheumatoid Arthritis in Mexican Patients.
Carreño-Saavedra NM, Reyes-Pérez IV, Machado-Sulbaran AC, Martínez-Bonilla GE, Ramírez-Dueñas MG, Muñoz-Valle JF, Olaya-Valdiviezo V, García-Iglesias T, Martínez-García EA, Sánchez-Hernández PE., Free PMC Article | 05/5/2023 |
| Expression of Interleukin-21 and Interleukin-21 receptor in lymphocytes derived from tumor-draining lymph nodes of breast cancer. | Expression of Interleukin-21 and Interleukin-21 receptor in lymphocytes derived from tumor-draining lymph nodes of breast cancer.
Balouchi-Anaraki S, Mohammadsadeghi S, Norouzian M, Rasolmali R, Talei AR, Mehdipour F, Ghaderi A. | 10/8/2022 |
| Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency. | Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency.
Cagdas D, Mayr D, Baris S, Worley L, Langley DB, Metin A, Aytekin ES, Atan R, Kasap N, Bal SK, Dmytrus J, Heredia RJ, Karasu G, Torun SH, Toyran M, Karakoc-Aydiner E, Christ D, Kuskonmaz B, Uçkan-Çetinkaya D, Uner A, Oberndorfer F, Schiefer AI, Uzel G, Deenick EK, Keller B, Warnatz K, Neven B, Durandy A, Sanal O, Ma CS, Özen A, Stepensky P, Tezcan I, Boztug K, Tangye SG., Free PMC Article | 02/5/2022 |
| WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides. | WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides.
Carneiro VL, da Silva HBF, Queiroz GA, Veiga RV, Oliveira PRS, Carneiro NVQ, Pires AO, da Silva RR, Sena F, Belitardo E, Nascimento R, Silva M, Marques CR, Costa RDS, Alcantra-Neves NM, Barreto ML, Cooper PJ, Figueiredo CA., Free PMC Article | 08/28/2021 |
| HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells. | HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells.
Dalel J, Ung SK, Hayes P, Black SL, Joseph S, King DF, Makinde J, Gilmour J, The IAVI Protocol C investigators list., Free PMC Article | 07/17/2021 |
| The IL21/IL21R axis reduced the growth and invasion of NSCLC cells via inhibiting Wnt/betacatenin signaling and PDL1 expression. The present results may provide a novel molecular target for NSCLC diagnosis and therapy. | IL‑21/IL‑21R inhibit tumor growth and invasion in non‑small cell lung cancer cells via suppressing Wnt/β‑catenin signaling and PD‑L1 expression.
Xue D, Yang P, Wei Q, Li X, Lin L, Lin T., Free PMC Article | 08/1/2020 |
| IL-21R rs2285452 AA genotype increases the risk of hepatitis B-related hepatocellular carcinoma in Chinese patients. | Interleukin-21 receptor gene polymorphism is associated with hepatitis B virus-related hepatocellular carcinoma in Chinese patients.
Liu T, Song J, Zhang M, Li S, Zhang J, Hu X, Zhao Z, Peng W, Wu Q, Bai H, Li Y, Lu X, Ying B., Free PMC Article | 12/14/2019 |
| in IL-21R (rs3093390C/T) gene polymorphism, allele frequency of T is statistically different in the hepatitis B virus spontaneous clearance group compared to chronic hepatitis B virus infection cases | Association between Interleukin-21 and Interleukin-21 receptor gene polymorphisms with susceptibility to chronic hepatitis B virus infection and HBV spontaneous clearance in Iranian population.
Shoraka S, Mohebbi SR, Hosseini SM, Hosseini Razavi A, Hatami Y, Sharifian A, Rostami-Nejad M, Asadzadeh Aghdaei H, Zali MR. | 05/4/2019 |
| Results showed the upregulation of IL-21R in gastric cancer (GC) associated with tumor size and lymphatic metastasis and acted as an independent prognostic factor of a poor survival and recurrence in GC. IL-21R functioned as an oncogenic factor and alleviated the suppressive effects of miR-125a in GC cells. | IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer.
Yan L, Zhang J, Guo D, Ma J, Shui SF, Han XW., Free PMC Article | 03/16/2019 |
| The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R). | IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.
Jandl C, Liu SM, Cañete PF, Warren J, Hughes WE, Vogelzang A, Webster K, Craig ME, Uzel G, Dent A, Stepensky P, Keller B, Warnatz K, Sprent J, King C., Free PMC Article | 11/17/2018 |
| bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14(+) cells in enhanced osteoclast formation. | IL21R expressing CD14(+)CD16(+) monocytes expand in multiple myeloma patients leading to increased osteoclasts.
Bolzoni M, Ronchetti D, Storti P, Donofrio G, Marchica V, Costa F, Agnelli L, Toscani D, Vescovini R, Todoerti K, Bonomini S, Sammarelli G, Vecchi A, Guasco D, Accardi F, Palma BD, Gamberi B, Ferrari C, Neri A, Aversa F, Giuliani N., Free PMC Article | 07/8/2017 |
| Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals. | Endothelial interleukin-21 receptor up-regulation in peripheral artery disease.
Wang T, Cunningham A, Houston K, Sharma AM, Chen L, Dokun AO, Lye RJ, Spolski R, Leonard WJ, Annex BH., Free PMC Article | 12/17/2016 |
| expression of IL-21 and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade | Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease.
Guan LJ, Wang X, Meng S, Shi LF, Jiang WJ, Xiao L, Shi XH, Xu J, Zhang JA. | 12/19/2015 |
| interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency. | Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency.
Stepensky P, Keller B, Abuzaitoun O, Shaag A, Yaacov B, Unger S, Seidl M, Rizzi M, Weintraub M, Elpeleg O, Warnatz K., Free PMC Article | 10/17/2015 |
| IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE. | Upregulated interleukin-21 receptor on B cells associated with the downregulation of IgE in patients with allergic rhinitis.
Jen HY, Yang YH, Chiang BL, Chuang YH. | 09/12/2015 |
| IL-21/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity. | The elevated expression of Th17-related cytokines and receptors is associated with skin lesion severity in early systemic sclerosis.
Zhou Y, Hou W, Xu K, Han D, Jiang C, Mou K, Li Y, Meng L, Lu S. | 09/5/2015 |
| STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers | STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
Wilson RP, Ives ML, Rao G, Lau A, Payne K, Kobayashi M, Arkwright PD, Peake J, Wong M, Adelstein S, Smart JM, French MA, Fulcher DA, Picard C, Bustamante J, Boisson-Dupuis S, Gray P, Stepensky P, Warnatz K, Freeman AF, Rossjohn J, McCluskey J, Holland SM, Casanova JL, Uzel G, Ma CS, Tangye SG, Deenick EK., Free PMC Article | 08/15/2015 |
| Human neutrophils in peripheral blood express functional IL-21 receptors. | Human peripheral neutrophils express functional IL-21 receptors.
Takeda Y, Nara H, Araki A, Asao H. | 06/27/2015 |
| IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients. | IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients.
Hsu CS, Hsu SJ, Liu WL, Chen CL, Liu CJ, Chen PJ, Chen DS, Kao JH. | 04/19/2014 |
| Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease. | Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease.
Wood B, Sikdar S, Choi SJ, Virk S, Alhejaily A, Baetz T, LeBrun DP. | 12/14/2013 |
| Data suggest that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production. | IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection.
Li N, Zhu Q, Li Z, Han Q, Chen J, Lv Y, Wang Y, Zeng X, Chen Y, Yang C, Liu Z. | 10/26/2013 |