| optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1. | Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane.
Wang P, Wang WJ, Choi-Nurvitadhi J, Lescaille Y, Murray JW, Wolkoff AW., Free PMC Article | 07/4/2020 |
| Bile transporters OATP1/MRP2 mRNA expression ratio in liver tissue decreased with dimethylnitrosamine-induced liver injury, model of liver cirrhosis. | Pre-Hepatectomy Assessment of Bile Transporter Expression by Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis.
Kim J, Kim T, Hong KS, Moon H, Oh IK, Lee SM, Hohenwalter MD, Zimmerman MA, Cronin DC, Hong JC. | 03/17/2018 |
| Oatp1a1 has a role in acute liver congestion as seen in gadoxetate disodium-enhanced MRI | Features of acute liver congestion on gadoxetate disodium-enhanced MRI in a rat model: Role of organic anion-transporting polypeptide 1A1.
Shimizu A, Kobayashi A, Motoyama H, Sakai H, Yamada A, Yoshizawa A, Momose M, Kadoya M, Miyagawa S. | 07/30/2016 |
| These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib. | Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats.
Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, Matsuura K, Hasegawa T. | 04/30/2016 |
| Oatp1a1 and Oatp2b1 expression levels are decreased by intestinal ischemia reperfusion. | Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate.
Maruyama H, Ogura J, Fujikawa A, Terada Y, Tsujimoto T, Koizumi T, Kuwayama K, Kobayashi M, Yamaguchi H, Iseki K. | 09/6/2014 |
| persistent elevation of serum bilirubin during regeneration of small liver was suggested to be due to sustained low uptake from the sinusoids by repressed OATP1 and low export from hepatocytes to bile duct by repressed MRP2 on the canalicular membrane. | Gene expression of ATP-binding cassette transporters during liver regeneration after 90% hepatectomy in rats.
Kimura N, Hakamada K, Ikenaga SK, Umehara Y, Toyoki Y, Sasaki M. | 09/29/2012 |
| Although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools. | PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.
Choi JH, Murray JW, Wolkoff AW., Free PMC Article | 04/23/2011 |
| Insights of this protein in kidneyin its cellular localization and response during ischemic acute kidney injury and recovery from it. | Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion.
Kwon O, Wang WW, Miller S. | 01/21/2010 |
| Topology and glycosylation of rat hepatocyte Oatp1a1 was examined. | Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains.
Wang P, Hata S, Xiao Y, Murray JW, Wolkoff AW. | 01/21/2010 |
| this is the first report suggesting that HGF regulates Oatp1 protein level and that the ameliorative effects of HGF in cholestasis was induced, at least in part, by correcting the down-regulation of the Oatp1 protein level | Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes.
Iwakiri T, Okumura M, Matsunaga N, Ichihara E, Shiotsuki S, Nagata M, Kumagai Y, Kai H, Arimori K. | 01/21/2010 |
| Show TNF-alpha dependent loss of Oatp1 during obstructive cholestatis. | Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver.
Geier A, Dietrich CG, Trauner M, Gartung C. | 01/21/2010 |
| Upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. | Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.
Dietrich CG, Martin IV, Porn AC, Voigt S, Gartung C, Trautwein C, Geier A. | 01/21/2010 |
| Oatp1-mediated uptake of trihydroxy bile acids taurocholate and glycocholate was four-to eightfold below that of corresponding dihydroxy conjugates. | Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake.
Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW. | 01/21/2010 |
| Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. | Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2.
Meng LJ, Wang P, Wolkoff AW, Kim RB, Tirona RG, Hofmann AF, Pang KS. | 01/21/2010 |
| results suggest that urinary E(2)-17betaG excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption | Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats.
Gotoh Y, Kato Y, Stieger B, Meier PJ, Sugiyama Y. | 01/21/2010 |
| results demonstrate that both membrane targeting and functional activity of organic anion transporter 1 are controlled by the extent of N-glycosylation | N-glycosylation controls functional activity of Oatp1, an organic anion transporter.
Lee TK, Koh AS, Cui Z, Pierce RH, Ballatori N. | 01/21/2010 |
| The lower OAT1 expression is responsible for the diminished secreted load of this organic anion in chronic renal failure. | Altered renal elimination of organic anions in rats with chronic renal failure.
Mónica Torres A, Mac Laughlin M, Muller A, Brandoni A, Anzai N, Endou H. | 01/21/2010 |
| These findings identify the site of oatp1a1 phosphorylation and demonstrate that it is an ordered process, in which phosphorylation at S634 precedes that at S635. | Rat organic anion transporting protein 1A1 (Oatp1a1): purification and phosphopeptide assignment.
Xiao Y, Nieves E, Angeletti RH, Orr GA, Wolkoff AW., Free PMC Article | 01/21/2010 |
| TNF-alpha represents the master cytokine responsible for HNF1-dependent down-regulation of Ntcp, Oatp1, and Oatp2 in CCl(4)-induced toxic liver injury. | Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. | 01/21/2010 |
| oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function | Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.
Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, Wolkoff AW. | 01/21/2010 |