| Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. | Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization.
Ray U, Roy D, Jin L, Thirusangu P, Staub J, Xiao Y, Kalogera E, Wahner Hendrickson AE, Cullen GD, Goergen K, Oberg AL, Shridhar V., Free PMC Article | 12/11/2021 |
| Several hits were discovered, and data have been uploaded to PubChem. This study describes the first high-throughput optical screening assay for secreted phospholipase A2 inhibitors based on a phospholipid vesicle substrate | Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.
Ewing H, Fernández-Vega V, Spicer TP, Chase P, Brown S, Scampavia L, Roush WR, Riley S, Rosen H, Hodder P, Lambeau G, Gelb MH. | 01/20/2018 |
| Studies indicate that the expression of secreted phospholipases A2 (sPLA2s), most notably the group IIA, III and X enzymes, is dysregulated in various malignant tissues. | Secreted phospholipases A2 in cancer: diverse mechanisms of action.
Brglez V, Lambeau G, Petan T. | 08/22/2015 |
| Studies indicate that phospholipase A2 receptor 1 (PLA2R1) may act as a clearance or signaling receptor for secreted phospholipase A2 (sPLA2s). | Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.
Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K, Lambeau G. | 08/22/2015 |
| sPLA2GIII expression may be used as a risk factor for lymph node metastasis and a prognostic marker in colorectal cancer. In addition, sPLA2GIII and sPLA2GX may play opposing roles in colorectal carcinogenesis | Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer.
Kazama S, Kitayama J, Hiyoshi M, Taketomi Y, Murakami M, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Yamaguchi H, Nozawa H, Ishihara S, Sunami E, Watanabe T. | 08/8/2015 |
| Data indicate that the expression of genes encoding hGIIA, hGIII and hGX sPLA2s (PLA2G2A, PLA2G3 and PLA2G10, respectively) in breast tumour biopsies differs from that in normal tissues. | Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.
Brglez V, Pucer A, Pungerčar J, Lambeau G, Petan T. | 05/3/2014 |
| we describe that PLA2G3 gene silencing produced a marked inhibition of xanthine/xanthine oxidase induced cell death, and that PLA2G3 polymorphisms are associated with Alzheimer disease in a Spanish case-control sample. | PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.
Martínez-García A, Sastre I, Recuero M, Aldudo J, Vilella E, Mateo I, Sánchez-Juan P, Vargas T, Carro E, Bermejo-Pareja F, Rodríguez-Rodríguez E, Combarros O, Rosich-Estrago M, Frank A, Valdivieso F, Bullido MJ, Martínez-García A, Sastre I, Recuero M, Aldudo J, Vilella E, Mateo I, Sánchez-Juan P, Vargas T, Carro E, Bermejo-Pareja F, Rodríguez-Rodríguez E, Combarros O, Rosich-Estrago M, Frank A, Valdivieso F, Bullido MJ. | 05/28/2011 |
| The availability of the human group III phospholipase A(2) (hIIIPLA(2)) amino acid sequence offers an opportunity to study its structural features by modeling. | Human group III PLA2 as a drug target: structural analysis and inhibitor binding studies.
Hariprasad G, Kumar M, Kaur P, Singh TP, Kumar RP. | 01/15/2011 |
| Secreted PLA2 III induces apoptosis of primary cortical neurons in culture by suppressing production of Bcl-xl, promoting Bax, augmenting caspase 3 and cleaving alpha-fodrin. | Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons.
Wang G, Zhou D, Wang C, Gao Y, Zhou Q, Qian G, DeCoster MA. | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesPLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.
Martínez-García A, Sastre I, Recuero M, Aldudo J, Vilella E, Mateo I, Sánchez-Juan P, Vargas T, Carro E, Bermejo-Pareja F, Rodríguez-Rodríguez E, Combarros O, Rosich-Estrago M, Frank A, Valdivieso F, Bullido MJ, Martínez-García A, Sastre I, Recuero M, Aldudo J, Vilella E, Mateo I, Sánchez-Juan P, Vargas T, Carro E, Bermejo-Pareja F, Rodríguez-Rodríguez E, Combarros O, Rosich-Estrago M, Frank A, Valdivieso F, Bullido MJ. Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. | 12/2/2009 |
| This study showed that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that transgenic mice overexpressing human PLA2G3 spontaneously develop skin inflammation. | Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
Sato H, Taketomi Y, Isogai Y, Masuda S, Kobayashi T, Yamamoto K, Murakami M., Free PMC Article | 01/21/2010 |
| a potential functional link between PLA2G3 and atherosclerosis, as has recently been proposed for PLA2G5 and PLA2G10. | Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
Sato H, Kato R, Isogai Y, Saka G, Ohtsuki M, Taketomi Y, Yamamoto K, Tsutsumi K, Yamada J, Masuda S, Ishikawa Y, Ishii T, Kobayashi T, Ikeda K, Taguchi R, Hatakeyama S, Hara S, Kudo I, Itabe H, Murakami M., Free PMC Article | 01/21/2010 |
| the biological action of group III sPLA(2) depends on its N-terminal domain | Human group III phospholipase A2 suppresses adenovirus infection into host cells. Evidence that group III, V and X phospholipase A2s act on distinct cellular phospholipid molecular species.
Mitsuishi M, Masuda S, Kudo I, Murakami M. | 01/21/2010 |
| potential contribution of sPLA2-III to neuronal differentiation and its function under certain conditions | Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Masuda S, Yamamoto K, Hirabayashi T, Ishikawa Y, Ishii T, Kudo I, Murakami M. | 01/21/2010 |
| sPLA(2)-III may have a role in cancer development by stimulating tumor cell growth and angiogenesis | Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).
Murakami M, Masuda S, Shimbara S, Ishikawa Y, Ishii T, Kudo I. | 01/21/2010 |
| cellular arachidonate (AA) release and prostaglandin (PG) production are regulated by novel classes of secretory phospholipase A(2)s (sPLA(2)s), groups III and XII | Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).
Murakami M, Masuda S, Shimbara S, Bezzine S, Lazdunski M, Lambeau G, Gelb MH, Matsukura S, Kokubu F, Adachi M, Kudo I. | 01/21/2010 |
| Lys 43 and Asp 46 in rhUG are critical residues for the sPLA2-inhibitory activity of UG | Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.
Chowdhury B, Mantile-Selvaggi G, Miele L, Cordella-Miele E, Zhang Z, Mukherjee AB. | 01/21/2010 |