| Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4. | Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4.
Rong B, Chen X, Xie G, Han L, Chen H, Sun Q, Zhou Y., Free PMC Article | 06/22/2023 |
| Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism. | Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism.
Gonzalez MA, Olivas IM, Bencomo-Alvarez AE, Rubio AJ, Barreto-Vargas C, Lopez JL, Dang SK, Solecki JP, McCall E, Astudillo G, Velazquez VV, Schenkel K, Reffell K, Perkins M, Nguyen N, Apaflo JN, Alvidrez E, Young JE, Lara JJ, Yan D, Senina A, Ahmann J, Varley KE, Mason CC, Eide CA, Druker BJ, Nurunnabi M, Padilla O, Bajpeyi S, Eiring AM., Free PMC Article | 12/31/2022 |
| An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. | An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M, Traumatic Stress Brain Study Group., Free PMC Article | 06/5/2021 |
| Low G0S2 gene expression levels in peripheral blood may be a genetic marker of acute myocardial infarction in patients with stable coronary atherosclerotic disease: A retrospective clinical study. | Low G0S2 gene expression levels in peripheral blood may be a genetic marker of acute myocardial infarction in patients with stable coronary atherosclerotic disease: A retrospective clinical study.
Wang X, Meng H, Ruan J, Chen W, Meng F., Free PMC Article | 04/17/2021 |
| G0S2 hypermethylation is a hallmark of rapidly recurrent or fatal ACC, amenable to targeted assessment using routine molecular diagnostics. Assessing G0S2 methylation is straightforward, feasible for clinical decision-making, and will enable the direction of efficacious adjuvant therapies for patients with aggressive ACC. | Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma.
Mohan DR, Lerario AM, Else T, Mukherjee B, Almeida MQ, Vinco M, Rege J, Mariani BMP, Zerbini MCN, Mendonca BB, Latronico AC, Marie SKN, Rainey WE, Giordano TJ, Fragoso MCBV, Hammer GD., Free PMC Article | 07/11/2020 |
| In addition to its role as a lipolytic inhibitor, G0S2 is capable of directly promoting TG synthesis by acting as a lipid-synthesizing enzyme. | Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G(0)/G(1) switch gene 2 (G0S2).
Zhang X, Xie X, Heckmann BL, Saarinen AM, Gu H, Zechner R, Liu J., Free PMC Article | 05/16/2020 |
| We conclude that the RNF126/BAG6 complex contributes to G0S2 degradation and that interventions to prevent G0S2 degradation may offer a therapeutic strategy for managing ischemic diseases. | A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G(0)/G(1) switch gene 2.
Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S., Free PMC Article | 05/9/2020 |
| ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen | G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer.
Yim CY, Bikorimana E, Khan E, Warzecha JM, Shin L, Rodriguez J, Dmitrovsky E, Freemantle SJ, Spinella MJ., Free PMC Article | 08/11/2018 |
| Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta-mediated G0S2 expression. | Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells.
Zhao NQ, Li XY, Wang L, Feng ZL, Li XF, Wen YF, Han JX., Free PMC Article | 08/11/2018 |
| G0S2 functions as a master regulator of tissue-specific balance of TG storage vs. mobilization, partitioning of metabolic fuels between adipose and liver, and the whole-body adaptive energy response. | G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux.
Zhang X, Heckmann BL, Campbell LE, Liu J., Free PMC Article | 11/25/2017 |
| PML/RARalpha synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia differentiation and potentially, clinical remission. | Activation of G0S2 is coordinated by recruitment of PML/RARα and C/EBPε to its promoter during ATRA-induced APL differentiation.
Zhang F, Zhu YL, Deng WL, Zhu J, Zhang J. | 09/2/2017 |
| differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level | Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue.
Skopp A, May M, Janke J, Kielstein H, Wunder R, Flade-Kuthe R, Kuthe A, Jordan J, Engeli S. | 12/17/2016 |
| Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL). | Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells.
Zagani R, El-Assaad W, Gamache I, Teodoro JG., Free PMC Article | 08/6/2016 |
| Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells. | Lipolytic inhibitor G0/G1 switch gene 2 inhibits reactive oxygen species production and apoptosis in endothelial cells.
Wang Y, Zhang Y, Zhu Y, Zhang P. | 09/26/2015 |
| Data indicate that the peptide corresponding to residues Lys-20 to Ala-52 from G0S2 Inhibits ATGL in the nanomolar range. | A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase.
Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, Schweiger M, Cornaciu I, Lass A, Zimmermann R, Zechner R, Oberer M., Free PMC Article | 02/14/2015 |
| reelin expression is altered by Abeta leading to impaired reelin signaling. | The g0/g1 switch gene 2 is an important regulator of hepatic triglyceride metabolism.
Wang Y, Zhang Y, Qian H, Lu J, Zhang Z, Min X, Lang M, Yang H, Wang N, Zhang P., Free PMC Article | 04/19/2014 |
| A new mechanism that controls proliferation in K562 cells, suggesting a possible tumor suppressor function for G0S2 in leukemia cells. | G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol.
Yamada T, Park CS, Shen Y, Rabin KR, Lacorazza HD., Free PMC Article | 03/22/2014 |
| This linked G0S2 subcellular localization to G0S2 transcriptional repression. The potential mechanisms responsible for this G0S2 repression are examined. | Repression of exogenous gene expression by the retinoic acid target gene G0S2.
Ma T, Dong JP, Sekula DJ, Fei DL, Lamph WW, Henderson M, Lu Y, Blumen S, Freemantle SJ, Dmitrovsky E., Free PMC Article | 11/2/2013 |
| Data indicate that downregulation of G0S2 in adipose tissue could represent one of the underlying causes leading to increased lipolysis in the insulin-resistant state. | G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase.
Schweiger M, Paar M, Eder C, Brandis J, Moser E, Gorkiewicz G, Grond S, Radner FP, Cerk I, Cornaciu I, Oberer M, Kersten S, Zechner R, Zimmermann R, Lass A., Free PMC Article | 03/9/2013 |
| Gene expression profiles showed that G0/G1 switch 2 was up-regulated in epidermolysis bullosa subtypes. | Epidermolysis bullosa - a group of skin diseases with different causes but commonalities in gene expression.
Knaup J, Verwanger T, Gruber C, Ziegler V, Bauer JW, Krammer B. | 12/22/2012 |
| Reduced mRNA and protein content of Plin and G0S2 and borderline increased ATGL protein in sc adipose tissue from poorly controlled type 2 diabetic subjects. | Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes.
Nielsen TS, Kampmann U, Nielsen RR, Jessen N, Orskov L, Pedersen SB, Jørgensen JO, Lund S, Møller N. | 09/29/2012 |
| findings are compatible with the notion that the ATGL-G0S2 complex is an important long-term regulator of lipolysis under physiological conditions such as fasting in humans | Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue.
Nielsen TS, Vendelbo MH, Jessen N, Pedersen SB, Jørgensen JO, Lund S, Møller N. | 10/15/2011 |
| DNA methylation of G0S2 can be an important biomarker for squamous lung cancer. | Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches.
Kusakabe M, Kutomi T, Watanabe K, Emoto N, Aki N, Kage H, Hamano E, Kitagawa H, Nagase T, Sano A, Yoshida Y, Fukami T, Murakawa T, Nakajima J, Takamoto S, Ota S, Fukayama M, Yatomi Y, Ohishi N, Takai D. | 03/29/2010 |
| mRNA expression of G0S2 was regulated mainly by DNA methylation in squamous lung cancer cell lines. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists.
Kusakabe M, Watanabe K, Emoto N, Aki N, Kage H, Nagase T, Nakajima J, Yatomi Y, Ohishi N, Takai D. | 01/21/2010 |
| G0S2 encodes a mitochondrial protein that specifically interacts with Bcl-2 and promotes apoptosis by preventing the formation of protective Bcl-2/Bax heterodimers | Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.
Welch C, Santra MK, El-Assaad W, Zhu X, Huber WE, Keys RA, Teodoro JG, Green MR., Free PMC Article | 01/21/2010 |