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    PAEP progestagen associated endometrial protein [ Homo sapiens (human) ]

    Gene ID: 5047, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA).

    Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA).
    Löb S, Vattai A, Kuhn C, Schmoeckel E, Mahner S, Wöckel A, Kolben T, Keil C, Jeschke U, Vilsmaier T.

    11/6/2021
    Glycodelin is internalized by peripheral monocytes.

    Glycodelin is internalized by peripheral monocytes.
    Hansen YBL, Myrhøj V, Sørensen S.

    05/29/2021
    Glycodelin regulates the numbers and function of peripheral natural killer cells.

    Glycodelin regulates the numbers and function of peripheral natural killer cells.
    Dixit A, Karande AA.

    05/22/2021
    Altered glycosylation of glycodelin in endometrial carcinoma.

    Altered glycosylation of glycodelin in endometrial carcinoma.
    Hautala LC, Pang PC, Antonopoulos A, Pasanen A, Lee CL, Chiu PCN, Yeung WSB, Loukovaara M, Bützow R, Haslam SM, Dell A, Koistinen H., Free PMC Article

    10/24/2020
    the findings of this study provide evidence that inhibiting these targets affects the expression of glycodelin and its immunosuppressive effect in nonsmall cell lung cancer tumours. Moreover, understanding the regulation of glycodelin expression may lead to the development of novel therapeutic approaches with which to weaken the immune system defence of NSCLC tumours in the future

    Pathways regulating the expression of the immunomodulatory protein glycodelin in non‑small cell lung cancer.
    Weber R, Meister M, Muley T, Thomas M, Sültmann H, Warth A, Winter H, Herth FJF, Schneider MA., Free PMC Article

    04/6/2019
    serum levels higher in preeclamptic group as compared to controls and higher in severe than in mild preeclampsia

    Maternal serum glycodelin levels in preeclampsia and its relationship with the severity of the disease.
    Dundar B, Dincgez Cakmak B, Aydin Boyama B, Karadag B, Ozgen G.

    12/22/2018
    This study indicate that GdA is a complex glycoprotein including up to 6 different glycoforms specifically expressed during the different phase of the menstrual cycle; in pathologic conditions such as endometriosis, the expression profile is altered possibly related to the impaired endometrial receptivity.

    Dysregulation of GdA Expression in Endometrium of Women With Endometriosis: Implication for Endometrial Receptivity.
    Focarelli R, Luddi A, De Leo V, Capaldo A, Stendardi A, Pavone V, Benincasa L, Belmonte G, Petraglia F, Piomboni P.

    11/10/2018
    The results from the present study suggested that PP14 may be a novel potential biomarker for PPROM, and may be developed into a lateral flow assay for bedside application to rapidly diagnose PPROM.

    Placental protein 14 as a potential biomarker for diagnosis of preterm premature rupture of membranes.
    Wang Y, Luo H, Che G, Li Y, Gao J, Yang Q, Zhou B, Gao L, Wang T, Liang Y, Zhang L., Free PMC Article

    10/20/2018
    PKCdelta, via MAPK pathway, is involved in the glycodelin-driven cell differentiation.

    Repressed PKCδ activation in glycodelin-expressing cells mediates resistance to phorbol ester and TGFβ.
    Hautala LC, Koistinen R, Koistinen H.

    12/2/2017
    inverse relationship between glycodelin immunostaining and cervical intraephitelial neoplasia grade in pregnant patients

    Glycodelin expression in pregnant patients with cervical intraepithelial neoplasia: a case-control study.
    Ciavattini A, Sopracordevole F, Di Giuseppe J, Lucarini G, Zizzi A, Moriconi L, Goteri G.

    01/14/2017
    the role of glycodelin-A in placental development and fetomaternal tolerance in early pregnancy.

    The Pleiotropic Effect of Glycodelin-A in Early Pregnancy.
    Lee CL, Lam KK, Vijayan M, Koistinen H, Seppala M, Ng EH, Yeung WS, Chiu PC.

    10/29/2016
    Altogether, the comprehensive characterization of glycodelin in non-small cell lung cancer provides strong support for its use as a biomarker with immune modulatory function.

    Glycodelin: A New Biomarker with Immunomodulatory Functions in Non-Small Cell Lung Cancer.
    Schneider MA, Granzow M, Warth A, Schnabel PA, Thomas M, Herth FJ, Dienemann H, Muley T, Meister M.

    05/21/2016
    The current study investigates the role of melanoma cell-secreted PAEP protein in regulating T cell function.

    Human malignant melanoma-derived progestagen-associated endometrial protein immunosuppresses T lymphocytes in vitro.
    Ren S, Chai L, Wang C, Li C, Ren Q, Yang L, Wang F, Qiao Z, Li W, He M, Riker AI, Han Y, Yu Q., Free PMC Article

    04/2/2016
    Both blood and tissue measurements of MUC-1 and GdA were significantly lower in women with recurrent implantation failure than in fertile women during the implantation window.

    Role of Mucin 1 and Glycodelin A in recurrent implantation failure.
    Bastu E, Mutlu MF, Yasa C, Dural O, Nehir Aytan A, Celik C, Buyru F, Yeh J.

    06/20/2015
    The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans.

    The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans.
    Schiefner A, Rodewald F, Neumaier I, Skerra A.

    04/18/2015
    Glycodelin-A treatment reduces the adverse effect of macrophage co-culture on human sperm motility.

    Glycodelin-A treatment reduces the adverse effect of macrophage co-culture on human sperm motility.
    Lee CL, Li K, Lam KK, Ng EH, Koistinen H, Seppälä M, Yeung WS, Chiu PC.

    02/14/2015
    Three months after myomectomy, endometrial glycodelin levels are significantly increased in infertile women with myoma.

    Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window.
    Farimani Sanoee M, Alizamir T, Faramarzi S, Saidijam M, Yadegarazari R, Shabab N, Rastgoo Haghi A, Alizadeh Z., Free PMC Article

    11/8/2014
    Glycodelin-A binds to KLF11 and is differentially activated and repressed by KLF11 in ovarian endometrium.

    KLF11 epigenetically regulates glycodelin-A, a marker of endometrial biology via histone-modifying chromatin mechanisms.
    Tabbaa ZM, Zheng Y, Daftary GS.

    08/30/2014
    Gd and GdA are commonly expressed in endometrial cancer tissue and seem to be of relevance in tumourigenesis.

    Immunosuppressive Glycodelin A is an independent marker for poor prognosis in endometrial cancer.
    Lenhard M, Heublein S, Kunert-Keil C, Vrekoussis T, Lomba I, Ditsch N, Mayr D, Friese K, Jeschke U., Free PMC Article

    06/28/2014
    Results suggest that PP-14 may play an important role in the pathogenesis of endometriosis.

    The role of placental protein 14 in the pathogenesis of endometriosis.
    Wang P, Zhu L, Zhang X., Free PMC Article

    04/12/2014
    Serum glycodelin levels did not predict endometrial receptivity in patients undergoing in vitro fertilization.

    Differential expression of serum glycodelin and insulin-like growth factor binding protein 1 in early pregnancy.
    Douglas NC, Thornton MH 2nd, Nurudeen SK, Bucur M, Lobo RA, Sauer MV., Free PMC Article

    03/22/2014
    Glycodelin-A is a potentially useful biomarker for ovarian endometriosis

    Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis.
    Kocbek V, Vouk K, Mueller MD, Rižner TL, Bersinger NA.

    01/18/2014
    The glycodelin A sequence from Met24 to Leu105 is necessary and sufficient to inhibit proliferation of T cells and induce apoptosis in them.

    Mapping the apoptosis inducing domain of an immunomodulatory protein: glycodelin A.
    Ponnalagu D, Karande AA.

    09/14/2013
    Glycodelin A was found to be an independent prognostic marker for poor prognosis in advanced ovarian cancer patients.

    Glycodelin A is a prognostic marker to predict poor outcome in advanced stage ovarian cancer patients.
    Scholz C, Heublein S, Lenhard M, Friese K, Mayr D, Jeschke U., Free PMC Article

    07/20/2013
    Data suggest that, in post-menarche girls (13-19 years) with endometriosis, peritoneal fluid levels of glycodelin A, IL-6 (interleukin-6), and TNF-alpha (tumor necrosis factor-alpha) are significantly higher than in control subjects.

    Selected cytokines and glycodelin A levels in serum and peritoneal fluid in girls with endometriosis.
    Drosdzol-Cop A, Skrzypulec-Plinta V.

    02/23/2013
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