| Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML. | Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML.
Marchesini M, Gherli A, Simoncini E, Tor LMD, Montanaro A, Thongon N, Vento F, Liverani C, Cerretani E, D'Antuono A, Pagliaro L, Zamponi R, Spadazzi C, Follini E, Cambò B, Giaimo M, Falco A, Sammarelli G, Todaro G, Bonomini S, Adami V, Piazza S, Corbo C, Lorusso B, Mezzasoma F, Lagrasta CAM, Martelli MP, La Starza R, Cuneo A, Aversa F, Mecucci C, Quaini F, Colla S, Roti G., Free PMC Article | 06/12/2024 |
| LINC00173 facilitates tumor progression by stimulating RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma. | LINC00173 facilitates tumor progression by stimulating RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma.
He SW, Liang YL, Zhang Y, Liu X, Gong S, Ye ML, Huang SY, Tan XR, Zhou SQ, Zhao Y, Liu N, Li YQ., Free PMC Article | 03/9/2023 |
| Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome. | Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome.
Alan Harris R, Archer KJ, Goodarzi MO, York TP, Rogers J, Dunaif A, McAllister JM, Strauss JF 3rd., Free PMC Article | 01/7/2023 |
| Increased PA2G4 Expression Is an Unfavorable Factor in Nasopharyngeal Carcinoma. | Increased PA2G4 Expression Is an Unfavorable Factor in Nasopharyngeal Carcinoma.
Xu Y, Cai H, Tu W, Ding L, Luo R., Free PMC Article | 01/22/2022 |
| EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development. | EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development.
Kim BS, Ko HR, Hwang I, Cho SW, Ahn JY., Free PMC Article | 01/8/2022 |
| Progression signature underlies clonal evolution and dissemination of multiple myeloma. | Progression signature underlies clonal evolution and dissemination of multiple myeloma.
Shen YJ, Mishima Y, Shi J, Sklavenitis-Pistofidis R, Redd RA, Moschetta M, Manier S, Roccaro AM, Sacco A, Tai YT, Mercier F, Kawano Y, Su NK, Berrios B, Doench JG, Root DE, Michor F, Scadden DT, Ghobrial IM., Free PMC Article | 12/11/2021 |
| HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer. | HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer.
Zhou Y, Yuan Y, Li L, Wang X, Quan Y, Liu C, Yu M, Hu X, Meng X, Zhou Z, Zhang CY, Chen X, Liu M, Wang C., Free PMC Article | 07/31/2021 |
| Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers. | Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.
Son HJ, Choi EJ, Yoo NJ, Lee SH. | 07/17/2021 |
| Ebp1 p48 promotes oncogenic properties in hepatocellular carcinoma through p38 MAPK/HIF1alpha activation and p53 downregulation. | Ebp1 p48 promotes oncogenic properties in hepatocellular carcinoma through p38 MAPK/HIF1α activation and p53 downregulation.
Bao Y, Suvesh M, Li X, Bai X, Li H, Li X, Xu D, Liu L. | 05/1/2021 |
| A structural view of PA2G4 isoforms with opposing functions in cancer. | A structural view of PA2G4 isoforms with opposing functions in cancer.
Stevenson BW, Gorman MA, Koach J, Cheung BB, Marshall GM, Parker MW, Holien JK., Free PMC Article | 03/13/2021 |
| Pseudogene PA2G4P4 promotes oncogene PA2G4 expression and nuclear translocation to affect glioblastoma cell viability and apoptosis. | Pseudogene PA2G4P4 promotes oncogene PA2G4 expression and nuclear translocation to affect glioblastoma cell viability and apoptosis.
Hou X, Tang W. | 01/16/2021 |
| Human Ebp1 rescues the synthetic lethal growth of fission yeast cells lacking Cdb4 and Nup184. | Human Ebp1 rescues the synthetic lethal growth of fission yeast cells lacking Cdb4 and Nup184.
Osemwenkhae OP, Sakuno T, Hirano Y, Asakawa H, Hayashi-Takanaka Y, Haraguchi T, Hiraoka Y. | 11/21/2020 |
| EBP1 expression was correlated with AR expression, histological grade, and lymphatic metastasis | The expression and prognostic role of EBP1 and relationship with AR in HER2+ breast cancer.
Liu J, Xu C, Xu D, Cao L, Xue H, Meng Q, Niu Y. | 08/1/2020 |
| Depletion of Ebp1 expression in primary colon cancer cells inhibits cell proliferation, colony forming, and invasion in vitro as well as tumor formation in vivo and enhances cell sensitivity to irradiation. We further demonstrated that Ebp1 interacts with TIF-90, a splice variant of transcription initiation factor IA (TIF-IA) of the RNA polymerase I complex. | Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.
Nguyen DQ, Hoang DH, Nguyen TTV, Ho HD, Huynh V, Shin JH, Ly QT, Thi Nguyen DD, Ghoda L, Marcucci G, Nguyen LXT. | 06/13/2020 |
| Competitive chemical inhibition of the MYCN-PA2G4 protein-protein interface had potent inhibitory effects on neuroblastoma tumorigenesis in vivo. | Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.
Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM. | 05/30/2020 |
| Ebp1 recruits ribosomal RNA expansion segment ES27L to the ribosomal tunnel exit via specific interactions with ribosomal RNA consensus sequences.Ebp1 blocks the ribosoamal tunnel exit with major interactions to the general uL23/uL29 docking site for nascent chain-associated factors complemented by eukaryote-specific eL19 and ribosomal RNA helix H59. | MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments.
Wild K, Aleksić M, Lapouge K, Juaire KD, Flemming D, Pfeffer S, Sinning I., Free PMC Article | 05/23/2020 |
| In this review, we will discuss the different functions of the two Ebp1 isoforms, p48 and p42, that may be responsible for the potentially dual role of Ebp1 in cancer growth. | The role of ErbB3 binding protein 1 in cancer: Friend or foe?
Nguyen DQ, Hoang DH, Nguyen Vo TT, Huynh V, Ghoda L, Marcucci G, Nguyen LXT. | 09/28/2019 |
| Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. | Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.
Li BB, Qian C, Gameiro PA, Liu CC, Jiang T, Roberts TM, Struhl K, Zhao JJ., Free PMC Article | 10/20/2018 |
| In this study, the authors demonstrated that overexpression of ErbB3-binding protein 1 (EBP1) promoted not only a reduction of wild type of p85 subunit of phosphoinositide 3-kinase but also oncogenic mutant forms of p85 which were identified in human cancers. | C-terminal domain of p42 Ebp1 is essential for down regulation of p85 subunit of PI3K, inhibiting tumor growth.
Hwang I, Kim CK, Ko HR, Park KW, Cho SW, Ahn JY., Free PMC Article | 05/5/2018 |
| The results demonstrate an important role of Ebp1 in promoting cell proliferation in Acute Myelogenous Leukemic Cells through the regulation of both rRNA synthesis and Proliferating Cell Nuclear Antigen expression. | Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells.
Nguyen le XT, Zhu L, Lee Y, Ta L, Mitchell BS. | 02/3/2018 |
| results show that EBP1 interacts directly with PPIns and associate with PtdIns(3,4,5)P3 in the nucleolus. | A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction.
Karlsson T, Altankhuyag A, Dobrovolska O, Turcu DC, Lewis AE., Free PMC Article | 05/20/2017 |
| The adapter function of EBP1 P42 stabilized the interaction of FBXW7 with its substrates and promoted FBXW7-mediated degradation of oncogenic targets, enhancing its overall tumor-suppressing function. Results establish distinct physical and functional interactions between FBXW7 and EBP1 isoforms, which yield their mechanistically unique isoform-specific functions of EBP1 in cancer. | Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.
Wang Y, Zhang P, Wang Y, Zhan P, Liu C, Mao JH, Wei G., Free PMC Article | 05/13/2017 |
| The combined determination of Ebp1 and p53 expression levels in cervical cancer patients could support the effective prediction of metastatic potential and patient prognosis. | Significance of Ebp1 and p53 protein expression in cervical cancer.
Liu L, Li XD, Chen HY, Cui JS, Xu DY. | 07/30/2016 |
| Data highlight the tissue specificity function of EBP1 isoforms and show that only the oncogene p48 activates MHC II expression in human solid tumors, via STAT1 phosphorylation, in order to affect tumor progression by triggering specific immune response. | EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.
Pisapia L, Barba P, Cortese A, Cicatiello V, Morelli F, Del Pozzo G., Free PMC Article | 05/28/2016 |
| Our results suggest a novel function of Ebp1 as a binding protein and negative regulator of Anxa2. The functional association between Anxa2 and EBP1 may participate in regulating cancer cell proliferation and invasion, contributing to cancer progression. | A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level.
Zhang F, Liu Y, Wang Z, Sun X, Yuan J, Wang T, Tian R, Ji W, Yu M, Zhao Y, Niu R. | 03/26/2016 |