| Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase. | Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase.
Moretti AIS, Baksheeva VE, Roman AY, De Bessa TC, Devred F, Kovacic H, Tsvetkov PO., Free PMC Article | 03/13/2024 |
| ARID1A loss induces P4HB to activate fibroblasts to support lung cancer cell growth, invasion, and chemoresistance. | ARID1A loss induces P4HB to activate fibroblasts to support lung cancer cell growth, invasion, and chemoresistance.
Huang R, Wu D, Zhang K, Hu G, Liu Y, Jiang Y, Wang C, Zheng Y., Free PMC Article | 02/16/2024 |
| Circular RNA P4HB promotes glycolysis and tumor progression by binding with PKM2 in lung adenocarcinoma. | Circular RNA P4HB promotes glycolysis and tumor progression by binding with PKM2 in lung adenocarcinoma.
Li H, Guo H, Huang Q, Wang S, Li X, Qiu M., Free PMC Article | 11/14/2023 |
| MiR-204-5p regulates HUVEC cell inflammation and apoptosis by targeting P4HB. | MiR-204-5p regulates HUVEC cell inflammation and apoptosis by targeting P4HB.
Chen J, Zhang K, Yang Y, Wu J. | 11/6/2023 |
| Establishment of prognostic model of bladder cancer based on apoptosis-related genes, in which P4HB promotes BLCA progression. | Establishment of prognostic model of bladder cancer based on apoptosis-related genes, in which P4HB promotes BLCA progression.
Zou Z, Li Z, Sun W, Gao W, Liu B, Liu J, Guo Y., Free PMC Article | 10/25/2023 |
| A meta-analysis and bioinformatics analysis of P4HB expression levels in the prognosis of cancer patients. | A meta-analysis and bioinformatics analysis of P4HB expression levels in the prognosis of cancer patients.
Wang F, Yu Z, Liu X, Hu F, Liu X, Fu X, Liu Y, Zou Z. | 05/23/2023 |
| Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis. | Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis.
Nagarkoti S, Kim YM, Ash D, Das A, Vitriol E, Read TA, Youn SW, Sudhahar V, McMenamin M, Hou Y, Boatwright H, Caldwell R, Essex DW, Cho J, Fukai T, Ushio-Fukai M., Free PMC Article | 02/14/2023 |
| A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of beta cell stress in type 1 diabetes. | A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes.
Syed F, Singhal D, Raedschelders K, Krishnan P, Bone RN, McLaughlin MR, Van Eyk JE, Mirmira RG, Yang ML, Mamula MJ, Wu H, Liu X, Evans-Molina C., Free PMC Article | 01/28/2023 |
| ERO1-PDI Redox Signaling in Health and Disease. | ERO1-PDI Redox Signaling in Health and Disease.
Jha V, Kumari T, Manickam V, Assar Z, Olson KL, Min JK, Cho J., Free PMC Article | 04/2/2022 |
| Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway. | Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q., Free PMC Article | 01/15/2022 |
| Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models. | Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models.
Parakh S, Perri ER, Vidal M, Sultana J, Shadfar S, Mehta P, Konopka A, Thomas CJ, Spencer DM, Atkin JD., Free PMC Article | 12/25/2021 |
| Expression of membrane protein disulphide isomerase A1 (PDIA1) disrupt a reducing microenvironment in endometrial epithelium for embryo implantation. | Expression of membrane protein disulphide isomerase A1 (PDIA1) disrupt a reducing microenvironment in endometrial epithelium for embryo implantation.
Fernando SR, Lee CL, Wong BP, Cheng KW, Lee YL, Chan MC, Ng EH, Yeung WS, Lee KF. | 10/16/2021 |
| Characterization of a complex phenotype (fever-dependent recurrent acute liver failure and osteogenesis imperfecta) due to NBAS and P4HB variants. | Characterization of a complex phenotype (fever-dependent recurrent acute liver failure and osteogenesis imperfecta) due to NBAS and P4HB variants.
Cotrina-Vinagre FJ, Rodríguez-García ME, Martín-Hernández E, Durán-Aparicio C, Merino-López A, Medina-Benítez E, Martínez-Azorín F. | 09/11/2021 |
| Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene. | Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene.
Kajihara D, Hon CC, Abdullah AN, Wosniak J Jr, Moretti AIS, Poloni JF, Bonatto D, Hashimoto K, Carninci P, Laurindo FRM., Free PMC Article | 08/21/2021 |
| Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state. | Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.
Alhammad R, Khunchai S, Tongmuang N, Limjindaporn T, Yenchitsomanus PT, Mutti L, Krstic-Demonacos M, Demonacos C., Free PMC Article | 07/31/2021 |
| Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer. | Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer.
Yang W, Wu X, Zhou F., Free PMC Article | 06/5/2021 |
| Regulation of nerve growth and patterning by cell surface protein disulphide isomerase. | Regulation of nerve growth and patterning by cell surface protein disulphide isomerase.
Cook GM, Sousa C, Schaeffer J, Wiles K, Jareonsettasin P, Kalyanasundaram A, Walder E, Casper C, Patel S, Chua PW, Riboni-Verri G, Raza M, Swaddiwudhipong N, Hui A, Abdullah A, Wajed S, Keynes RJ., Free PMC Article | 03/27/2021 |
| Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. | Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.
Yu J, Li T, Liu Y, Wang X, Zhang J, Wang X, Shi G, Lou J, Wang L, Wang CC, Wang L., Free PMC Article | 12/12/2020 |
| circP4HB enhances EMT and metastatic NSCLC disease through miR-133a-5p sequestration, leading to upregulation of vimentin. | The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p.
Wang T, Wang X, Du Q, Wu N, Liu X, Chen Y, Wang X. | 07/11/2020 |
| Compared with adjacent normal tissues, both the mRNA and protein levels of P4HB in ccRCC tissues were enhanced. | Overexpression of P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma.
Zhu Z, He A, Lv T, Xu C, Lin L, Lin J. | 06/13/2020 |
| Ras overactivation switches the pattern of PDIA1-dependent Rac1/Nox1 regulation, so that Ras-induced PDIA1 bypass can directly activate Rac1. PDIA1 may be a crucial regulator of redox-dependent adaptive processes related to cancer progression. | Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.
De Bessa TC, Pagano A, Moretti AIS, Oliveira PVS, Mendonça SA, Kovacic H, Laurindo FRM., Free PMC Article | 06/6/2020 |
| PDI role in the unfolded protein response and DNA repair in the glioblastoma. | Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy.
Liu Y, Ji W, Shergalis A, Xu J, Delaney AM, Calcaterra A, Pal A, Ljungman M, Neamati N, Rehemtulla A., Free PMC Article | 03/28/2020 |
| Our results confirm that P4HB plays a significant role in the regulatory network of HIF-1a. Therefore, HIF-1alpha and P4HB may be considered potential biomarkers of Gastric cancer (GC). | P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis.
Zhang J, Guo S, Wu Y, Zheng ZC, Wang Y, Zhao Y., Free PMC Article | 01/25/2020 |
| this study uncovers a molecular link between PDIA1 and Drp1 oxidoreduction. | Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence.
Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M., Free PMC Article | 12/14/2019 |
| High P4HB expression is associated with colon cancer. | P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling.
Zhou Y, Yang J, Zhang Q, Xu Q, Lu L, Wang J, Xia W., Free PMC Article | 06/1/2019 |