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    CLDN11 claudin 11 [ Homo sapiens (human) ]

    Gene ID: 5010, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.

    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
    Bilgiç A, Ferahkaya H, Karagöz H, Kılınç İ, Energin VM.

    10/26/2023
    MiR-205 suppressed the malignant behaviors of breast cancer cells by targeting CLDN11 via modulation of the epithelial-to-mesenchymal transition.

    MiR-205 suppressed the malignant behaviors of breast cancer cells by targeting CLDN11 via modulation of the epithelial-to-mesenchymal transition.
    Shen Y, Xu Y, Huang L, Chi Y, Meng L., Free PMC Article

    07/24/2021
    De novo stop-loss variants in CLDN11 cause hypomyelinating leukodystrophy.

    De novo stop-loss variants in CLDN11 cause hypomyelinating leukodystrophy.
    Riedhammer KM, Stockler S, Ploski R, Wenzel M, Adis-Dutschmann B, Ahting U, Alhaddad B, Blaschek A, Haack TB, Kopajtich R, Lee J, Murcia Pienkowski V, Pollak A, Szymanska K, Tarailo-Graovac M, van der Lee R, van Karnebeek CD, Meitinger T, Krägeloh-Mann I, Vill K., Free PMC Article

    04/24/2021
    Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells.

    Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells.
    Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A., Free PMC Article

    10/31/2020
    Over-expressed lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through regulation of miR-135b/CLDN11

    lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through miR-135b suppression to promote CLDN11 expression.
    Zhang XZ, Mao HL, Zhang SJ, Sun L, Zhang WJ, Chen QZ, Wang L, Liu HC.

    05/30/2020
    We suggest that although claudin-7 and claudin-11 can be found in nearly all eutopic and ectopic epithelial cells, the impaired localization of claudin-11 in ectopic endometrium might contribute to the pathogenesis of endometriosis.

    Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.
    Horné F, Dietze R, Berkes E, Oehmke F, Tinneberg HR, Meinhold-Heerlein I, Konrad L.

    05/9/2020
    Study found CLDN11 is a novel target gene of MiR-92a and indicate that its downregulation by extracellular vesicles containing miR-92a also contributes to the pro-angiogenic state of endothelial cells.

    Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells.
    Yamada NO, Heishima K, Akao Y, Senda T., Free PMC Article

    02/1/2020
    our present findings indicate that claudin-11 expression at the BBB, BSCB, and BAB, but not the BCSFB, is downregulated in multiple sclerosis, impairing the functional integrity of these barriers.

    Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis.
    Uchida Y, Sumiya T, Tachikawa M, Yamakawa T, Murata S, Yagi Y, Sato K, Stephan A, Ito K, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T.

    07/6/2019
    Overexpression of snail transcription factor (snail) correlates with increased claudin-11, and both are associated with a worse outcome.

    Snail-induced claudin-11 prompts collective migration for tumour progression.
    Li CF, Chen JY, Ho YH, Hsu WH, Wu LC, Lan HY, Hsu DS, Tai SK, Chang YC, Yang MH.

    04/20/2019
    expression of claudin-11 in cutaneous squamous cell carcinoma (cSCC) cells depended on the activity of p38delta MAPK; knock-down of claudin-11 enhanced cSCC cell invasion

    Expression of claudin-11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ.
    Nissinen L, Siljamäki E, Riihilä P, Piipponen M, Farshchian M, Kivisaari A, Kallajoki M, Raiko L, Peltonen J, Peltonen S, Kähäri VM.

    07/14/2018
    Authors demonstrated that CLDN11 promoter hypermethylation is a frequent event in LSCC, and contributes to metastasis and progression of LSCC.

    The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma.
    Shen Z, Cao B, Lin L, Zhou C, Ye D, Qiu S, Li Q, Cui X., Free PMC Article

    05/5/2018
    The expression of claudin-11, -23 was remarkably downregulated in gastric cancer.

    Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer.
    Lu Y, Jing J, Sun L, Gong Y, Chen M, Wang Z, Sun M, Yuan Y., Free PMC Article

    09/2/2017
    Claudin-11 might represent the essential component of the blood-testis barrier in human.

    Highly Conserved Testicular Localization of Claudin-11 in Normal and Impaired Spermatogenesis.
    Stammler A, Lüftner BU, Kliesch S, Weidner W, Bergmann M, Middendorff R, Konrad L., Free PMC Article

    08/5/2017
    the expression of miR-99b was inversely correlated with CLDN11 levels . These findings suggest that a high level of miR-99b expression is an independent prognostic factor and correlates with poor survival of patients with Hepatocellular carcinoma (HCC)

    miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudin 11 expression and may serve as a prognostic marker.
    Yang J, Liu X, Yuan X, Wang Z.

    05/14/2016
    CLDN11 is an epigenetic biomarker for malignancy in dysplastic nevus and melanoma.

    Promoter CpG island hypermethylation in dysplastic nevus and melanoma: CLDN11 as an epigenetic biomarker for malignancy.
    Gao L, van den Hurk K, Moerkerk PTM, Goeman JJ, Beck S, Gruis NA, van den Oord JJ, Winnepenninckx VJ, van Engeland M, van Doorn R.

    02/21/2015
    these data suggest that cancer cells may induce CLDN11 overexpression and subsequent collective migration of peritumoral CAFs via TGF-beta secretion.

    Collective migration of cancer-associated fibroblasts is enhanced by overexpression of tight junction-associated proteins claudin-11 and occludin.
    Karagiannis GS, Schaeffer DF, Cho CK, Musrap N, Saraon P, Batruch I, Grin A, Mitrovic B, Kirsch R, Riddell RH, Diamandis EP., Free PMC Article

    10/18/2014
    The expression of claudin-11 was up regulated in gastric cancer tissue.

    The distinct expression patterns of claudin-2, -6, and -11 between human gastric neoplasms and adjacent non-neoplastic tissues.
    Lin Z, Zhang X, Liu Z, Liu Q, Wang L, Lu Y, Liu Y, Wang M, Yang M, Jin X, Quan C., Free PMC Article

    10/4/2014
    The spatial organization of claudin-11 and connexin-43 is altered in men with primary seminiferous tubule failure.

    Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls.
    Haverfield JT, Meachem SJ, O'Bryan MK, McLachlan RI, Stanton PG.

    11/30/2013
    disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis.

    Expression pattern of testicular claudin-11 in infertile men.
    Chiba K, Yamaguchi K, Ando M, Miyake H, Fujisawa M.

    01/12/2013
    Treatment with 3-deazaneplanocin A, an inhibitor of H3K27 methyltransferase, attenuated CLDN11 induction by serum stimulation in parallel with sustained miR-1275 expression

    Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells.
    Katsushima K, Shinjo K, Natsume A, Ohka F, Fujii M, Osada H, Sekido Y, Kondo Y., Free PMC Article

    11/17/2012
    claudin-11 may have a role in preventing cancer progression and may serve as a therapeutic target in reducing metastasis

    Claudin-11 decreases the invasiveness of bladder cancer cells.
    Awsare NS, Martin TA, Haynes MD, Matthews PN, Jiang WG.

    08/13/2011
    late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the blood testis barrier in the human testis

    Claudin-11 expression increased in spermatogenic defect in human testes.
    Nah WH, Lee JE, Park HJ, Park NC, Gye MC.

    01/22/2011
    Claudins 11,expression in meningiomas.

    Claudins 1, 11 and twist in meningiomas.
    Soini Y, Rauramaa T, Alafuzoff I, Sandell PJ, Kärjä V.

    11/6/2010
    hypermethylation of CLDN11, leading to downregulated expression, contributes to gastric carcinogenesis by increasing cellular motility and invasiveness

    Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells.
    Agarwal R, Mori Y, Cheng Y, Jin Z, Olaru AV, Hamilton JP, David S, Selaru FM, Yang J, Abraham JM, Montgomery E, Morin PJ, Meltzer SJ., Free PMC Article

    05/3/2010
    Contribution of the tight junction protein CLDN11 to barrier function in endothelial cells is novel and may reflect hemodynamic requirements of the corpus cavernosum.

    Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function.
    Wessells H, Sullivan CJ, Tsubota Y, Engel KL, Kim B, Olson NE, Thorner D, Chitaley K., Free PMC Article

    03/15/2010
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