| Identification of Down-Expressed CRNN Associated with Cancer Progression and Poor Prognosis in Laryngeal Squamous Cell Carcinoma. | Identification of Down-Expressed CRNN Associated with Cancer Progression and Poor Prognosis in Laryngeal Squamous Cell Carcinoma.
Hong F, Wan X, Bai Y. | 04/3/2024 |
| knockdown of CRNN by small interfering RNA suppressed G1/S transition and attenuated the M5-induced proliferation. In addition, CRNN overexpression increased the phosphorylation and activation of phosphoinositide 3-kinase and Akt. Inactivation of the phosphoinositide 3-kinase and Akt pathways using small interfering RNA or selective inhibitors (LY294002 and MK2206) reduced the proliferative effects of CRNN | Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.
Li C, Xiao L, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N, Zheng Y. | 11/2/2019 |
| This study showed a significant correlation between LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of CRNN gene could be considered as a prognostic marker of OSCC. | Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.
Salahshourifar I, Vincent-Chong VK, Chang HY, Ser HL, Ramanathan A, Kallarakkal TG, Rahman ZA, Ismail SM, Prepageran N, Mustafa WM, Abraham MT, Tay KK, Zain RB. | 07/1/2017 |
| The single-nucleotide polymorphisms of CRNN (rs941934) and RPTN (rs3001978, rs28441202) may contribute to Atopic Dermatitis development, but further studies on a larger group of Atopic Dermatitis patients are needed to verify this assumption. | Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.
Trzeciak M, Sakowicz-Burkiewicz M, Wesserling M, Gleń J, Dobaczewska D, Bandurski T, Nowicki R, Pawelczyk T. | 04/1/2017 |
| Loss of CRNN expression correlated with advanced tumor length, greater tumor invasion depth, lymph node metastasis, and poor survival in patients with esophageal squamous cell carcinoma. | Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma.
Hsu PK, Kao HL, Chen HY, Yen CC, Wu YC, Hsu WH, Chou TY. | 06/28/2014 |
| Findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC. | Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.
Chen K, Li Y, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY., Free PMC Article | 02/22/2014 |
| cornulin is an important molecule in normal esophageal pathology and is likely lost during the conversion of normal to neoplastic epithelium | Downregulation of cornulin in esophageal squamous cell carcinoma.
Pawar H, Maharudraiah J, Kashyap MK, Sharma J, Srikanth SM, Choudhary R, Chavan S, Sathe G, Manju HC, Kumar KV, Vijayakumar M, Sirdeshmukh R, Harsha HC, Prasad TS, Pandey A, Kumar RV. | 06/29/2013 |
| Negative regulation of SIRT1 by DBC1 may retard tumorigenesis in breast tissue, so the correlation between SIRT1 and DBC1 is a potential prognostic indicator in breast cancer. | Balance between SIRT1 and DBC1 expression is lost in breast cancer.
Sung JY, Kim R, Kim JE, Lee J., Free PMC Article | 08/16/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma in a Chinese population.
Zhang W, Chen X, Luo A, Lin D, Tan W, Liu Z., Free PMC Article | 08/12/2009 |
| CRNN mRNA expression is decreased in eczematous skin | Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema.
Liedén A, Ekelund E, Kuo IC, Kockum I, Huang CH, Mallbris L, Lee SP, Seng LK, Chin GY, Wahlgren CF, Palmer CN, Björkstén B, Ståhle M, Nordenskjöld M, Bradley M, Chua KY, D'Amato M. | 01/21/2010 |
| Results describe the cloning of porcine SEP53, its homology to the human protein, and its expression in the esophagus and in gastric squamous epithelium. | An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses.
Nelson L, Anderson S, Archibald AL, Rhind S, Lu ZH, Condie A, McIntyre N, Thompson J, Nenutil R, Vojtesek B, Whitelaw CB, Little TJ, Hupp T., Free PMC Article | 01/21/2010 |
| SEP53 may be a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen | Adaptive evolution of a stress response protein.
Little TJ, Nelson L, Hupp T., Free PMC Article | 01/21/2010 |